Puncture device for pharmaceutical injection test

Abstract

The invention provides a puncture device for a pharmaceutical injection test, and relates to the technical field of medical experiments, the puncture device comprises a base mechanism, the base mechanism is fixed on a forearm of a non-human primate experiment body through a first medical adhesive tape and a second medical adhesive tape, and the base mechanism is fixedly provided with an injection tube through a locking mechanism; a middle connecting pipe is installed at one end of the injection pipe, a separation non-return hose is inserted into the end, away from the injection pipe, of the middle connecting pipe, and a needle mechanism is fixedly installed at the end, away from the middle connecting pipe, of the separation non-return hose. Through the cooperation of the base mechanism, the first medical adhesive tape, the second medical adhesive tape and the silica gel pad, comfortable and stable attachment of the device to the forearm of an experimental body is achieved, pulling caused by animal movement is effectively resisted, and through rigid locking of a threaded inclined plate and a fastening nut of the locking mechanism to an injection tube clamping convex ball, the clamping convex ball can be locked more firmly. And the reliability of connection between the infusion tube and the middle connecting tube is further ensured.

Description

Technical Field

[0001] This invention relates to the field of medical experimental technology, and in particular to a puncture device for pharmaceutical injection experiments. Background Technology

[0002] In non-human primate pharmaceutical injection experiments, indwelling needles are a key tool for ensuring the accuracy and reliability of experimental data. They enable stable, continuous, or timed drug infusion and allow for frequent, painless blood sampling. This is crucial for accurately studying drug pharmacokinetics, duration of action, and toxic reactions. Using indwelling needles minimizes pain, stress, and potential tissue damage to animals caused by repeated punctures. This aligns with the "3R" principles of animal protection and helps maintain the stability of the animal's physiological state, preventing stress responses from interfering with experimental results. Indwelling needles provide a stable and reliable vascular access for long-term or complex dosing regimens, significantly reducing the operational risks caused by animal struggles and improving experimental efficiency and personnel safety.

[0003] In existing technologies, during intravenous drug administration experiments on non-human primates, traditional fixation methods often rely on limited adhesive tape, which is difficult to adapt to the animals' vigorous and frequent activities. The tape is prone to loosening or skin oil seepage, causing the entire device to shift or even fall off completely, seriously affecting the stability of the indwelling device. Furthermore, the connection between the infusion tubing and the indwelling needle often uses simple plugs or Luer connectors, which are prone to loosening or leakage when subjected to multi-angle traction. This not only leads to waste of drug solution and inaccurate dosage but may also cause experimental interruption. Improvements are needed. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art. Through the stable fit between the base mechanism and the medical tape one, medical tape two and silicone pad, the rigid locking mechanism for the injection tube clamping ball, and the fitting of the intermediate tube limiting ring with the support and the auxiliary fixation of the medical tape three, the device's ability to resist the pulling and twisting of animal activities is enhanced. In addition, the one-way valve effect of the detachment check tube ensures the overall reliability of use.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a puncture device for pharmaceutical injection testing, comprising a base mechanism, wherein the base mechanism is fixed to the forearm of a non-human primate experimental subject by medical tape one and medical tape two, an injection tube is fixed to the base mechanism by a locking mechanism, an intermediate tube is installed on one end of the injection tube, a release check tube is inserted into the end of the intermediate tube away from the injection tube, and a needle mechanism is fixedly installed on the end of the release check tube away from the intermediate tube. The intermediate tube includes a connecting tube, a limiting ring and a perforated handle are provided on the outer side wall of the connecting tube, a medical tape is connected in series on the perforated handle, and a puncture head is provided on the end of the connecting tube away from the infusion tube. The disconnecting check hose includes a soft plastic tube with a slotted conical membrane inside one end. The puncture head is inserted into the soft plastic tube containing the slotted conical membrane, and the puncture head presses the slotted conical membrane against the inner wall of the soft plastic tube.

