37 results about "Retinal structure" patented technology

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

Systems and methods are provided for disrupting tissue within preretinal or retinal structures of an eye. At least one femtosecond laser pulse is directed through the cornea of the eye to a target location. The at least one femtosecond laser pulse has sufficient intensity to induce nonlinear absorption in tissue within the target location. The at least one laser pulse is corrected at an adaptive optical element as to substantially reduce dispersion and aberration of the at least one laser pulse due to changes in the wavefront profile associated with the laser pulse due to travel through eye tissue between the surface of the eye and the target location. At least the target location is imaged to produce an in vivo image of the target location. The adaptive optical element is adjusted according to distortion detected in a reflected wavefront.

The invention relates to a dual-wavelength retinal vessel blood oxygen measuring system based on a fundus camera. The system comprises two parts, namely, a retinal image acquisition subsystem and a blood oxygen calculation subsystem, wherein the retinal image acquisition subsystem forms a retinal image acquired by the fundus camera to infinity through an imaging objective, and a telecentric beam path in the image space is formed. A right-angled reflecting prism splits a light beam into two ways, the light beam is reflected by reflectors and transmits interference filters with specific wavelengths to be filtered into imaging light with required wavelengths, the imaging light is imaged on a CCD (charge coupled device) target surface simultaneously after passing through the imaging objective, and dual-wavelength simultaneous retinal imaging is realized; the blood oxygen calculation subsystem finishes calculation of the retinal vessel blood oxygen saturation after performing a series of operations such as image processing, vessel extraction, light density calculation and the like on an acquired dual-wavelength retinal image. With the adoption of the system, retinal vessel function information is acquired while the retinal structure image is acquired, and a powerful tool can be provided for life science related research and diagnosis of fundus related diseases.

Methods and systems are presented to analyze a retinal image of an eye and assigns features to known anatomical structures such as retinal layers. One example method includes receiving interferometric image data of an eye. A set of features is identified in the image data. A first subset of identified features is associated with known retinal structures using prior knowledge. A first set of characteristic metrics is determined of the first subset of features. A second set of characteristic metrics is determined of a second subset of features. Using the characteristic metrics of the first and the second sets, the second subset of features is associated with the retinal structures. Another example method includes dividing interferometric image data into patches. The image data in each patch is segmented to identify one or more layer boundaries. The segmentation results from each patch are stitched together into a single segmentation dataset.

The present disclosure provides a method for acquiring a retina structure from an optical coherence tomographic image and a system thereof. The method comprises: calculating a region of interest (ROI) image of a source image; performing a Gaussian filtering of the ROI image; calculating a first estimated boundary position of a first layer boundary and a second estimated boundary position of a second layer boundary using a multi-resolution method; refining the first layer boundary and the second layer boundary respectively using a simplified active contour model according to the first estimated boundary position and the second estimated boundary position, to obtain a first initial boundary position of the first layer boundary and a second initial boundary position of the second layer boundary; smoothing the first initial boundary position and the second initial boundary position using a filtering method; acquiring segmentation positions of rest layer boundaries in the ROI image according to a segmented position of the first layer boundary and a segmented position of the second layer boundary. The present disclosure can improve the calculation speed and reduce the calculation complexity while maintaining high location accuracy.

The invention relates to a high-resolution retinal imaging method and device notably comprising an emission source (LSr) for emitting a light beam for the illumination of the retina of an eye (10) of a subject, a detection device (12) capable of detecting spatial-frequency structures of 250 cycles/mm measured in the plane of the retina, an optical imaging system (16) allowing for the formation of an image of at least a part of the retina on the detection device (12), a device (15) for measuring optical defects with an analysis plane of the optical defects, a correction device (14) comprising a correction plane and intended to correct, in said correction plane, the light rays from said emission source (LSr) and backscattered by the retina as a function of the optical defects measured by the measurement device (15). The correction and analysis planes are optically conjugated with a predetermined plane (17) of the eye, and the input pupil of said optical imaging system has a diameter of between a first value Φmin and a second value Φmax, the first value being defined to allow for the detection by said detection device (12), at an imaging wavelength, of structures of the retina exhibiting a spatial frequency of 250 cycles per millimeter, and the second value being less than 5.75 mm.

