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286 results about "Macula Lutea" patented technology

An oval area in the retina, 3 to 5 mm in diameter, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototropic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed)

Enhanced optical coherence tomography for anatomical mapping

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
Owner:UNIV OF MIAMI

Methods and apparatus for sub-retinal catheterization

Devices and methods are provided for access to the sub-retinal space that lies between the retina and the choroid in order to introduce therapies to the retina and more specifically to the sensory retina and RPE, particularly in the region of the macula. The devices comprise a catheter that incorporates advantageous size, flexibility and tip features to properly, accurately and atraumatically access the sub-retinal space. Ancillary devices to assist in placing catheters into the sub-retinal space are also provided. The catheter devices incorporate a lumen for delivery of therapeutic substances or devices into the eye.
Owner:ISCI INTERVENTIONAL CORP

Enhanced optical coherence tomography for anatomical mapping

ActiveUS20060119858A1Enhanced anatomical mappingReduction in total information contentEye diagnosticsUsing optical meansData setSpectral domain
A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.
Owner:UNIV OF MIAMI

Management of ophthalmologic disorders, including macular degeneration

InactiveUS20060069078A1A2E production can be reducedInhibit bindingBiocideSenses disorderDiseaseRod Photoreceptor Cells
A drug may be used in the preparation of a medicament for the treatment or prevention of an ophthalmologic disorder, wherein the drug inihibits, antagonizes, or short-circuits the visual cycle at a step of the visual cycle that occurs outside a disc of a rod photoreceptor cell.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE

Pattern analysis of retinal maps for the diagnosis of optic nerve diseases by optical coherence tomography

Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.
Owner:USC STEVENS UNIV OF SOUTHERN CALIFORNIA

Apparatus and methods for prevention of age-related macular degeneration and other eye diseases

Surgical apparatus and surgical methods are proposed for the prevention of age-related macular degeneration (AMD) and choroidal neovascularization (CNV), and other eye diseases such as glaucoma by removal of the sclera tissue to reduce its rigidity and increase the flood flow and decrease pressure in the choriocapillaris. The disclosed preferred embodiments of the system consists of a tissue ablation means and a control means of ablation patterns and a fiber delivery unit. The basic laser beam includes UV lasers and infrared lasers having wavelength ranges of (0.15-0.36) microns and (0.5-3.2) microns and diode lasers of about 0.98, 1.5 and 1.9 microns. AMD and CNV are prevented, delayed or reversed by using an ablative laser to ablate the sclera tissue in a predetermined patterns outside the limbus to increase the elasticity of the sclera tissue surrounding the eye globe The surgery apparatus also includes non-laser device of radio frequency wave, electrode device, bipolar device and plasma assisted device
Owner:LIN J T

Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids

Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in photoreceptor-degenerated retina in an animal model. Such treatment restored visual perception and various aspects of vision. A method of restoring light sensitivity to a retina of a subject suffering from vision loss due to photoreceptor degeneration, as in retinitis pigmentosa or macular degeneration, is provided. The method comprises delivering to the subject by intravitreal or subretinal injection, the above nucleic acid vector which comprises an open reading frame encoding a rhodopsin, to which is operatively linked a promoter and transcriptional regulatory sequences, so that the nucleic acid is expressed in inner retinal neurons. These cells, normally light-insensitive, are converted to a light-sensitive state and transmit visual information to the brain, compensating for the loss, and leading to restoration of various visual capabilities.
Owner:WAYNE STATE UNIV +1

Methods and compositions for treating conditions of the eye

InactiveUS7125542B2Improve treatment efficacyReduced and delayed recurrenceUltrasonic/sonic/infrasonic diagnosticsBiocideAnti angiogenesisPhotosensitizer
Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.
Owner:MASSACHUSETTS EYE & EAR INFARY

Handheld reflectometer for measuring macular pigment

A macular pigment reflectometer is handheld, light, and portable. It can be provided as a part of a self-contained system. The self-contained system includes a docking station in which the macular pigment reflectometer is placed between uses. The docking station is used to recharge the battery of the handheld macular pigment reflectometer. The docking station also has one or more types of communication ports, such as one for a wired or wireless internet connection, through which the handheld macular pigment reflectometer can communicate with a computer or an electronic medical records system. The instrument operates in a pulsed operating mode wherein relative instrument-to-eye motion is reduced and, preferably, nearly eliminated. The handheld macular pigment reflectometer contains an on-board spectrometer which is designed to capture spectra in very short intervals of time. A trigger on the instrument allows for a rapid, intuitive, and sequential alignment followed by rapid data gathering.
Owner:OCULAR PROGNOSTICS

