269 results about "Macula Lutea" patented technology

A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye without first requiring a full segmentation of the 3-D data set. Advantageously, the system, method and apparatus of the present invention can provide quantitative three-dimensional information about the spatial location and extent of macular edema and other pathologies. This three-dimensional information can be used to determine the need for treatment, monitor the effectiveness of treatment and identify the return of fluid that may signal the need for re-treatment.

Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in photoreceptor-degenerated retina in an animal model. Such treatment restored visual perception and various aspects of vision. A method of restoring light sensitivity to a retina of a subject suffering from vision loss due to photoreceptor degeneration, as in retinitis pigmentosa or macular degeneration, is provided. The method comprises delivering to the subject by intravitreal or subretinal injection, the above nucleic acid vector which comprises an open reading frame encoding a rhodopsin, to which is operatively linked a promoter and transcriptional regulatory sequences, so that the nucleic acid is expressed in inner retinal neurons. These cells, normally light-insensitive, are converted to a light-sensitive state and transmit visual information to the brain, compensating for the loss, and leading to restoration of various visual capabilities.

Negatively charged phospholipids, as well as compositions including negatively charged phospholipids and possibly carotenoids and/or antioxidants, for treating the eye are disclosed. In a preferred embodiment, a composition comprising at least one negatively charged phospholipid except cardiolipin is used to treat age-related macular degeneration. Methods for producing the negatively charged phospholipids, as well as methods for producing the compositions including negatively charged phospholipids and possibly carotenoids and/or antioxidants for treating age-related macular degeneration, are also disclosed.

Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.

A macular pigment reflectometer is handheld, light, and portable. It can be provided as a part of a self-contained system. The self-contained system includes a docking station in which the macular pigment reflectometer is placed between uses. The docking station is used to recharge the battery of the handheld macular pigment reflectometer. The docking station also has one or more types of communication ports, such as one for a wired or wireless internet connection, through which the handheld macular pigment reflectometer can communicate with a computer or an electronic medical records system. The instrument operates in a pulsed operating mode wherein relative instrument-to-eye motion is reduced and, preferably, nearly eliminated. The handheld macular pigment reflectometer contains an on-board spectrometer which is designed to capture spectra in very short intervals of time. A trigger on the instrument allows for a rapid, intuitive, and sequential alignment followed by rapid data gathering.

A multi-component method and device for improving vision for some with low vision conditions including age related macular degeneration (AMD) is disclosed. A plurality of co-pathological conditions that together make undistorted, clear and bright vision challenging are dealt with by managing the nature, amounts and patterns of light provided to the eye in a display embodiment. For example, a worn embodiment, in providing an improved image of the view ahead, modifies the frequency mix of incoming light, the relative intensities of light to different retinal locations and the color perception of the wearer while undistorting certain kinds of progressive distortion.

The invention provides a macula lutea image detection method and equipment. The macula lutea image detection method comprises the steps that a fundus image is acquired; a machine learning model is utilized to recognize the fundus image to output the fundus image obtained after feature regions are marked, wherein the feature regions are at least one of a macula lutea region, an optic disc region and a macula lutea and optic disc united region, and the machine learning model is obtained by performing training through sample images at the positions of the known feature regions; and according to the fundus image obtained after the feature regions are marked, the fundus image obtained after a macula lutea image position is marked is output.

The invention discloses a multi-target small-interfering RNA cocktail preparation for treating ophthalmic diseases and the preparation method. The multi-target small-interfering-RNA cocktail preparation is composed of three or more than three small-interfering RNA aiming to three or more than three different genes and knocking down simultaneously a plurality of pathogenic genes; the multi-target small-interfering-RNA cocktail preparation is prepared by a plurality of small-interfering RNA in a certain proportion according to different diseases. The multi-target small-interfering-RNA cocktail preparation is a plurality of double-bond RNA molecules of different lengths from 19to 27nt, with blunt ends or overhanging ends; the RNA sequence in the multi-target small-interfering-RNA cocktail preparation has the homology to the gene targets of human, rat and other nonhuman primate; . The multi-target small-interfering-RNA cocktail preparation aiming to the following gene sequences: (1) virus-affection-related gene; (2) inflammation-arosing gene; (3) neovescular-related gene. The invention provides a novel treatment for a plurality of ophthalmic diseases, including retinopathy of prematurity, senile fundus macula lutea, retinopathy caused by senile diabetes, herpes simplex corneal stromal opacification and uveitis.