The invention discloses a cataract OCT image restoration method and system based on machine learning. The cataract OCT image restoration method introduces an optical information processing technology, changes the frequency spectrum of an object through an optical spatial filter, carries out the amplitude, phase or composite filtering of an inputted image, and carries out the fuzzy processing of the image, thus achieving the simulation of a cataract OCT fuzzy image; then the neutral density attenuation sheet is added to an OCT scanner lens to scan healthy eyeballs, a fundus OCT blurred image is obtained to simulate a cataract image, then an OCT clear image of the same person without the attenuation sheet is scanned, and the cataract retina OCT blurred image is restored into a clear image. The ten layers of retina structures can be clearly seen from the restored image, and the number of network models is reduced, so that the workload and the total training time are reduced, and the technology of restoring the blurred image to be clear is realized only by using the Pix2pix model.

Methods and apparatus for imaging multiple retinal structures and montaging of multiple retinal images are provided. The method involves cross-correlating images from different imaging channels to compensate for intra-frame distortion due to retinal movement during image acquisition, and conducting a second cross-correlation to filter out any motion artifacts in the images. The resultant images are combined to generate a composite image. The method also involves controlling light directed on the retina spatially and temporally.

The invention is suitable for technical field of health-care food and provides a compound soft capsule for relieving asthenopia, improving eyesight, resisting oxidation and protecting retina and a preparation method. The compound soft capsule comprises a content and a capsule skin; the content comprises the following materials in parts by weight: 38-50 parts of xanthophyll extract, 155-180 parts of procyanidine extract, 255-270 parts of soybean oil and 14-23 parts of beewax; the capsule skin comprises the following materials in parts by weight: 230-260 parts of gelatin, 118-130 parts of glycerinum, 235-260 parts of deionized water and 1-2 parts of titanium oxide. In the compound soft capsule, the xanthophyll extract and the procyanidine extract extracted from natural plants are combined with materials, such as soybean oil and beewax. The xanthophyll extract and the procyanidine extract have a synergistic effect, have excellent oxidation resistance, are capable of effectively removing free radicals and restraining the generation and lipid peroxidation of crystalline oxygen radicals, and meanwhile supplementing the xanthophyll required by human body, have an excellent protecting function for retina structure, can effectively relieve eye uncomfortable symptoms, such as asthenopia, and have high safety.

The invention discloses a biologic sclera contraction band and a preparing method thereof. The biologic sclera contraction band is in a band as a whole; the cross section of the biologic sclera contraction band is arc-shaped; the biologic sclera contraction band is thickest in the middle and gradually becomes narrower from the middle to the two sides through arc-shaped transition; the whole length of the biologic sclera contraction band is 3-40mm; the middle thickness of the biologic sclera contraction band is 1-3mm; the thickness of the two sides of the biologic sclera contraction band is 0.5-2mm; the band width of the biologic sclera contraction band is 3-8mm. The biologic sclera contraction band can be applied to combination with a biologic posterior sclera reinforcing band, can contract sclera and limit the expansion of the sclera, is used for treating high myopia macular retinal detachment, full retinal detachment and other certain non-incremental retinal detachments and better keeps and protects retinal structures and functions. The base material of the biologic sclera contraction band is taken from the trachea, ligament, trunk vessel or cartilage of an animal, the strength is increased through genipin cross-linking solidifying treatment, the elasticity and the hardness are proper, and the biologic sclera contraction band cannot be easily absorbed, has great tissue compatibility, causes few complications and overcomes the defects of the conventional retinal detachment intra and extra surgeries.

