Azoxystrobin suspension concentrate with particle sizes of less than 100nm and preparation method of azoxystrobin suspension concentrate

A water suspension, azoxystrobin technology, applied in botany equipment and methods, fungicides, chemicals for biological control, etc., can solve Oswald ripening, wide particle size distribution, stratification or agglomeration, etc. question

Active Publication Date: 2017-12-01
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the following problems still exist in various suspending agents at present: 1) Large particle size, easy to float or settle, resulting in stratification or agglomerati

Method used

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  • Azoxystrobin suspension concentrate with particle sizes of less than 100nm and preparation method of azoxystrobin suspension concentrate
  • Azoxystrobin suspension concentrate with particle sizes of less than 100nm and preparation method of azoxystrobin suspension concentrate
  • Azoxystrobin suspension concentrate with particle sizes of less than 100nm and preparation method of azoxystrobin suspension concentrate

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0028] Example 1: Preparation of 30mL azoxystrobin nano-water suspension (containing 3mg azoxystrobin technical, 3-30 μL Tween 80 and 3.0mL ethanol):

[0029] Dissolve 3 μL Tween 80 and 3 mg azoxystrobin original drug in 3.0 mL ethanol to form an organic phase.

[0030] Take 3 mL of water as the aqueous phase.

[0031] The aqueous phase and the organic phase were respectively injected into the two micro-cavities of the mixer, so that the two micro-cavities were jetted against each other, and the mixing took about 5 seconds in total. Collect the mixed solution with 24 mL of water to obtain 30 mL of azoxystrobin nanosuspension.

[0032] Using the same method, 10, 20, and 30 μL of Tween 80 were used to repeat the above experiments to prepare nano-suspensions with different Tween-80 contents, and the size of the suspensions was measured by dynamic light scattering, and the stability over time was tracked.

[0033] like figure 1 As shown, when the dosage of Tween 80 is 10-30 μL ...

example 2

[0034] Example 2: Preparation of 30mL azoxystrobin nano-scale aqueous suspension (containing 3mg azoxystrobin technical, 0.6-3mg PLGA-PEG and 3.0 mL acetone):

[0035] Take 0.6 mg amphiphilic copolymer PLGA-PEG and 3 mg azoxystrobin original drug dissolved in 3.0 mL acetone to form an organic phase.

[0036] Take 3 mL of water as the aqueous phase.

[0037] The aqueous phase and the organic phase are respectively injected into the two micro-chambers of the mixer, so that the two micro-chambers are jetted against each other, and the mixing takes about 5 seconds in total. Collect with a container containing 24ml of water to obtain 30mL of azoxystrobin suspension.

[0038] And with the same method, take 3mg PLGA-PEG to repeat the above experiment, and make 30mL corresponding azoxystrobin nanosuspension. The suspending agent was measured by the dynamic light scattering method, and the initial average diameter was 83nm, and the PDI was 0.29. And track the time stability (such as...

example 3

[0040] Example 3: Comparison of the preparation by drop stirring method and jet hedging mixing method (30mL nano-scale aqueous suspension contains 3mg azoxystrobin original drug, 3mg PLGA-PEG and 3.0mL propanol):

[0041] Dissolve 3 mg of PLGA-PEG and 3 mg of azoxystrobin in 3.0 mL of propanol to form an organic phase.

[0042] Take 3 mL of water as the aqueous phase.

[0043]The aqueous phase and the organic phase were respectively injected into the two micro-cavities of the mixer, so that the two micro-cavities were jetted against each other, and the mixing took about 5 seconds in total. Collect with a container containing 24ml of water to obtain 30mL of azoxystrobin suspension.

[0044] With the same ratio, configure the aqueous phase and the organic phase, slowly add 27mL of water to 3mL of the organic phase dropwise, and at a rotation speed of 900rpm, drop it within 2 hours to obtain 30mL of azoxystrobin suspension.

[0045] Suspensions were tested for temporal stabilit...

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Abstract

The invention discloses azoxystrobin suspension concentrate with particle sizes of less than 100nm and a preparation method of the azoxystrobin suspension concentrate and belongs to the technical field of production of nano-pesticides. The method comprises the steps of dissolving azoxystrobin into a water-soluble organic solvent as an organic phase, adopting water as a water phase and adding a surfactant to at least one phase of water phase or organic phase; and mixing the water phase with turbulent flow of the organic phase through a fast jet hedging blending method, carrying out collection by using water or surfactant-containing water to prepare the azoxystrobin suspension concentrate. The suspension concentrate prepared by adopting the method is stable in particle size and narrow in dispersion, is smaller than 100nm, is conducive to drug adsorption on the blade surface and is capable of withstanding blowing and rain washing, osmosis and conduction to a blade can be strengthened, and the azoxystrobin suspension concentrate has the characteristics of being friendly to environment, prone to environmental degradation and high in medicinal effect.

Description

technical field [0001] The invention belongs to the technical field of production of nanopesticides, in particular to the technical field of production of azoxystrobin-containing pesticide suspensions. Background technique [0002] In the field of pesticides, nano-pesticides are often defined as particles with a particle size of less than 1 micron from a broad perspective of application. Due to the unique small size and large surface area effect of drug nanoparticles, they exhibit excellent high-efficiency properties. [0003] Common dosage forms of pesticides include: powder, granule, smoke, water, oil, suspension, emulsion, etc. Generally, powders, granules, and smoke agents are difficult to be absorbed and effective, and are easy to cause dust and cause great pollution to the environment. At the same time, many pesticide technical materials are difficult to dissolve in water, so it is difficult to make water formulations. However, it needs to use a large amount of orga...

Claims

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Application Information

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IPC IPC(8): A01N25/04A01N43/54A01P3/00
CPCA01N25/04A01N43/54
Inventor 朱正曦邵川华郭彦麟
Owner YANGZHOU UNIV
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