[0006] In a preferred embodiment, the injection tube includes an infusion tube with a snap-fit ​​ball at one end, one end of the infusion tube with the snap-fit ​​ball being inserted into a connecting tube, and an anti-dislodgement ring is provided at one end of the infusion tube with the snap-fit ​​ball.

[0007] In a preferred embodiment, the needle mechanism includes a connector with one end inserted into the interior of a soft plastic tube, the soft plastic tube and the connector being sealed and bonded together, a perforated handle 2 being provided on the outer side wall of the connector, a medical tape 4 being connected in series on the perforated handle 2, and a metal needle being sealed and fixedly connected to the end of the connector away from the soft plastic tube.

[0008] In a preferred embodiment, the locking mechanism includes a connecting ring with six threaded inclined plates on one side, a fastening nut being threaded onto the threaded inclined plates, and the six threaded inclined plates being sleeved on a snap-fit ​​convex ball.

[0009] In a preferred embodiment, the base mechanism includes a base plate fixedly connected to the connecting ring, a support is provided on the base plate, the support is fitted with the connecting pipe, the limiting ring and the anti-detachment ring, and a silicone pad is provided on the side of the base plate away from the support.

[0010] In one preferred embodiment, both the soft plastic tube and the metal needle are wrapped in medical gauze on the forearm of the non-human primate experimental subject.

[0011] In a preferred embodiment, both medical tape three and medical tape four are wound and bonded to the forearm of the non-human primate experimental subject.

[0012] In one preferred embodiment, the medical tape is placed on the base plate corresponding to the threaded inclined plate and adhered to the forearm of the non-human primate experimental subject.

[0013] In a preferred embodiment, the second medical tape is placed on the support corresponding to the connecting tube and adhered to the forearm of the non-human primate experimental subject.

[0014] Compared with the prior art, the advantages and positive effects of the present invention are as follows: This invention achieves a comfortable and stable fit between the invention and the experimental subject's forearm through the cooperation of the base mechanism, medical tape one, medical tape two, and silicone pad, effectively resisting the pulling caused by animal activity. Furthermore, the rigid locking of the injection tube's convex ball by the threaded inclined plate and fastening nut of the locking mechanism further ensures the reliability of the connection between the infusion tube and the intermediate connecting tube. The engagement of the limiting ring of the intermediate connecting tube with the support and the auxiliary fixation of medical tape three on the perforated handle one enhance the overall anti-torsion and anti-tilting capabilities, further improving the overall reliability of the invention during use.

[0015] This invention achieves safe detachment and immediate physical anti-backflow in case of accidental traction by using a separable one-way valve composed of the puncture head and the slit conical membrane in the detachable anti-backflow tubing. This prevents blood backflow and air ingress. Furthermore, the sealing of the needle mechanism connector with the soft plastic tube, the anchoring of the perforated handle with medical tape, and the gauze wrapping of the metal needle further reduce the risk of needle displacement within the blood vessel and protect the puncture area. Attached Figure Description

[0016] Figure 1 A perspective view of a puncture device for pharmaceutical injection testing is provided for the present invention; Figure 2 A partial cross-sectional perspective view of a puncture device for pharmaceutical injection testing is provided for this invention. Figure 3 This invention provides a perspective view of the locking mechanism and injection tube of a puncture device for pharmaceutical injection testing. Figure 4 This invention provides a perspective view of the connection between the injection tube and the intermediate tube of a puncture device for pharmaceutical injection testing. Figure 5 A perspective view of the intermediate connecting tube of a puncture device for pharmaceutical injection testing is provided for the present invention. Figure 6 A perspective view of a puncture device for pharmaceutical injection testing detached from the check tube, as presented in this invention. Figure 7 This invention provides a perspective view of the needle mechanism of a puncture device for pharmaceutical injection testing.

