6results about How to "Verify security" patented technology

The present application relates to the technical field of biological medicine, and discloses inhalable aptamer modified molybdenum disulfide nanoflower compound and application thereof.The compound comprises a molybdenum disulfide nanoflower core, a dendritic polylysine modification layer attached to the surface of the molybdenum disulfide nanoflower, doxorubicin loaded on the molybdenum disulfide nanoflower and / or the dendritic polylysine modification layer, and AS1411 aptamer combined on the outer surface of the dendritic polylysine modification layer by electrostatic assembly.The compound can be delivered to a lung lesion by atomization inhalation or aerosol inhalation, and undergoes responsive structural change under the action of hydrogen peroxide in a tumor microenvironment, generates active oxygen, and promotes the release of doxorubicin, so as to realize the synergistic antitumor effect of chemotherapy and chemical dynamic therapy.The compound has good colloidal stability, drug loading capacity, active targeting ability and lung local delivery potential, and can be used for preparing inhalation preparations or local administration preparations for treating lung cancer.

The application provides an information association method and device, electronic equipment and storage medium, relates to the technical field of communication, and solves the technical problem that in the related art, other users cannot guarantee the security of service data based on the terminal corresponding to a user accessing related services. The method comprises the following steps: receiving an information association request sent by a terminal; in the case that the secret card identifier of the first secret card is the same as the secret card identifier included in the opening information of the first account, and the first field included in the opening information of the first account is empty, sending a first verification code to the terminal, the first field being used to represent the terminal identifier corresponding to the account identifier of the first account; in the case that the first verification code sent by the terminal is received, determining the terminal identifier of the terminal as the terminal identifier corresponding to the account identifier of the first account, and determining the secret card identifier of the first secret card as the secret card identifier corresponding to the account identifier of the first account.

The invention discloses a preparation method of glycosylated bamboo shoot peptide chelated calcium. Combining the bamboo shoot cleaning solution with the filtrate, carrying out alkali dissolution and acid precipitation, collecting precipitates, dispersing the precipitates in ultrapure water, and carrying out spray drying to obtain bamboo shoot protein powder; taking the bamboo shoot protein, adding alkaline protease, carrying out enzymolysis reaction, and carrying out ultrafiltration and freeze drying; the preparation method comprises the following steps: mixing BSH with six different saccharides, and dissolving in deionized water to prepare a solution; preparing BSH with similar grafting degrees and same time; cooling, filtering, and freeze-drying trapped fluid to obtain a BSH sample; mixing the glycosylated BSH solution with calcium chloride, and adding absolute ethyl alcohol to obtain glycosylated BSH-Capowder; the calcium binding capacity of the bamboo shoot peptide is effectively improved, an experimental basis is provided for development of BSH-Ca and XY-BSH-Ca as calcium supplements and functional peptide additives, the high-value utilization approach of bamboo shoot resources is expanded, and a new thought is provided for research and development of novel efficient calcium supplements.

The application relates to the technical field of information security, in particular to a method for encrypting and transmitting information, which comprises the following steps: providing initial information to be encrypted, randomly generating an initial key, adding padding bytes to the initial information to be encrypted through a padding method to obtain padding plaintext, and performing first encryption on the padding plaintext through a symmetric encryption algorithm to obtain first encryption ciphertext; determining the encryption times of second encryption and the encryption method of second encryption according to the initial key, and performing second encryption on the first encryption ciphertext to obtain second encryption ciphertext; performing verification calculation on the second encryption ciphertext to obtain verification information, and inserting the verification information into the second encryption ciphertext in segments according to the key to obtain third encryption ciphertext; and transmitting the third encryption ciphertext. The method for encrypting and transmitting information provided by the application improves the security of information in the transmission process.

This invention discloses a CH@SHP099-NPs composite hydrogel, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the technical challenge of achieving long-term, safe, and precise metabolic intervention with SHP2, this invention constructs a hydrogel system composed of chondroitin sulfate and hyaluronic acid. This system can retain SHP099-loaded nanoparticles within the joint cavity, forming a long-acting intrasynovial drug library, thereby continuously inhibiting the SHP2-AMPK signaling axis. The CH@SHP099-NPs composite hydrogel prepared in this invention can effectively reprogram the metabolic state of macrophages, reduce glycolysis flux, restore synovial immune metabolic homeostasis, and significantly improve synovial inflammation, chondrocyte activity, and cartilage structural integrity in vivo. This invention proposes a mechanism-guided local delivery metabolic intervention strategy, which is expected to provide a new interventional approach for the treatment of osteoarthritis.