158 results about "Fundus (eye)" patented technology

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

A system for diagnostically evaluating the health of tissue within the fundus of an eye includes a f s laser source, an adaptive optical assembly, an imaging unit, and a computer. The adaptive optical assembly focuses a laser beam to a focal point in the fundus of the eye, and scans the fundus tissue according to a predetermined scanning pattern. Illumination of anisotropic tissue within the fundus, such as the photoreceptors and the Henle-fiber layer, induces a Second Harmonic Generation (SHG) response. Red photons, with a wavelength (λ) of about 880 nm, are converted to blue photons, with a wavelength of λ/2, through the process of photon conversion. An imaging unit senses the blue photon return light, and uses the return light to generate an image of the fundus. The computer processes the image, and compares it to a template of healthy tissue to evaluate the health of the imaged tissue.

Short sight, visual fatigue and ischemic ophthalmopathy belong to the cataract diseases of oculopathy and are mostly caused by emotion problems or body fluid loss, blood shortage, weak kidney and liver which lead to the disorder of entrails, no moistening of eyes, blood stasis, etc., thus causing the loss of sight and even other neopathy. The treatment principle is that the traditional Chinese medicine components which can strengthen the liver and the kidney, supplement blood and body fluid, activate blood circulation to dissipate blood stasis, invigorate the spleen, and be beneficial for moistening are selected; the medicinal materials are extracted (63 percent of effective components, 30 percent of film-forming agent and 7 percent of plasticizer) and blended evenly to make the Chinese medicinal plaster with the thickness of 0.08 to 0.12cm and the plaster is then dried at the normal temperature (the temperature is controlled below 40 DEG C), cut and packaged into a finished product. The medicine can be applied to the skin around the eye and be finally acted on the target area in the ocular fundus after being absorbed by capillary vessels of the skin into the blood circulation of the eye.

The invention discloses a human eye aberration measuring system based on phase diversity, which comprises an optical illuminating system, a pupil aligning system, an optical staring system and an optical imaging system. The optical illuminating system is mainly an optical system which illuminates the fundus oculi of a human eye by the aid of infrared during detection, the pupil aligning system is a system for aligning the human eye with an optical axis of the optical illuminating system and an optical axis of the optical imaging system before detection, the optical staring system is mainly an optical system for fixing the position of the eyeball of the human eye during detection, and the optical imaging system is mainly a system for realizing observation imaging for the area of the fundus oculi illuminated by the illuminating system. The human eye aberration measuring system overcomes shortcomings that in the prior art, objective aberration measurement time is long, individual aberration correction cannot be guided, measurement accuracy is low, a measurement range is small and the like.

Methods and systems for imaging the fundus of the eye are disclosed, in which the fundus is illuminated through a mask which blocks light from reaching one or more masked regions within a peripheral area surrounding a target area of interest, such as the macular region. An image is obtained of both the target area and the peripheral area. A scattered light value is derived from the image intensity within the masked regions, and this is used to compensate and adjust the measured intensity of light within the target area. When employed in the measurement of macular pigment optical degeneration, an improved measurement is obtained in which the specific image(s) used for measurement have a specifically calculated correction factor applied to compensate for light scatter, rather than relying on population-based average scattering values.

The invention provides an automatic alignment and focusing fundus or anterior segment imaging system. The system is placed on an X-Y-Z three-axis electric platform. The system comprises an illumination unit, an imaging unit, a guide alignment unit, an optical coherence tomography (OCT) unit and an eyepiece (201). The imaging unit comprises an imaging light path and a light path conversion device.When the system performs anterior segment imaging, the light path conversion device is moved into the imaging unit; and when the system performs fundus imaging, the light path conversion device is removed from the imaging unit. According to the invention, anterior alignment is realized through an anterior alignment unit, fundus alignment is realized through the guide alignment unit, or anterior alignment and fundus alignment are realized directly through the guide alignment unit, so that anterior segment and fundus imaging is realized, a professional technician does not need to be equipped inthe whole operation process, and the whole operation process is autonomously completed by the imaging system. The imaging system is awakened from a dormant state through a signal of a pressure sensorI and is in a dormant state in a non-working period, so that the energy consumption of the system is reduced. Therefore, unattended eye imaging is realized.

