2results about How to "Verify security" patented technology

This invention discloses a CH@SHP099-NPs composite hydrogel, its preparation method, and its applications, belonging to the field of biomedical technology. Addressing the technical challenge of achieving long-term, safe, and precise metabolic intervention with SHP2, this invention constructs a hydrogel system composed of chondroitin sulfate and hyaluronic acid. This system can retain SHP099-loaded nanoparticles within the joint cavity, forming a long-acting intrasynovial drug library, thereby continuously inhibiting the SHP2-AMPK signaling axis. The CH@SHP099-NPs composite hydrogel prepared in this invention can effectively reprogram the metabolic state of macrophages, reduce glycolysis flux, restore synovial immune metabolic homeostasis, and significantly improve synovial inflammation, chondrocyte activity, and cartilage structural integrity in vivo. This invention proposes a mechanism-guided local delivery metabolic intervention strategy, which is expected to provide a new interventional approach for the treatment of osteoarthritis.

The application provides an information association method and device, electronic equipment and storage medium, relates to the technical field of communication, and solves the technical problem that in the related art, other users cannot guarantee the security of service data based on the terminal corresponding to a user accessing related services. The method comprises the following steps: receiving an information association request sent by a terminal; in the case that the secret card identifier of the first secret card is the same as the secret card identifier included in the opening information of the first account, and the first field included in the opening information of the first account is empty, sending a first verification code to the terminal, the first field being used to represent the terminal identifier corresponding to the account identifier of the first account; in the case that the first verification code sent by the terminal is received, determining the terminal identifier of the terminal as the terminal identifier corresponding to the account identifier of the first account, and determining the secret card identifier of the first secret card as the secret card identifier corresponding to the account identifier of the first account.