[0017] Legend: 1. Base mechanism; 2. Medical tape one; 3. Medical tape two; 4. Locking mechanism; 5. Injection tube; 6. Intermediate connecting tube; 7. Disengagement check tube; 8. Needle mechanism; 11. Base plate; 12. Support; 13. Silicone pad; 41. Connecting ring; 42. Threaded bevel plate; 43. Fastening nut; 51. Infusion tubing; 52. Snap-fit ​​ball; 53. Anti-detachment ring; 61. Connecting tube; 62. Limiting ring; 63. Hole handle one; 64. Puncture head; 65. Medical tape three; 71. Flexible plastic tubing; 72. Seamed conical membrane; 81. Connector; 82. Two-hole handle; 83. Four-piece medical tape; 84. Metal needle. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] Example 1

[0020] like Figure 1-2 As shown, the present invention provides a technical solution: a puncture device for pharmaceutical injection experiments, comprising a base mechanism 1 serving as the mounting base of the entire device. The base mechanism 1 is fixed to the forearm of a non-human primate experimental subject by medical tape 1 2 and medical tape 2 3, effectively resisting the pulling caused by animal activity and providing a basis for long-term placement. The base mechanism 1 is fixed with an injection tube 5, which serves as an external drug delivery channel, by a locking mechanism 4. The part of the injection tube 5 connected by the locking mechanism 4 is rigidly locked to the animal body, which can prevent the injection tube 5 from shaking or rotating during infusion, ensuring the stability of the interface. An intermediate connecting tube is installed on one end of the injection tube 5. 6. A disconnectable check tube 7 is inserted into the end of the intermediate connector 6 away from the injection tube 5. The intermediate connector 6 serves as a bridge between the injection tube 5 and the indwelling part in the body. The intermediate connector 6 and the disconnectable check tube 7 are connected by a plug-in method, so that the external injection tube 5 can be separated from the disconnectable check tube 7 when needed. When the test subject pulls the base mechanism 1 along with the intermediate connector 6 off, the intermediate connector 6 can be promptly separated from the disconnectable check tube 7, and blood can flow out by utilizing the check-back structure of the disconnectable check tube 7 itself. A needle mechanism 8 is fixedly installed on the end of the disconnectable check tube 7 away from the intermediate connector 6. The needle mechanism 8 is fixed at the end and directly inserted into the vein.

[0021] In this embodiment, a rigid platform is constructed by the base mechanism 1 and the locking mechanism 4 to be firmly connected to the forearm of the experimental subject. The detachable plug-in design between the intermediate tube 6 and the release check hose 7 is used to realize a dual guarantee mechanism that combines the stability of daily operation and the safety of emergency. The base mechanism 1 is attached to the skin via medical tape 1 2 and medical tape 2 3, forming a primary stabilizing layer that resists lateral pulling; and the injection tube 5 is rigidly fixed to the base mechanism 1 by the locking mechanism 4, ensuring that the injection tube 5 and its connected intermediate tube 6 will not shake or rotate relative to the animal body during routine infusion, thereby maintaining the stability of the access and reducing the risk of the needle mechanism 8 shifting due to friction or pulling. Furthermore, by utilizing the connection between the intermediate tube 6 and the disconnection check tube 7, a pre-set mechanical weak point or separation interface is constructed. When the experimental subject struggles or scratches violently, causing the base mechanism 1 to be forcefully pulled off, this design allows the intermediate tube 6, along with its external components such as the injection tube 5, to detach from the disconnection check tube 7 in a timely manner. This avoids directly transmitting the force to the needle mechanism 8 implanted in the blood vessel and its connected tubing, greatly reducing the risk of blood vessel tearing, severe bleeding, or tissue damage. After detachment, the disconnection check tube 7 itself has a check structure that can automatically seal the tube opening, preventing blood from continuously flowing out through the needle mechanism 8, thus achieving damage control.

