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Method for obtaining alimentary absorption characteristic of medicament

A technology of absorption characteristics and digestive tract, which is applied in the field of obtaining the absorption characteristics of drugs in the digestive tract, can solve the problems of unreliable research data, poor repeatability, and unreliable location, and achieve high reliability, easy operation, and reliability of data provided Effect

Inactive Publication Date: 2007-05-23
CHONGQING UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] In recent years, with the development of biomaterial technology, using enteric-coated capsules that can disintegrate in specific parts of the digestive tract to achieve fixed-point release of drugs in the digestive tract is one of the important methods to obtain the absorption characteristics of drugs in the digestive tract, but , the existing problem is that the current enteric-coated capsule technology generally realizes the disintegration of the capsule material according to the change of the pH value of the intestinal tract or the change of microorganisms. Due to the great individual differences of the human body or experimental animals, the disintegration of the capsule Unreliable location, poor repeatability, unreliable research data obtained

Method used

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  • Method for obtaining alimentary absorption characteristic of medicament
  • Method for obtaining alimentary absorption characteristic of medicament

Examples

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Embodiment 1

[0021] The purpose of this example is to obtain the absorption characteristics of the drug to be studied in the human colon. The drug to be studied is aminophylline, and the chemical name of aminophylline is 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-diketone-1,2-ethylenediamine salt dihydrate substance, the molecular formula is C 2 h 8 N 2 (C 7 h 8 N 4 o 2 ) 2 2H 2 O, with a molecular weight of 456.46, is mainly used clinically for bronchial asthma, wheezing bronchitis, obstructive emphysema, etc. to relieve wheezing symptoms, and can also be used for asthma caused by cardiogenic pulmonary edema. The test subjects were 8 male healthy volunteers, the dosage form was powder dosage form, and the planned drug release location was the transverse colon.

[0022] The specific method steps are:

[0023] 1. The dosage form preparation of test medicine, takes by weighing 8 parts of aminophylline powders, every part of 150mg,

[0024] 2. The encapsulation of the test drug, select...

Embodiment 2

[0033] The purpose of this example is to obtain the drug absorption characteristics of the drug to be studied in the digestive tract of volunteers. The drug to be studied is carbamazepine, chemical name: 5H-dibenzo[b,f]azepine-5-carboxamide, molecular formula: C15H12N20 molecular weight: 236.27. The test subjects were selected as 8 male healthy volunteers, and the dosage form of the test drug was an aqueous solution.

[0034] The specific implementation steps of this embodiment include three sets of steps as described in Example 1, each set of steps is for the fixed-point release of drugs in a specific part of the digestive tract, namely the stomach, duodenum, and colon. As shown in Table 1. After a set of test procedures is completed, after a certain drug elimination period (generally 7 days), the next set of tests is carried out.

[0035] The specific method steps of each group of experiments are as follows:

[0036] 1. The preparation of the dosage form of test medicine,...

specific Embodiment 3

[0047] The purpose of this example is to obtain the absorption characteristics of the drug to be studied in the colon of Beagle dogs. The drug to be studied is matrine. Matrine is an alkaloid extracted from the roots of Sophora flavescens and Sophora flavescens. Its molecular formula is C15H24N2O and its molecular weight is 248.36. It is mainly used clinically to treat cancer, Viral hepatitis, leukopenia, bronchial asthma and asthmatic bronchitis, etc.

[0048] In the specific implementation steps of this embodiment, two groups of steps as described in Example 1 are included, each step adopts a dosage form of the medicine, and the dosage form is an aqueous solution dosage form or a powder dosage form, and each group of steps requires 8 ratios. Greyhound. Each group of steps performs fixed-point drug release of a drug dosage form, and the drug release site is the colon, as shown in Table 2. After a set of test procedures is completed, after a certain drug elimination period (...

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Abstract

The invention relates to a method for obtaining the drug enteron adsorption property, wherein it comprises that: (1), preparing the agent of drug; (2), packing said agent into storage chamber of remote-control electric capsule; (3), test animal or people takes said capsule; (4), tracking the position of capsule in the body; (5), remote-control releasing drug; (6), collecting sample of body fluid or blood and preparing; (7), analyzing blood drug density; (8), extracting the drug metabolism kinetics parameters. The inventive method can obtain the drug adsorption property in enteron accurately, with high reliability.

Description

Technical field: [0001] The invention relates to a method for obtaining the absorption characteristics of the digestive tract of drugs, in particular to a method for non-invasively obtaining the absorption characteristics of the drugs in various parts of the digestive tract. Background technique: [0002] The development of new molecular entities (New Molecular Entities, NMEs) or new chemical entities (New Chemical Entities, NCEs) is the focus of new drug development. The advent of technologies such as proteomics, genomics, combinatorial chemistry, and high-throughput screening has led to an unprecedented increase in the number of drug candidates. These NMEs tend to have more complex chemical structures, and more importantly, these NMEs often do not have good biopharmaceutical properties, for example, 55% poor water solubility, and many drugs have poor permeability. According to statistics, currently less than 5% of the compounds can pass the preliminary pharmacodynamic scr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00G01N33/483
Inventor 刘洪英皮喜田郑小林侯文生彭承琳
Owner CHONGQING UNIV
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