The invention discloses a method and glasses for lowering the diopter of eyes. The method is characterized in that a user wears glasses for far vision conventionally at ordinary times but wears glasses for near vision when writing, reading and doing other work requiring near vision, and if eye discomfort occurs during wearing, the user can replace lenses of the glasses for far vision and the glasses for near vision till feeling comfortable. The pair of glasses for far vision comprises a glasses frame, a pair of lens groups is arranged on the glasses frame and comprises prism lenses and optical lenses, the prism lenses are arranged on the side close to the eyes of the user, at least one of the rear surface and the front surface of each optical lens comprises a toroidal surface optical area, and the fundus direction of each prism lens is adjustable. The pair of glasses for near vision comprises a glasses frame, a pair of lens groups is arranged on the glasses frame and comprises prism lenses, additional lenses for near vision and optical lenses, the prism lenses are arranged on the side close to the eyes of the user, and the additional lenses for near vision are arranged between the prism lenses and the optical lenses. The method and the glasses have the beneficial effect that the diopter can be lowered after the user wears the glasses.

The invention discloses a cataract OCT image restoration method and system based on machine learning. The cataract OCT image restoration method introduces an optical information processing technology, changes the frequency spectrum of an object through an optical spatial filter, carries out the amplitude, phase or composite filtering of an inputted image, and carries out the fuzzy processing of the image, thus achieving the simulation of a cataract OCT fuzzy image; then the neutral density attenuation sheet is added to an OCT scanner lens to scan healthy eyeballs, a fundus OCT blurred image is obtained to simulate a cataract image, then an OCT clear image of the same person without the attenuation sheet is scanned, and the cataract retina OCT blurred image is restored into a clear image. The ten layers of retina structures can be clearly seen from the restored image, and the number of network models is reduced, so that the workload and the total training time are reduced, and the technology of restoring the blurred image to be clear is realized only by using the Pix2pix model.

The invention relates to an operation intelligent decision-making system suitable for high myopia cataract and an establishment method thereof. The establishment method comprises the following steps:constructing a deep learning model being composed of an evaluation network and a decision network, configuring evaluation network to comprise a LOCSIII grading deep learning model, an Elasticity kernel hardness grading deep learning model and a fundus judgment model, and configuring the decision network to combine the cataract degree and fundus grading with patient basic information, eyesight, intraocular pressure, an A-ultrasonic/IOLmaster report, corneal endothelium counting, corneal astigmatism, a B-ultrasonic report and other information, map the information to a high-dimensional space through a kernel function, and then establish a linear regression model; constructing a training set; and carrying out training learning and parameter adjustment on the model by using a training set. Thesystem comprises a storage device, an evaluation module, a decision module and a test evaluation adjustment module. The method can quickly and accurately identify the cataract degree and fundus conditions of a high myopia cataract patient, provide comprehensive operation decisions for doctors, and improve the prevention and treatment homogeneity.

The invention discloses application of transthyretin in transferring fusion protein into eyes, belonging to the technical field of protein engineering. The invention provides a method for allowing foreign protein to pass through eye barriers and to be conveyed into eyes through fusion expression of transthyretin as shown in SEQ ID NO.1 and the foreign protein. The results of animal experiments prove that as the fusion protein prepared in the invention is used for eye drop treatment on rats and rabbits, foreign protein can be rapidly and effectively conveyed to fundus. The transthyretin used inthe method is derived from a human body, has good biocompatibility and safety in the human body, and has important application prospects when used as a substitute of injection drugs in the field of medicine.