[0022] Example 2

[0023] like Figure 1-7 As shown, the injection tube 5 includes an infusion tube 51 with a snap-fit ​​protrusion 52 at one end. One end of the infusion tube 51 with the snap-fit ​​protrusion 52 is inserted into the connecting tube 61. An anti-detachment ring 53 is provided at one end of the infusion tube 51 with the snap-fit ​​protrusion 52. This design forms a composite anti-detachment mechanism through the snap-fit ​​protrusion 52 and the anti-detachment ring 53 at the end of the infusion tube 51, ensuring that the injection tube 5 and the connecting tube 61 of the intermediate tube 6 can be flexibly connected and have extremely high anti-detachment stability. Furthermore, the intermediate connecting pipe 6 includes a connecting pipe 61. A limiting ring 62 and a perforated handle 63 are provided on the outer wall of the connecting pipe 61. Medical tape 65 is connected in series on the perforated handle 63. The medical tape 65 is wound and adhered to the forearm of the non-human primate experimental subject. A puncture head 64 is provided at the end of the connecting pipe 61 away from the infusion tube 51. In this design, the connecting pipe 61 serves as a multi-functional integrated interface, providing engagement and axial positioning with the base mechanism 1 through the limiting ring 62, preventing the connecting pipe 61 from shifting or sinking during use, and ensuring fluid flow. The alignment and stability of the channel; the perforated handle 63 on the outside of the connecting tube 61 and the medical tape 65 connected in series together form an auxiliary fixing point, which allows the user to wrap the perforated handle 63 around the forearm of the test subject by using the medical tape 65, thereby providing an additional flexible restraint for the entire intermediate tube 6, independent of the base mechanism 1, effectively dispersing external stress and preventing the connecting tube 61 from rotating or tilting due to accidental pulling; the puncture head 64 located at the distal end of the connecting tube 61 is the core of realizing the separable connection and anti-reverse function; Simultaneously, the disconnecting check hose 7 includes a soft plastic tube 71 with a slit conical membrane 72 inside one end. The soft plastic tube 71 is wrapped around the forearm of the non-human primate experimental subject with medical gauze. The puncture head 64 is inserted into the soft plastic tube 71 containing the slit conical membrane 72, and the puncture head 64 presses the slit conical membrane 72 against the inner wall of the soft plastic tube 71. In this design, the slit conical membrane 72 inside the soft plastic tube 71 and the puncture head 64 constitute a passive one-way valve mechanism; when the puncture head 64 is inserted and presses the slit conical membrane 72 to make it adhere tightly to the inner wall of the soft plastic tube 71, the puncture head 64 presses the slit conical membrane 72 against the inner wall of the soft plastic tube 71. When the soft plastic tube 71 is inserted into the inner wall, the slits on the conical membrane are forcibly opened, thus forming a fluid channel from the middle tube 6 to the needle mechanism 8, allowing the drug solution to pass through normally; once the puncture head 64 is pulled out due to operation needs or accidental force, the squeezing force applied to the slit conical membrane 72 disappears, and the elasticity and conical structure of the slit conical membrane 72 itself will cause the slits to close automatically, blocking the tube. This physical anti-reverse effect can immediately prevent blood from flowing back through the needle mechanism 8 or air from entering the blood vessels, effectively avoiding the resulting dose error, sample contamination or air embolism risk; Furthermore, the needle mechanism 8 includes a connector 81, one end of which is inserted into the soft plastic tube 71. The soft plastic tube 71 and the connector 81 are sealed together. The outer wall of the connector 81 is provided with a perforated handle 82, and medical tape 83 is connected in series on the perforated handle 82. The medical tape 83 is wrapped and bonded to the forearm of the non-human primate experimental subject. A metal needle 84 is sealed and fixedly connected to the end of the connector 81 away from the soft plastic tube 71. The metal needle 84 is wrapped with medical gauze on the forearm of the non-human primate experimental subject. In this design, the sealed bonding between the connector 81 and the soft plastic tube 71 ensures complete sealing from the tubing to the needle tip, eliminating the risk of leakage of the drug solution at the interface. The perforated handle 82 and the connected medical tape 83 are also sealed together. The fourth anchor point (483) forms an independent fixed anchor point. When the medical tape (483) is wrapped and fixed to the forearm of the test subject, it can disperse part of the pulling force acting on the soft plastic tube 71 or the metal needle 84 to this anchor point, thereby effectively buffering and preventing the metal needle 84 from shifting laterally in the blood vessel or piercing the blood vessel wall. At the same time, the sealed and fixed connection between the metal needle 84 and the connector 81 ensures the accuracy and reliability of the puncture. Moreover, the front end treatment method of wrapping the metal needle 84 and the soft plastic tube 71 together with medical gauze provides a soft protective layer for the puncture area. This not only prevents the test subject from directly biting or scratching the hard metal needle 84, but also absorbs sweat, reduces skin irritation, and improves the overall comfort and stability of the fixation package.