The invention discloses a health care product capable of resisting visual fatigue. The health care product comprises, by weight, 30% of theanine, 69% of an anthocyanin extract and 1% of vitamin C. The invention also discloses an anti-visual fatigue health care capsule prepared from the health care product by dissolving 1000 g of the health care product with 5 L of water at room temperature, carrying out uniform mixing with stirring, then carrying out spray drying to obtain powder and packaging the powder with a capsule filling machine so as to obtain capsules, each weighing 200 mg. The health care product provided by the invention has the characteristics of no artificial chemical antiseptic, no toxic and side effect on a body and capacity of effective prevention and adjuvant therapy of retinopathy like glaucoma, nyctalopia, age-related macular degeneration (AMD) and cataract.

The invention relates to a blue-ray-level protective resin lens with the refraction index of 1.67. The blue-ray-level protective resin lens with the refraction index of 1.67 comprises a resin substrate with the refraction index of 1.67; the resin substrate is dip-coated with a hardened film; a first SiO2 film, a ZrO2 film, a second SiO2 film, a Ti2O3 film, an In2O3 film and a third SiO2 film are deposited on the surface of the hardened film in sequence. According to the resin lens disclosed by the invention, the effect of filtering blue rays with the wavelength of 400 to 500 nm can reach 45 to 50 percent; blue ray radiation can be filtered effectively; sharp pain, soreness and swelling of eyes can be reduced; eye dryness and eye fatigue can be reduced; cataract and macular degeneration can be prevented.

The invention provides a fundus image macular center positioning method and device, electronic equipment and a storage medium. The fundus image macular center positioning method comprises the steps that a fundus image to be detected is input into a fundus image detection model; obtaining a detection result of the fundus image detection model, wherein the detection result comprises an optic disc region and a corresponding first detection frame, a macular region and a corresponding second detection frame and confidence; calculating central point coordinates of the optic disk area according to the first detection frame and calculating central point coordinates of the macular area according to the second detection frame; and when the confidence coefficient is smaller than a preset confidence coefficient threshold, identifying whether the fundus image to be detected is a left eye fundus image or a right eye fundus image, and correcting the central point of the macular area by adopting different correction models. The problem of macular area detection failure caused by image quality, lesion shielding and the like in a macular positioning method based on deep learning is solved, and the dependence of macular center positioning and optic disc center positioning in a traditional method is eliminated.

The invention discloses a lutein ophthalmic preparation for protecting eyesight, which is prepared from the following raw materials: 5 to 13 parts of water-soluble lutein (based on C4oH56O2), 50 to 80 parts of taurine, 0.1 to 0.5 parts of selenium (based on Se), 10 to 25 parts of zinc (based on Zn), 0.5 to 1.0 part of water-soluble vitamin A, and 0.8 to 2.0 parts of glutathione; an auxiliary material consists of a diluent, a wetting agent, an isoosmotic adjusting agent, a preservative, an antioxygen and water for injection; formulations comprise eye drops, eye lotion and the like; and the lutein ophthalmic preparation is suitable for eye diseases such as myopia, long sight, cataract, glaucoma, retinal pigment degeneration, macular degeneration and the like. Various nutritious factors are reasonably compatible, a blank of a lutein external preparation is filled, and the bioavailability and health-care effect are obviously improved; and through actual application by 300,000 people, the total effective rate for the myopia, cataract and diabetic eye disease is over 90 percent and the lutein ophthalmic preparation has positive promotion valve.