The invention discloses a vision rehabilitation instrument. The vision rehabilitation instrument comprises a shell, a light shield, a sight hole opening and closing device, an eye massage device, a circuit control system, an eyepiece, objective lenses, a lens cone, a loudspeaker, an eyeball movement device and a head fixing band, the sight hole opening and closing device is located in the shell, the eye massage device is arranged on the back of the shell in a sleeving mode, the eyepiece, the objective lenses and the lens cone are located on the same axis, the head fixing band is connected to the two sides of the rear portion of the shell, and the circuit control system controls the sight hole opening and closing device, the eye massage device and the eyeball movement device. The vision rehabilitation instrument is reasonable in structure, accurate in acupoint pressing and stable in pressing force, eye muscles can be exercised by training eyeball movement, fundus visual cells can be stimulated by irradiating fundus with red LED light, growth and development of the visual cells are promoted, shading training and bright and dark training as well as near-looking and distant-looking training are both considered, the adjusting capacity of eyes can be exercised, in the whole training process, the instrument does not make contact with eyes, the eyes cannot be hurt, and the eyesight improving effect is obvious.

The invention relates to the field of artificial intelligence, and provides a method, a device and equipment for screening an abnormity of a fundus macular area and a storage medium, and the method comprises the steps: receiving an adjustment instruction inputted by a user; scanning a macular area of the eyes of the testee through a single-line scanning mode of the optical coherence tomography scanner to obtain a macular area image and a macular area thickness of the testee; inputting the macular area image into a convolutional neural network, and performing convolution operation on the macular area image to obtain a convolution feature matrix of the macular area image; polling the convolutional feature matrix through a pooling layer of the convolutional neural network to obtain multiple groups of local feature sets; and inputting the thickness category into the convolutional neural network, wherein the convolutional neural network performs weighted summation on the macular region setand the thickness category through the weight of neurons. Automatic screening of macular area anomalies is achieved, the screening efficiency of macular area anomalies is improved, the labor cost is reduced, and no damage is caused to eyes in the screening process.

The embodiment of the invention discloses a refraction detection method, a device, computer equipment and a storage medium. The method comprises the steps of acquiring the electronic medical record data of a to-be-tested person, wherein the electronic medical record data comprise the eye axis length and the average corneal refractive power; and predicting the spherical lens degree and the equivalent spherical lens degree according to the electronic medical record data. According to the technical scheme provided by the embodiment of the invention, by collecting the parameters such as the eye axis length and the average corneal refractive power of the to-be-detected person and automatically predicting the spherical lens power and the equivalent spherical lens power of the to-be-detected person, the eye data of the myopia patient can be accurately detected without being influenced by fundus lesions or crystal opacity and the like, and the detection accuracy is improved. Meanwhile, the problem that the paralysis process of ciliary muscles causes side effects and sequelae to the eyes of juveniles is avoided.

An eye surgery surgical system includes a visualization device for visualizing the position of at least one trocar point for a trocar on the sclera of a patient's eye. The trocar serves to introduce a surgical instrument configured for surgical interventions on the fundus of the patient's eye into the patient's eye. The eye surgery surgical system also includes a computer unit which is configured to provide the position of the at least one trocar point to the visualization device. Here, the computer unit contains a trocar point computation routine configured to calculate the position of the at least one trocar point from the location of at least one surgical site in a model of the patient's eye and from geometric data relating to at least one surgical instrument introducible into the patient's eye through the trocar.

The invention provides an automatic screening method for diabetic macular edema based on transfer learning, which comprises the following steps: marking whether diabetic macular edema exists through an optical coherence tomography image and fundus color photograph; extracting eye features of a patient by using the trained deep residual neural artificial intelligence model, classifying whether diabetic macular edema exists according to the eye features, and performing polarity adjustment on the deep residual neural artificial intelligence model by using fundus color photograph data set trainingthrough a transfer learning technology; and obtaining a final intelligent screening model of diabetic macular edema based on fundus color photograph. The optical coherence tomography image and the fundus color photograph are used for identifying and classifying patients suffering from diabetic macular edema or not through the fundus color photograph-based intelligent screening model for diabeticmacular edema, so that the screening accuracy and the working efficiency of diabetic macular edema high-risk groups can be improved, and the expenditure of disease diagnosis and treatment of the patients is also reduced; therefore, more patients can be diagnosed and treated in time.