Raav vector compositions and methods for the treatment of choroidal neovascularization

InactiveUS20060193830A1Prevention of variousTreatment of variousBiocideSenses disorderPIGMENT EPITHELIUM-DERIVED FACTORDisease
Disclosed are methods for the use of therapeutic polypeptide-encoding polynucleotides in the creation of transformed host cells and transgenic animals is disclosed. In particular, the use of recombinant adeno-associated viral (rAAV) vector compositions comprising polynucleotide sequences that express one or more mammalian PEDF or anti-angiogenesis polypeptides is described. In particular, the invention provides gene therapy methods for the prevention, long-term treatment and / or amelioration of symptoms of a variety of conditions and disorders in a mammalian eye, including, for example blindness, loss of vision, retinal degeneration, macular degeneration, and related disorders resulting from retinal or choroidal neovascularization in affected individuals.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE +1

Pattern analysis of retinal maps for the diagnosis of optic nerve diseases by optical coherence tomography

Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.
Owner:USC STEVENS UNIV OF SOUTHERN CALIFORNIA

Light management for image and data control

A multi-component method and device for improving vision for some with low vision conditions including age related macular degeneration (AMD) is disclosed. A plurality of co-pathological conditions that together make undistorted, clear and bright vision challenging are dealt with by managing the nature, amounts and patterns of light provided to the eye in a display embodiment. For example, a worn embodiment, in providing an improved image of the view ahead, modifies the frequency mix of incoming light, the relative intensities of light to different retinal locations and the color perception of the wearer while undistorting certain kinds of progressive distortion.
Owner:SIMMONS JOHN CASTLE

Macula lutea image detection method and equipment

The invention provides a macula lutea image detection method and equipment. The macula lutea image detection method comprises the steps that a fundus image is acquired; a machine learning model is utilized to recognize the fundus image to output the fundus image obtained after feature regions are marked, wherein the feature regions are at least one of a macula lutea region, an optic disc region and a macula lutea and optic disc united region, and the machine learning model is obtained by performing training through sample images at the positions of the known feature regions; and according to the fundus image obtained after the feature regions are marked, the fundus image obtained after a macula lutea image position is marked is output.
Owner:SHANGHAI EAGLEVISION MEDICAL TECH CO LTD

Lenticular refractive surgery of presbyopia, other refractive errors, and cataract retardation

Methods for the creation of microspheres treat the clear, intact crystalline lens of the eye with energy pulses, such as from lasers, for the purpose of correcting presbyopia, other refractive errors, and for the retardation and prevention of cataracts. Microsphere formation in non-contiguous patterns or in contiguous volumes works to change the flexure, mass, or shape of the crystalline lens in order to maintain or reestablish the focus of light passing through the ocular lens onto the macular area, and to maintain or reestablish fluid transport within the ocular lens.
Owner:SECOND SIGHT LASER TECH

Circular preferential hyperacuity perimetry video game to monitor macular and retinal diseases

ActiveUS20150190048A1PhoroptersDiseaseFixation point
Systems and methods for providing a video game to map macular visual acuity comprising a test where a fixation point is ensured by brief simultaneous presentation of central and pericentral targets. The game may be implemented on a hardware platform including a video display, a user input device, and a video camera. The camera is used to monitor ambient light level and the distance between the device and the eyes of the test subject. The game serves as a macular acuity perimeter that produces a map of the acuity of an eye that may be compared with normative data. The type of acuity tested is preferably Vernier acuity, but resolution acuity can also be tested. The test results are transmitted to a health care professional by telecommunications means to facilitate the diagnosis or monitoring of age-related macular degeneration or other relevant eye diseases.
Owner:GOBIQUITY INC

Orthovoltage radiosurgery

InactiveUS20080247510A1Dry up neovascular membraneStabilized and improved acuityHandling using diaphragms/collimetersRadiation diagnosticsRadiosurgeryDisease
A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and / or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
Owner:CARL ZEISS MEDITEC INC

Intraocular lens

ActiveUS20150005877A1Negative impactUndesirable appearanceIntraocular lensIntraocular lensOptical axis
An intraocular lens includes an optic, which includes a first lens having a first optical axis for alignment with an optical axis of the human eye having a macula; and a second lens having a second optical axis. The second optical axis and the first optical axis enclose an angle between 0.5 and 10 degrees. The first and second lens are arranged next to one another in a direction transverse to the first optical axis to provide no overlap in a direction along the first optical axis such that the first lens and the second lens each, independent from one another, image onto the macula of the eye. The angle and a direction of the second optical axis are chosen such that the second lens images onto a functional part of the macula of the human eye, which functional part is not compromised by a defect, such as a scotoma.
Owner:TELEON HLDG BV

