The invention provides a hospital medical insurance expense nonpayment prevention auxiliary management information system, which comprises a management server and a user end, wherein the management server comprises a nonpayment prevention patient database, and an expense nature setting module, a drug attribute setting module, a patient information recognition module, a drug usage day prompt module, a reimbursement category setting module, a medical insurance policy information prompt module, a self-paying protocol verification module and a printing module communicating with the nonpayment prevention patient database. The drug usage days of the patient can be counted, a doctor is prompted when the drug usage days exceed, indication judgment can be carried out on drugs prescribed by the doctor, the drug usage indication is prompted to the doctor, the doctor can thus inform the patient or a family member, happening of the expense nonpayment possibility can be prevented from the source, convenience is provided for the doctor, medical disputes can be avoided, management by the hospital is facilitated, and obvious economic benefits are brought to the hospital.