The invention relates to a composition for protecting eyesight. The composition can be used for protecting eyesight and adjuvant therapy of fundus diseases. The composition is composed of chromium, selenium, docosahexaenoic acid, zinc, xanthophyll and carotene. The composition comprises the following components by mass, 25*10 <-3>-35*10 <-3 > parts of chromium, 40*10<-3 >-60*10 <-3> parts of selenium, 250-350 parts of docosahexaenoic acid (DHA), 20-50 parts of zinc, 8-20 parts of xanthophyll and 3-5 parts of carotene. The composition can be applied to preparation of a medicine and a health care product for preventing and treating myopia, crystalline lens and retinopathy, improving eyesight, relieving asthenopia or tonifying and strengthening brain, which has the function of protecting eyesight by protecting visual cells, can prevent asthenopia and myopia and treat crystalline lens and retinopathy, has the effects of tonifying and strengthening brain, and is a health care product for pregnant women. The product is of great significance to eye and brain health care and maintenance, stabilization and recovery of lens and retina functions.

The invention relates to the technical field of fundus optical coherence tomography imaging, in particular to a head-mounted OCT probe. The probe comprises a head-mounted shell which comprises a testposition corresponding to the eyes of a tested user; an imaging shell provided with an imaging light path corresponding to the test position; and an adjusting assembly used for movably installing theimaging shell in a wearable shell so that the relative positions of the imaging light path and the test position can be adjusted. According to the technical scheme, the imaging light path in the imaging shell is combined with the head-mounted shell; therefore, a light path system and the tested user can be kept in a relatively static state and move along with shaking of the head of the tested user, and the problems that focusing is difficult, the images are difficult to obtain, motion artifacts exist and the like due to the fact that the head of the tested user shakes continuously in a conventional OCT device or a handheld OCT device are solved.

The invention discloses a fundus hard exudate segmentation method based on deep learning, which is characterized in that a double attention module is added on the basis of a traditional Unet model, so that important lesion areas can be concerned; more multi-scale fusion is added, and more feature and semantic information is extracted; finally, a pyramid type fusion mode is used, so that the improved model can effectively improve the detection capability on hard exudate; the invention provides a loss function based on Dice Loss improvement for the class imbalance problem of fundus hard exudate, and the loss function can improve the recall rate of target segmentation and the weight of error segmentation. The loss function is applied to the improved Unet model, so that the segmentation effect can be improved.

The invention relates to a preparation method and application of a nano eye medicine. By construction of a novel nitrogen-doped polypeptide modified graphene nano medicine with excellent catalytic activity, excessive active oxygen in retinal cells is eliminated, the oxidative stress state of the cells is relieved, and related fundus lesions are intervened in the early stage. Nitrogen-containing polypeptide molecules and graphite powder are blended, ball-milled and modified to prepare a nitrogen-doped polypeptide modified graphene nano system. Cell experiments and animal experiments prove thatthe prepared nano system has excellent scavenging capacity on excessive active oxygen in a cell model and an animal model with blue light injury, and reveals feasibility of intervening disease coursedevelopment of the novel nano system in the early stage of fundus lesion. A new thought is provided for treatment of oxidative stress injury fundus diseases.

The invention discloses a near-infrared fundus therapeutic instrument, and relates to the technical field of medical instruments for eye diseases. The near-infrared fundus therapeutic instrument comprises a head-mounted main body and a controller, wherein the head-mounted main body is provided with a near-infrared light source electrically connected with the controller, the near-infrared light source is used for irradiating the fundus of a tested user, the near-infrared light source has a plurality of preset light emitting powers, and the controller is used for controlling the near-infrared light source to select the corresponding preset light emitting power so as to adapt to the fundus disease condition of the tested user. The near-infrared fundus therapeutic instrument can conveniently and effectively assist in treating fundus diseases such as central serous retinitis, senile macular degeneration, and the like.