Application of fusion protein of VEGF receptor for treating disease of eye

An application of the receptor fusion protein VEGF in treating eye diseases including the age associated macula lutea lesion, retinosis of diabetic, xanthelasma of diabetic, etc is disclosed.
Owner:CHENGDU KANGHONG BIOTECH

Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells

Provided are methods and compositions for maintaining the viability of photoreceptor cells and / or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (AMD) (e.g., dry or neovascular AMD), retinitis pigmentosa (RP), or a retinal detachment. The viability of the photoreceptor cells and / or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. The compositions, when administered, maintain the viability of the cells, thereby minimizing the loss of vision or visual function associated with the ocular disorder.
Owner:VAVVAS DEMETRIOS +3

Methods and apparatus for sub-retinal catheterization

Devices and methods are provided for access to the sub-retinal space that lies between the retina and the choroid in order to introduce therapies to the retina and more specifically to the sensory retina and RPE, particularly in the region of the macula. The devices comprise a catheter that incorporates advantageous size, flexibility and tip features to properly, accurately and atraumatically access the sub-retinal space. Ancillary devices to assist in placing catheters into the sub-retinal space are also provided. The catheter devices incorporate a lumen for delivery of therapeutic substances or devices into the eye.
Owner:ISCI INTERVENTIONAL CORP

Multiple target point small interference RNA cocktail agent for treating ophthalmic disease and preparing method thereof

The invention discloses a multi-target small-interfering RNA cocktail preparation for treating ophthalmic diseases and the preparation method. The multi-target small-interfering-RNA cocktail preparation is composed of three or more than three small-interfering RNA aiming to three or more than three different genes and knocking down simultaneously a plurality of pathogenic genes; the multi-target small-interfering-RNA cocktail preparation is prepared by a plurality of small-interfering RNA in a certain proportion according to different diseases. The multi-target small-interfering-RNA cocktail preparation is a plurality of double-bond RNA molecules of different lengths from 19to 27nt, with blunt ends or overhanging ends; the RNA sequence in the multi-target small-interfering-RNA cocktail preparation has the homology to the gene targets of human, rat and other nonhuman primate; . The multi-target small-interfering-RNA cocktail preparation aiming to the following gene sequences: (1) virus-affection-related gene; (2) inflammation-arosing gene; (3) neovescular-related gene. The invention provides a novel treatment for a plurality of ophthalmic diseases, including retinopathy of prematurity, senile fundus macula lutea, retinopathy caused by senile diabetes, herpes simplex corneal stromal opacification and uveitis.
Owner:广州拓谱基因技术有限公司

Health care product capable of resisting visual fatigue

The invention discloses a health care product capable of resisting visual fatigue. The health care product comprises, by weight, 30% of theanine, 69% of an anthocyanin extract and 1% of vitamin C. The invention also discloses an anti-visual fatigue health care capsule prepared from the health care product by dissolving 1000 g of the health care product with 5 L of water at room temperature, carrying out uniform mixing with stirring, then carrying out spray drying to obtain powder and packaging the powder with a capsule filling machine so as to obtain capsules, each weighing 200 mg. The health care product provided by the invention has the characteristics of no artificial chemical antiseptic, no toxic and side effect on a body and capacity of effective prevention and adjuvant therapy of retinopathy like glaucoma, nyctalopia, age-related macular degeneration (AMD) and cataract.
Owner:ZHEJIANG GONGSHANG UNIVERSITY

Macular and scleral support surgical device for ocular restraint in progressive high myopia

The present invention is a flexible ocular restraint band that includes a thin flexible material such as a surgical mesh fabric with flexible reinforced end portions. The device is positioned posterior to the eye globe and the reinforced ends are sutured to anterior portions of the scleral ring. Preferably, a side edge of the band is formed with a concave curved edge to be placed proximate the optical nerve without making contact or applying pressure to the optical nerve. When properly positioned the device prevents further axial elongation of the eye. In alternative embodiments the band may be formed as a generally linear strap, a three legged or “Y” shaped strap or a four legged “X” shaped strap.
Owner:WARD BRIAN

Eye nutrients formulation for prevention and cure of age-related cataract, macula lutea degradation and other eye disease , and its application method