[0024] In this embodiment, a multi-level stable and safe intravenous access system is constructed through the coordinated design of the injection tube 5, intermediate tube 6, disconnection check tube 7 and needle mechanism 8. Among them, the infusion tube 51 of the injection tube 5 forms a firm and flexible insertion with the connecting tube 61 of the intermediate tube 6 through the snap-fit ​​ball 52 at its end and the anti-detachment ring 53, which ensures the anti-pull-out stability of the external infusion pipeline connection. Furthermore, the connecting tube 61 of the intermediate tube 6 achieves precise positioning with the base mechanism through the limiting ring 62, while the medical tape 65 with its perforated handle 63 connected in series and wrapped around the forearm of the experimental subject provides an independent flexible restraint for the intermediate tube 6, effectively dispersing stress and preventing torsion. Moreover, the puncture head 64 at the distal end of the connecting tube 61 is inserted into the soft plastic tube 71 that has been detached from the check tube 7, and forms a smooth infusion path by squeezing the slit conical membrane 72. When the puncture head 64 is accidentally pulled out, the automatic closure of the slit conical membrane 72 can immediately prevent blood backflow or air from entering. Meanwhile, the connector 81 of the needle mechanism 8 is sealed and bonded to the soft plastic tube 71, and is fixed on the forearm by the medical tape 83 on its perforated handle 82, providing a direct anchoring point for the metal needle 84, which significantly reduces the risk of needle displacement in the blood vessel. The treatment of wrapping the metal needle 84 and the adjacent soft plastic tube 71 together with medical gauze physically constitutes a flexible buffer protective layer that resists biting and friction.

[0025] Example 3

[0026] like Figure 1-5 As shown, the base mechanism 1 includes a base plate 11 fixedly connected to the connecting ring 41. Medical tape 1 2 is set on the base plate 11 corresponding to the threaded inclined plate 42 and is bonded to the forearm of the non-human primate experimental body. A support 12 is provided on the base plate 11. The support 12 is fitted with the connecting tube 61, the limiting ring 62 and the anti-detachment ring 53. Medical tape 2 3 is set on the support 12 corresponding to the connecting tube 61 and is bonded to the forearm of the non-human primate experimental body. A silicone pad 13 is provided on the side of the base plate 11 away from the support 12. Furthermore, the locking mechanism 4 includes a connecting ring 41 with six threaded inclined plates 42 on one side. A fastening nut 43 is threaded onto each threaded inclined plate 42. The six threaded inclined plates 42 are fitted onto the snap-fit ​​ball 52. In this design, the six threaded inclined plates 42 arranged around the connecting ring 41 together form a retractable mechanical clamp. When the threaded inclined plates 42 are fitted onto the snap-fit ​​ball 52 of the injection tube 5, tightening the fastening nut 43 threaded onto them forces all the threaded inclined plates 42 to converge synchronously and evenly towards the center using the helical propulsion of the threads. This applies a precise and all-around radial locking force to the spherical snap-fit ​​ball 52. This design achieves rigid gripping, transforming the insertion connection between the infusion tubing 51 of the injection tube 5 and the connecting tube 61 of the intermediate tube 6 from a potentially loose passive engagement state to a secure active mechanical locking state. This locking method can effectively resist the multi-directional violent pulling and twisting caused by the activities of non-human primate experimental subjects, ensuring that the infusion tubing 51 will not accidentally come out of the connecting tube 61 under any circumstances, thus guaranteeing the absolute continuity and sealing of the infusion passage. At the same time, this design allows users to easily tighten and loosen the tubing by adjusting the fastening nut 43, providing great operational flexibility for tubing replacement or maintenance during the experiment.

