The invention provides a preparation method of 1, 4-butanediol diglycidyl ether, and relates to the technical field of organic synthesis. According to the invention, an efficient Lewis acid catalyst is adopted in an etherification reaction stage of 1, 4-butanediol and epoxy chloropropane, then a catalyst is added through a main reaction, an aqueous alkali solution is dropwise added in a segmented mode, and negative-pressure closed-loop reflux dehydration is conducted in a segmented mode, so that the water content of a reaction system is reduced, the reaction forward process is promoted, the prepared 1, 4-butanediol diglycidyl ether product is low in hydrolytic chlorine and high in yield, the residual alkali amount and TOC of wastewater are reduced, the problems of too high residual alkali amount and high organic matter content in saline water are solved, and industrial clean production of the 1, 4-butanediol diglycidyl ether is realized; and the preparation method has the advantages of stable process, continuous production operation, avoidance of tedious solid caustic soda feeding, high safety, low raw material consumption and low production cost.