70 results about "Nonhuman primate" patented technology

The invention provides isolated non-human primate Fc receptor polypeptides, the nucleic acid molecules encoding the Fc receptor polypeptides, and the processes for production of recombinant forms of the Fc receptor polypeptides, including fusions, variants, and derivatives thereof. The invention also provides methods for evaluating the safety, efficacy and biological properties of Fc region containing molecules using the non-human primate Fc receptor polypeptides.

Using the MBGV GP, NP, and virion proteins, a method and composition for use in inducing an immune response which is protective against infection with MBGV in nonhuman primates is described.

The invention provides isolated non-human primate Fc receptor polypeptides, the nucleic acid molecules encoding the Fc receptor polypeptides, and the processes for production of recombinant forms of the Fc receptor polypeptides, including fusions, variants, and derivatives thereof. The invention also provides methods for evaluating the safety, efficacy and biological properties of Fc region containing molecules using the non-human primate Fc receptor polypeptides.

The invention discloses a non-human primate behavioral data acquisition device and a data acquisition method.The non-human primate behavioral data acquisition device comprises an animal movement device, a plurality of stereo cameras and an analysis terminal, wherein the animal movement device comprises a running machine, a hanging bracket, an animal strait coat and a plurality of fluorescent paints; the hanging bracket is erected above a running belt of the running machine, a hanging rod extending towards the running belt is arranged on the hanging bracket, a first ring buckle is arranged at the tail end of the hanging rod, a second ring buckle is arranged on the animal strait coat, and the first ring buckle and the second ring buckle are correspondingly buckled. The plurality of fluorescent paints are used for marking the joints; the number of the stereo cameras is not less than four, and the stereo cameras are arranged on the peripheral area of the running machine at intervals and used for collecting animal gait data and transmitting the data to the analysis terminal. The non-human primate behavioral gait data can be effectively collected, and the non-human primate behavioral gait data can be analyzed.

The invention discloses a methyl CpG binding protein 2-based (MECP2-based) method for injecting a virus into a specific brain area of an animal without a therapeutic aim to perform gene editing. A cerebral stereotaxis injection pump is utilized to directly inject the virus into the specific brain area of a non-human primate; the injection volume is that 1 [mu]L of virus is injected per 1m<3>; andthe titer of the injected virus is 10*10<13> vg / mL. According to the method, the virus is directly injected into the specific brain area of the non-human primate to perform gene editing, and thus, a transgenic monkey model with the disease phenotype can be obtained in a short time, and the urgent research demand of an autism spectrum disorder (ASD) disease at the present stage is met.

Systems, methods, and compositions for a diagnostic method for detecting TB in non-human primates that is easy to use, sensitive, and specific. The method utilizes recombinant mycobacterial antigens, such as polyfusion proteins. The method utilizes an antigen-antibody-antigen arrangement to detect TB infection in nonhuman primates. The method can detect IgM antibodies to TB, in addition to IgG antibodies, providing ability to detect TB earlier in nonhuman primate TB infection as compared to conventional TB tests.

The invention discloses an improved liftable novel monkey chair. The chair comprises a bearing device and a fixing device; the bearing device is used for bearing non-human primates to be detected; andthe fixing device is used for fixing the non-human primates to be detected on the bearing device. The improved liftable novel monkey chair is used for improving the convenience and data precision ofbehavioral experiments on non-human primates.

The invention relates to the technical field of non-human primate experimental animal disease models, and discloses an establishment method and application of a machin type 2 diabetes model. The method comprises the following steps of (1) selecting male machin of which the age is 12-21 years old; (2) feeding the male machin for four times every day, specifically, feeding the male machin with sugar-containing feed for the first time, feeding the male machin with complementary food for the second time, feeding the male machin with green feed for the third time and feeding the the male machin with the sugar-containing feed for the fourth time; and (3) after feeding the male machin for one year according to the mode in the step (2), detecting corresponding indexes, and selecting the machin with the blood glucose level larger than 7 mmol / L in the fasting state, wherein the fed complementary food is brown sugar blocks and biscuits alternately, and the brown sugar blocks and the biscuits are alternated once every three days; and the sugar-containing feed is obtained by mixing conventional feed and brown sugar. According to the method, the machin type 2 diabetes model is established by adopting a warm feeding mode, and the machin type 2 diabetes model can be used for drug effect evaluation in the research and development process of new drugs.

The invention relates to a device for accurately measuring the water intake of a non-human primate experimental animal. The device comprises a water drinking device body and a recycling water tank, wherein a water tank is arranged at the upper part of the water drinking device body, and a water drinking pipe control valve assembly is arranged at the lower part of the water drinking device body; the water drinking pipe control valve assembly comprises a backflow type water outlet head, a backflow cover, a connecting tube, a valve control arm and a lifting type water valve; the lower end of the backflow type water outlet head communicates with the left end of the connecting tube, and the backflow type water outlet head is obliquely distributed upwards relative to the connecting tube; a connecting tube rotating shaft support is correspondingly arranged in the water drinking device body, rotating shafts are correspondingly arranged on the outer walls of the two sides of the connecting tube, and the connecting tube can be rotationally distributed on the connecting tube rotating shaft support through the rotating shafts; and one end of the lifting type water valve communicates with the lower end of the water tank through a water outlet pipeline, and the other end of the lifting type water valve communicates with the right end of the connecting tube through a water supply hose. The device has the advantages of being accurate in metering, high in anti-interference capacity, easy to domesticate, good in using effect and the like.