Solid solution perforator containing drug particle and/or drug-adsorbed particles

A drug and particle technology, applied in the field of solid solution perforators containing drug particles and/or drug adsorption particles, can solve problems such as infection and irritation

Inactive Publication Date: 2010-03-31
THERAJECT INC.
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Unfortunately, silicon needles are not soluble in the skin and can cause considerable irritation and even infection when broken in use

Method used

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  • Solid solution perforator containing drug particle and/or drug-adsorbed particles
  • Solid solution perforator containing drug particle and/or drug-adsorbed particles
  • Solid solution perforator containing drug particle and/or drug-adsorbed particles

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Embodiment Construction

[0045] The practice of the present invention will employ, unless otherwise indicated, conventional methods of chemistry, biochemistry, pharmacology and drug delivery, within the skill of the art. These techniques are explained in detail in ref.

[0046] All publications, patents and patent applications cited herein (whether supra or infra) are hereby incorporated by reference in their entirety.

[0047] It must be noted that, as used in this specification and the appended claims, the singular forms "a", "an" and "the" include plural referents unless clearly stated otherwise. Thus, for example, reference to "a protein" includes mixtures of two or more polypeptides, and the like.

[0048] figure 1 is a cross-sectional view of the upper layers of skin 11 , including stratum corneum 13 , epidermis or epidermis 15 and dermis or dermis 17 . The outermost layer of the skin, the stratum corneum 13, is a layer of dead cells, typically 10-20 micrometers ([mu]m) thick. The stratum co...

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Abstract

A solid drug solution perforator containing drug particles (402) and / or drug-adsorbed or loaded particles with an associated drug reservoir (SSPP system) (40Q) are provided for delivering therapeutic,prophylactic and / or cosmetic compounds, diagnostics, and for nutrient delivery and drug targeting. For drug delivery, the SSPP system includes an active drug ingredient (402) in particulate form or drug adsorbed on the particle surface in a matrix material (411) that dissolves upon contact with a patient's body (11). In a preferred method of transdermal drug delivery, an SSPP system containing adrug-adsorbed microparticle (402) penetrates into the epidermis (15) or dermis (17), and the drug (402) is released from the (dissolving) SSPP system perforator (400) and desorbed from the particles.An additional drug is optionally delivered from a patch reservoir (601) through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSPP and associated reservoir are also provided. An SSPP system can be fabricated with variety of shapes and dimensions.

Description

[0001] Cross References to Related Applications [0002] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application Serial No. 60 / 714,469, filed September 6, 2005, which is incorporated herein by reference in its entirety. technical field [0003] The present invention relates to the controlled delivery of one or more drugs into a patient, and the diagnosis of fluids in a patient. Background of the invention [0004] Many new biopharmaceutical drugs, including proteins, peptides, nucleotides and DNA components and genes, have been developed to treat diseases better and more effectively. Now, especially due to recent advances in molecular biology and biotechnology, therapeutic proteins from biotechnology are available, such as recombinant human insulin, growth hormone, and erythropoietin, to name a few. However, a major limitation in the use of these new drugs is the lack of effective drug delivery systems; the drug must be transported across on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/30A61L15/16
CPCA61M2037/0046A61K2039/55555A61M37/0015A61K2039/54A61K9/0021A61M2037/0053A61M2037/0023A61K9/00A61K38/00A61K39/00
Inventor 权圣润
Owner THERAJECT INC.
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