InactiveCN1481804AReduced risk of recessionReduced risk of macular degenerationOrganic active ingredientsSenses disorderRutinCarotenoid
The present invention is one group of carotenoid antioxidant recipe comprising lutin and / or rutin ester, zeaxanthin and / or zeaxanthin ester and other antioxidant. Several medicinal and health care antioxidant products may be produced to avoid, delay or treat the harmful effect of the free radical caused by light, cigarette and hormone to eye, especially its crystalline lens and retina. The present invention is used mainly for the prevention and treatment of age relevant eye diseases, cataract, macular degeneration, etc. Dihydroxy carotenoid and other antioxidant are used to nourish crystalline lens and retina so as to enhance the capacity of eye, especially its crystalline lens and retina, in resisting the effect of outer negative factors.
Owner:JC (WUXI) CO INC

Blue-ray-level protective resin lens with refraction index of 1.67 and preparation method thereof

The invention relates to a blue-ray-level protective resin lens with the refraction index of 1.67. The blue-ray-level protective resin lens with the refraction index of 1.67 comprises a resin substrate with the refraction index of 1.67; the resin substrate is dip-coated with a hardened film; a first SiO2 film, a ZrO2 film, a second SiO2 film, a Ti2O3 film, an In2O3 film and a third SiO2 film are deposited on the surface of the hardened film in sequence. According to the resin lens disclosed by the invention, the effect of filtering blue rays with the wavelength of 400 to 500 nm can reach 45 to 50 percent; blue ray radiation can be filtered effectively; sharp pain, soreness and swelling of eyes can be reduced; eye dryness and eye fatigue can be reduced; cataract and macular degeneration can be prevented.
Owner:江苏硕延光学眼镜有限公司

Fundus image macular center positioning method and device, electronic equipment and storage medium

The invention provides a fundus image macular center positioning method and device, electronic equipment and a storage medium. The fundus image macular center positioning method comprises the steps that a fundus image to be detected is input into a fundus image detection model; obtaining a detection result of the fundus image detection model, wherein the detection result comprises an optic disc region and a corresponding first detection frame, a macular region and a corresponding second detection frame and confidence; calculating central point coordinates of the optic disk area according to the first detection frame and calculating central point coordinates of the macular area according to the second detection frame; and when the confidence coefficient is smaller than a preset confidence coefficient threshold, identifying whether the fundus image to be detected is a left eye fundus image or a right eye fundus image, and correcting the central point of the macular area by adopting different correction models. The problem of macular area detection failure caused by image quality, lesion shielding and the like in a macular positioning method based on deep learning is solved, and the dependence of macular center positioning and optic disc center positioning in a traditional method is eliminated.
Owner:PING AN TECH (SHENZHEN) CO LTD

Slit lamp grid pattern laser treatment adapter

Embodiments of the invention provide systems and methods for treating the retina and / or other areas of a patient's eye. The procedures may involve using one or more treatment beams (e.g., lasers) to cause photocoagulation or laser coagulation to finely cauterize ocular blood vessels and / or prevent blood vessel growth to induce one or more therapeutic benefits. In other embodiments, a series of short duration light pulses (e.g., between 5-15 microseconds) may be delivered to the retinal tissue with a thermal relaxation time delay between the pulse to limit the temperature rise of the target retinal tissue and thereby limit a thermal effect to only the retinal pigment epithelial layer. Such procedures may be used to treat diabetic retinopathy, macular edema, and / or other conditions of the eye. The treatment beam may be delivered within a treatment boundary or pattern defined on the retina of the patient's eye.
Owner:IRIDEX CORP

Classification model construction method and device used for macula degeneration region segmentation

The invention discloses a classification model construction method used for macula degeneration region segmentation. The method includes the following steps: selecting multiple fundus images, conducting graying processing on the fundus images to obtain multiple gray scale images, and sampling foregrounds and backgrounds of the gray scale images to obtain samples; adopting a generalized low-rank approximate method to obtain a transformation matrix, conducting dimension reduction on the samples on the basis of the transformation matrix, and obtaining a low-rank approximate matrix of the samples; adding label information into the low-rank approximate matrix of the samples to perform a supervision function, and constructing manifold regularization items; establishing a target function through the generalized low-rank approximate method and the manifold regularization items, solving the target function through an iterative optimization method, and obtaining an optimal transformation matrix and an optimal low-rank approximate matrix of the samples; and constructing a classification model on the basis of the optimal low-rank approximate matrix and the label information. The classification model can extract low dimensional and also highly distinguishable feature descriptors, and can improve the segmentation precision.
Owner:SHANDONG NORMAL UNIV
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