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Prepn of polygelatine peptide injection

A polygelatin peptide and preparation process technology, which is applied to medical preparations containing active ingredients, blood diseases, extracellular fluid diseases, etc., can solve the problems that the production process of Haimain has not been disclosed, and achieve product quality control and production qualification high rate effect

Inactive Publication Date: 2003-01-01
武汉华龙生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production process of Haimainsu has not been made public

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Production of Gelatin Injection according to the requirements of the technical scheme:

[0023] 1. Sol: The temperature of the hot water for injection is 73-80°C, and the bovine bone, pork bone or other gelatin is put in

[0024] The weight is 3-10% of the weight of water for injection;

[0025] 2. Thermal degradation: adjust the pH value of beef bone, pork bone or other gelatin aqueous solution between 5.0 and 6.0,

[0026] Raise the temperature to 110°C~125°C, maintain 110°C~125°C for 2~4 hours, every 10~20 minutes

[0027] Measure the relative viscosity, and when the relative viscosity reaches 2.0-2.5, stop heating and cool quickly to

[0028] 30~37℃;

[0029] 3. Cross-linking: adjust the pH value of the degradation solution to 6.5-7.5, maintain the temperature at 25-35°C for 1-3 hours, add

[0030] Add a cross-linking agent with a gelatin protein content of 0.7-1.2%. The cross-linking agent can be selected from succinic anhydride or ethylene glycol

[0031] Ald...

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PUM

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Abstract

The polygelatin peptide injection is prepared with gelatin of ox bone, pig bone, etc. and through dissolving, hot degradation in controlled condition, cross-linking with non-toxic cross-linking agent, mixing with electrolyte, adsorption, clarification and stepped filtering to separate cross-linked spherical molecule. During the preparation, the molecular weight of the cross-linked matter is well controlled.

Description

technical field [0001] The invention belongs to a polygeline peptide production process, in particular to a process for producing polygeline peptide injection with bovine bone, pig bone or other gelatin. Background technique [0002] At present, a small amount of Haimain made by hydrolysis of bovine bone gelatin is imported domestically. It is widely used in domestic hospitals to supplement blood volume in various operations, traumatic blood loss, toxic shock, etc., and has replaced plasma. At present, mad cow disease is spreading in Western Europe, and countries have strictly controlled the import of cattle and their products. The production process of Haimainsu has not been made public. Oxidized polygelatin injection was developed in my country in the 1980s. However, due to the gap between the quality of the product at that time and that of imported products, it should be improved and confirmed especially in terms of molecular weight determinat...

Claims

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Application Information

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IPC IPC(8): A61K38/02A61P7/06
Inventor 董道维
Owner 武汉华龙生物制药有限公司
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