Method for removing ginkgolic acid from ginkgo leaf extract by extraction method

A technology of Ginkgo biloba leaves and extracts, which is applied in the field of deacidification of ginkgolic acid, can solve the problems of organic residues of resin, complicated operation and the like, and achieves the effects of simple operation, cheap raw materials and good deacidification effect.

Inactive Publication Date: 2004-01-28
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The traditional deacidification process uses the resin method, but the method involves the problem of organic residues in the resin, and mass production requires special equipment, repeated washing, etc., and the operation is cumbersome

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1: Get an appropriate amount of Ginkgo biloba crude extract, add 10 times the amount of absolute ethanol or methanol, stir and dissolve overnight and then filter, then dissolve it with 5 times the amount of 50% ethanol after drying, add an equivalent amount of petroleum ether, Extract 3-8 times, recover the ethanol layer, concentrate under reduced pressure, and dry in vacuum to obtain the ginkgo leaf extract of deginkgolic acid.

Embodiment 2

[0009] Embodiment 2: Take an appropriate amount of ginkgo biloba crude extract, add 10 times the amount of absolute ethanol or methanol and stir to dissolve, leave it overnight, filter, add 5 times the amount of absolute ethanol or methanol to the residue, stir and dissolve, filter, and combine the filtrates, Concentrate and dry under reduced pressure, then dissolve with 5 times the amount of 50% acetone, add the same amount of n-hexane or cyclohexane to extract for 3-8 times, recover the acetone layer, concentrate under reduced pressure, and dry in vacuum to obtain Ginkgo biloba leaves Extract.

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PUM

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Abstract

The present invention discloses a method for removing ginkgolic acid from ginkgo leaf extract by orgnaic solvent extraction process, and said process mainly includes: extracting and drying. In which the refining procedure includes: adding methyl alcohol or ethyl alcohol to pulverized ginkgo leaf extract, stirring, dissolving, standing still, filtering, reduced pressure concentrating and drying; and its extracting procedure includes: stirring the pulverzed ginkgo leaf extract with ethyl alcohol or acetone, dissolving and placing said material into extract, adding paraffins material, uniformly mixing them, standing still and demixing, removing upper layer, repeatedly operating lower layer for several times, drying.

Description

technical field [0001] The invention relates to a method for removing ginkgolic acid from ginkgo leaf extract by using organic solvent extraction. Background technique [0002] The pharmacologically active ingredients in Ginkgo biloba extract are mainly total flavonol glycosides and ginkgo terpene lactones. They have definite curative effect on cardiovascular and cerebrovascular diseases, but the ginkgo biloba extract currently available on the market contains a large amount of ginkgolic acid mixture, which has strong sensitization to the human body and can cause contact dermatitis and the like. Therefore, controlling the content of ginkgolic acid in the finished product is essential to ensure the safety of its preparation and improve the quality of the product. The traditional deacidification process uses the resin method, but the method involves the problem of organic residues in the resin, and mass production requires special equipment, repeated washing, etc., and the op...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02C07B63/00
Inventor 黄淑萍王东刘承伟欧亚华戴军平王丽瑶
Owner YANGTZE RIVER PHARM GRP CO LTD
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