The invention relates to a microencapsulated preparation for protecting eyesight and a preparation method thereof. The preparation essentially comprises a microencapsulated effective component consisting of lutein and alpha-linolenic acid. The preparation method comprises the following steps: respectively preparing an oil phase solution and an aqueous phase solution; mixing and emulsifying the solutions to prepare emulsion, or further drying to prepare particles. Match of lutein and alpha-linolenic acid is an important contribution of the invention, both lutein and alpha-linolenic acid can be used for protecting eyesight, and alpha-linolenic acid can be used for transferring lutein to macula lutea, so that the effect of relieving asthenopia and protecting eyesight of the product can be greatly improved. The preparation can be used for preparing solid electuary, liquid preparation, tablet candy or preparations in other modes for relieving asthenopia and protecting eyesight according to requirements.

The invention provides a concocted milk powder for protecting eyes. The milk powder comprises the following components in percentage by weight: 40-50% of bovine milk powder or sheep milk powder, 20-35% of defatted bovine milk powder or defatted sheep milk powder, 5-10% of glucose syrup solid, 10-20% of desalted bovine whey powder or sheep milk powder, 0-18% of mixed vegetable oil, 5-10% of composite fruit and vegetable powder, 0-4% of fructo-oligosaccharides, 0.1-1% of compound vitamin, 0.0016-0.0050% of lutein, 0.0005-0.003% of zeaxanthin, 0.1-1% of compound minerals and 0.03-0.05% of taurine. The bovine milk powder or sheep milk powder can be replaced with fresh milk, and if the content of dry matters, namely the content of the bovine milk powder or the sheep milk powder is 12%, the composite fruit and vegetable powder contains 20wt% or above of blueberries and 20wt% or above of lycium ruthenicum. The invention also provides a preparation method of the concocted milk powder. The concocted milk powder of the invention is added with vitamin A, the lutein, the zeaxanthin, trace elements including zinc and selenium and the composite fruit and vegetable powder rich in anthocyanidin, so that the concocted milk powder has the effects of preventing the symptoms such as visual macula lutea damage, asthenopia and visual loss.

An image processing apparatus includes an alignment unit configured to align a first fundus oculi image that is an aberration-corrected image of an eye being examined and a second fundus oculi image having a larger view angle and a lower resolution than the first fundus oculi image, by using a third fundus oculi image having a smaller view angle and a higher resolution than the second fundus oculi image; a distance acquisition unit configured to acquire a distance from a macula lutea of the eye being examined to a certain position in the first fundus oculi image aligned by the alignment unit; and an evaluation unit configured to evaluate the state of the eye being examined from the distance and information concerning photoreceptor cells included in the first fundus oculi image.

A method of assessing the quality of an retinal image (such as a fundus image) includes selecting at least one region of interest within a retinal image corresponding to a particular structure of the eye (e.g. the optic disc or the macula), and a quality score is calculated in respect of the, or each, region-of-interest. Each region of interest is typically one associated with pathology, as the optic disc and the macula are. Optionally, a quality score may be calculated also in respect of the eye as a whole (i.e. over the entire image, if the entire image corresponds to the retina).

The invention relates to a circular bilateral Gabor filtering and local gradient analysis based automatic detection method for a microaneurysm in a color eye fundus image. The method comprises: firstly, preprocessing a green channel of the color eye fundus image; secondly, extracting candidates by adopting circular bilateral filtering and performing threshold segmentation to remove main blood vessels; and finally, calculating a local gradient direction histogram, removing tiny blood vessels according to the gradient direction anisotropy of the microaneurysm, calculating local contrast and roundness, and filtering out noises and bleeding points, thereby realizing the automatic detection of the microaneurysm. According to the method, the gray-level and structure information of the microaneurysm and the local gray-level difference of the tiny blood vessels are utilized, so that the influences of non-uniform illumination, low contrast and the tiny blood vessels can be overcome; the method not only can accurately detect large-sized, high-contrast and single-background microaneurysms but also has a very good detection effect on small-sized and low-contrast microaneurysms with complicated backgrounds close to blood vessels, yellow spots and the like; and finally the automatic detection of the microaneurysm is realized.