[0027] In this embodiment, the base mechanism 1 is fixedly connected to the connecting ring 41 via the base plate 11, forming a stable whole. The medical tape 1 2 on the base plate 11 and the medical tape 2 3 on the support 12 are bonded to the forearm of the experimental subject in a rear-to-rear arrangement, distributing the tension on the base mechanism 1 to two different anchor areas, which greatly enhances the overall stability against animal skin slippage or device tilting. Furthermore, the fitting of the support 12 on the base plate 11 with the connecting tube 61, the limiting ring 62, and the anti-detachment ring 53 restricts the freedom of the intermediate tube 6 and the end of the injection tube 5 from the bottom and sides, ensuring precise alignment and wobbling-free support of the fluid channel. The silicone pad 13 on the bottom surface of the base plate 11 improves the comfort of the fit and static friction.

[0028] Meanwhile, after the six threaded inclined plates 42 of the locking mechanism 4 fit around the snap-fit ​​ball 52 of the injection tube 5, they generate a uniform radial contraction force by tightening the fastening nut 43, thereby firmly locking the ball head, which can transform the insertion of the injection tube 5 and the intermediate connecting pipe 6 into a rigid connection that cannot be loosened.

[0029] Working principle: like Figure 1-7As shown, in use, the present invention first seals the connector 81, which has been inserted into the vein, with the soft plastic tube 71. The metal needle 84 and the adjacent portion of the soft plastic tube 71 are then wrapped and fixed to the forearm of the test subject using medical gauze. Simultaneously, the medical tape 83, connected to the perforated handle 82 on the connector 81, is wrapped and adhered to the forearm skin to establish a stable subcutaneous puncture site. Then, the silicone pad 13 is attached to the appropriate position on the forearm, aligning and fitting the support 12 with and locking the connecting tube 61, the limiting ring 62, and the anti-dislodgement ring 53 on the injection tube 5 infusion tube 51, which have been pre-connected to the soft plastic tube 71. At this point, the puncture head 64 at the distal end of the connecting tube 61 has been inserted into the soft plastic tube. The plastic tube 71 is opened and the slit conical membrane 72 is opened to form a passage. Then, medical tape 1 2 and medical tape 2 3 are used to stick the area of ​​the base plate 11 corresponding to the threaded inclined plate 42 and the area of ​​the support 12 to the forearm respectively, thus completing the base fixation of the entire device. Then, the snap-fit ​​ball 52 at the end of the infusion tube 51 is inserted into the connecting tube 61, and the six threaded inclined plates 42 on the connecting ring 41 are fitted with the snap-fit ​​ball 52. The fastening nut 43 is tightened to force the threaded inclined plates 42 to shrink evenly, thereby rigidly locking the infusion tube 51 and the connecting tube 61 together. Finally, the medical tape 3 65 connected in series on the perforated handle 1 63 of the intermediate connecting tube 6 is wrapped and glued to the forearm. At this point, the entire device is installed. After installation, the medication can be continuously and stably infused from the metal needle 84 through the injection tube 5, connecting tube 61, puncture head 64, the expanded slit conical membrane 72, the soft plastic tube 71, and the connector 81. If the experimental subject moves violently and the base mechanism 1 is pulled forcefully, the puncture head 64 can be disengaged from the soft plastic tube 71, and the slit conical membrane 72 will automatically close to prevent blood backflow. Loosening the fastening nut 43 will easily release the lock and allow for the replacement of the injection tube 5 and other components.