Systems, methods, and computer readable media for determining cognitive impairment (CI) in patients are provided herein. Various regional structural-functional parameters of the retina can serve as biomarkers for the detection of CI. The method can include forming a database including a quantification of retinal structure and retinal function of a plurality of eyes associated with a plurality of patients, providing a baseline cognitive impairment (CI) reference. The method can include determining a measure of functionality of neurons in the retina based on an electroretinogram (ERG) of a patient. The method can include determining a structural measure of the first retina based on a generalized dimension spectrum and singularity spectrum of the skeletonized retinal image, and a lacunarity parameter of the skeletonized retinal image. The method can include determining a level of cognitive impairment based on the structural and functional measures.

A device for determining biometric variables of the eye, as are incorporated in the calculation of intraocular lenses including a multi-point keratometer and an OCT arrangement. The keratometer measurement points are illuminated telecentrically and detected telecentrically and the OCT arrangement is designed as a laterally scanning swept-source system with a detection region detecting the whole eye over the whole axial length thereof. The multi-point keratometer ensures that a sufficient number of keratometer points are available for measuring the corneal surface. By contrast, telecentricity ensures that the positioning inadequacies of the measuring instrument in relation to the eye to be measured do not lead to a local mismatch of the reflection points. The swept-source OCT scan detects the whole eye over the length thereof so that both anterior chamber structures and retina structures can be detected and a consistent whole eye image can be realized.

The invention relates to application of tripterine to preparation of medicine treating degenerative retinopathy related diseases. A mouse model suffering from retinal photodamage is adopted to simulate a common pathological link in various degenerative retinopathy generation processes, that is, death of photoreceptor cells; the photoreceptor cell death preventing function and the degenerative retinopathy preventing function of tripterine are researched, wherein the results show that tripterine can be used for inhibiting mass dead of the photoreceptor cells and structural damage and functional injury of a retina caused by photodamage, and is very obvious in degenerative retinopathy treating effect. Therefore, tripterine can be used for preparing medicine treating various types of degenerative retinopathy including age related macular degeneration, retinitis pigmentosa, Stargardt disease, cone-rod dystrophy, diabetic retinopathy and the like, or preparation of reagents used in related scientific researches.

An optical apparatus uses polarized light to interrogate birefringence properties of the retina to detect the fixation condition of the eye by sensing characteristic birefringence patterns of the retinal structures. Optical components, as well as optional additional components, interfere with the polarization measurements by introducing unwanted retardance which alters the polarization state of the light entering the eye and of the light reaching the detection system. Compensating retarders are provided to nullify the effect of unwanted retardance in the forward and return light paths so the polarization states of the light entering the eye and the light reaching the detection system are not contaminated by the effects of the unwanted retardance. Mueller matrices are used to mathematically calculate the parameters for the compensating retarders for the unwanted retardance. A variable retarder system may also be provided to compensate for the corneal birefringence of the eye via feedback control.

The present invention relates to an eye phantom for evaluating a retinal angiography image, and a manufacturing method therefor. A purpose of the present invention is to provide an eye phantom for evaluating a retinal angiography image, capable of simulating even the vascular structure and blood flow of a retina so as to be more similar to an actual retinal structure than a conventional eye phantom; and a manufacturing method therefor. More specifically, a purpose of the present invention is to provide an eye phantom for evaluating a retinal angiography image, including various shapes of fine fluid channel structures corresponding to the vascular structure formed in an actual retina; and a manufacturing method therefor.

The present invention refers to the field of ophthalmology, and in particular to that of devices and methods for supporting the diagnosis of important eye pathologies such as Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), anomalies and dysfunctions of the retina and of sight in general such as degeneration of the retinal structure of the optical nerve and of the visual cortex. More specifically, the invention concerns a new device and method for recording the electroretinogram (so-called ERG) of an eye, i.e. the bioelectric response of the retina induced by a light stimulus, through the eyelid.