Application of exenatide to preparation of medicines for treating ocular ischemia diseases and improving ocular blood circulation in eye drip way

A technology of exenatide and drugs, which is applied in the field of medicine to achieve the effect of reducing eye blood supply damage, reducing fear, and high local concentration
CN111166870APending Publication Date: 2020-05-19EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
Publication Date
2020-05-19

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Abstract

The invention relates to the technical field of medicines, in particular to application of exenatide to preparation of medicines for treating ocular ischemia diseases and improving ocular blood circulation in an eye drip way. The exenatide can be used for treating the ocular ischemia diseases such as onset of acute glaucoma and improving the ocular blood circulation . According to the applicationdisclosed by the invention, through building an acute ischemia reperfusion model and simulating damage of the onset of the acute glaucoma, findings prove that an eye drop preparation of Exendin-4 canimprove a retinal vascular endothelial function, dilating retinal capillary and recovering fundus blood circulation, so that the damage to the fundus blood supply caused by the ocular ischemia diseases such as acute glaucoma can be effectively alleviated, and simultaneously, the findings prove that a new medicine dosage form (eye drop preparation) can achieve an effective local action under the premise of avoiding systemic action. The exenatide disclosed by the invention can be used for treating deficiency of the fundus blood supply such as the acute glaucoma, retinopathy of prematurity and retinal vascular occlusion diseases, and thus, the visual function is saved.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to the application of exenatide in the preparation of eye drops for treating ocular ischemic diseases and improving ocular blood circulation. Background technique

[0002] The fundus retina has a great demand for blood oxygen supply. Efficient supply ensures the normal operation of fundus optic nerve metabolism, and the reduction of retinal blood flow often leads to damage of optic nerve cells. [1] . Ischemia-reperfusion can exist in a variety of intraocular disease states, including acute glaucoma attack, retinopathy of prematurity, retinal vascular occlusive disease, etc. [2] . Among them, in patients with acute angle-closure glaucoma attacks, their intraocular pressure often rises sharply, even reaching above 60mmHg. At this time, the fundus blood flow is significantly reduced. . However, when the intraocular pressure is reduced and the blood supply is restored by means of p...

Claims

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