[0030] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments that can be applied to other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the protection scope of the present invention.

Claims

1. A puncture device for pharmaceutical injection testing, characterized in that: The device includes a base mechanism (1), which is fixed to the forearm of a non-human primate experimental body by medical tape one (2) and medical tape two (3). The base mechanism (1) is fixed with an injection tube (5) by a locking mechanism (4). An intermediate tube (6) is installed on one end of the injection tube (5). A release check tube (7) is inserted into the end of the intermediate tube (6) away from the injection tube (5). A needle mechanism (8) is fixedly installed on the end of the release check tube (7) away from the intermediate tube (6). The intermediate tube (6) includes a connecting tube (61), a limiting ring (62) and a perforated handle (63) are provided on the outer side wall of the connecting tube (61), a medical tape (65) is connected in series on the perforated handle (63), and a puncture head (64) is provided on the end of the connecting tube (61) away from the infusion tube (51). The disconnecting check hose (7) includes a soft plastic tube (71) with a slotted conical membrane (72) inside one end. The puncture head (64) is inserted into the soft plastic tube (71) where the slotted conical membrane (72) is located, and the puncture head (64) squeezes the slotted conical membrane (72) onto the inner wall of the soft plastic tube (71).

2. The puncture device for pharmaceutical injection testing according to claim 1, characterized in that: The injection tube (5) includes an infusion tube (51) with a snap-fit ​​ball (52) at one end. One end of the infusion tube (51) with the snap-fit ​​ball (52) is inserted into the connecting tube (61). An anti-dislodgement ring (53) is provided at one end of the infusion tube (51) with the snap-fit ​​ball (52).

3. The puncture device for pharmaceutical injection testing according to claim 1, characterized in that: The needle mechanism (8) includes a connector (81) with one end inserted into the soft plastic tube (71). The soft plastic tube (71) and the connector (81) are sealed and bonded together. A perforated handle (82) is provided on the outer side wall of the connector (81). A medical tape (83) is connected in series on the perforated handle (82). A metal needle (84) is sealed and fixedly connected to the end of the connector (81) away from the soft plastic tube (71).

4. The puncture device for pharmaceutical injection testing according to claim 1, characterized in that: The locking mechanism (4) includes a connecting ring (41) with six threaded inclined plates (42) on one side. A fastening nut (43) is threaded onto the threaded inclined plates (42), and the six threaded inclined plates (42) are fitted onto the snap-fit ​​convex ball (52).

5. A puncture device for pharmaceutical injection testing according to claim 1, characterized in that: The base mechanism (1) includes a base plate (11) fixedly connected to a connecting ring (41). A support (12) is provided on the base plate (11). The support (12) is fitted with a connecting pipe (61), a limiting ring (62) and an anti-detachment ring (53). A silicone pad (13) is provided on the side of the base plate (11) away from the support (12).

6. The puncture device for pharmaceutical injection testing according to claim 1, characterized in that: The soft plastic tube (71) and the metal needle (84) were both wrapped in medical gauze on the forearm of the non-human primate experimental subject.

7. The puncture device for pharmaceutical injection testing according to claim 1, characterized in that: Both medical tape three (65) and medical tape four (83) were wrapped and adhered to the forearm of the non-human primate experimental subject.

8. The puncture device for pharmaceutical injection testing according to claim 1, characterized in that: The medical tape (2) is placed on the base plate (11) corresponding to the threaded inclined plate (42) and is attached to the forearm of the non-human primate experimental body.

9. A puncture device for pharmaceutical injection testing according to claim 1, characterized in that: The medical tape 2 (3) is placed on the support (12) corresponding to the connecting tube (61) and is attached to the forearm of the non-human primate experimental body.

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