53 results about "Choroid membrane" patented technology

The invention belongs to the technical field of nano-drugs, and discloses a multifunctional nano-drug delivery system for treating neovascular eye diseases and a preparation method of the multifunctional nano-drug delivery system. The nano drug delivery system disclosed by the invention is a composite nano preparation which takes dendritic mesoporous silica nanoparticles as a carrier and co-loads cerium zirconium oxide nano enzyme and an anti-VEGF (vascular endothelial growth factor) drug, various active oxygen can be efficiently removed, oxygen is continuously released through catalytic decomposition of hydrogen peroxide, a retina hypoxia microenvironment is improved, and the retina hypoxia effect is improved. According to the present invention, the anti-VEGF drug delivery system can reduce the oxidative stress induced retinal pigment epithelial cell apoptosis rate, reduce the inflammatory reaction, and simultaneously achieve the slow release and the controlled release of the anti-VEGF drug, and the drug effect maintenance time can achieve more than 60 days, such that the multi-target synergistic treatment can be achieved through the synergistic regulation of the multiple pathological links such as oxygen deficit-oxidative stress-inflammation-angiogenesis, and the anti-VEGF drug delivery effect can be achieved. The choroidal neovascularization can be effectively inhibited by single intravitreal injection, and a new strategy of multi-target collaborative treatment is provided for neovascular macular degeneration and other eye diseases.

An image processing method performed by a processor includes: a step of acquiring a fundus image in which choroid blood vessels are visualized; a step of extracting choroid arteries in the fundus image acquired in the acquiring step by performing image processing on the fundus image; and a step of generating a fundus image in which the choroid arteries extracted in the extracting step are highlighted.

The present invention relates to an apparatus (110) and a method (210) configured to determine a choroidal topography (218) on a region (114, 114') of the retina (116) of a human eye (117), and to the use of the apparatus (110) for determining the effect of at least one ophthalmic lens design on the choroidal topography (218). In this document, the device (110) includes: - at least two separate displays (122, 122'), each configured to provide retinal stimulation (112, 112'), thereby providing two independent retinal stimuli (112, 112'); - at least two optical transmission elements, including a first optical transmission element and a second optical transmission element, each configured to project at least one of the retinal stimulation (112, 112') or a phase map onto a region of the retina of a human eye, wherein the phase map includes a modified retinal stimulation; - a measuring device (142) for capturing a human eye by using reflected light received from a region (114, 114') on the retina (116) of the human eye (117). (117) Choroidal topography (218) on region (114, 114') of retina (116); - Optical filter (152) configured to separate reflected light received from region (114, 114') of retina (116) of human eye (117) from phase map of region (114, 114') of retina (116) of human eye (117), wherein the second optical transmission element is further configured to simultaneously project each of the at least two separate phase maps at different retinal eccentricities onto each of at least two separate regions (134, 134') of retina (116) of human eye (117), wherein these separate regions (134, 134') include peripheral region and foveal region of retina (116) of human eye (117).

This invention provides a method and device for refractive development assessment based on visual development prediction neural circuits, relating to the field of myopia management technology. The method includes: acquiring color retinal optical imaging signals and refractive ground state quantification values ​​of the subject; performing retinal stabilization preprocessing; extracting multi-level morphological features through a reentrant layered retinal choroid encoder; performing spatial feature aggregation gating on the extracted feature maps to obtain feature vectors; concatenating and integrating the feature vectors with the refractive ground state quantification values ​​to obtain fused feature vectors; constructing a fused feature vector sequence and inputting it into a refractive development dynamics internal model inferrer to generate a future multi-time-point refractive state prediction sequence; converting it into an interpretable refractive state numerical sequence; and providing risk warnings based on preset risk thresholds. This invention explicitly embeds physiological mechanisms prior into the model structure and parameter adaptive strategies, thereby maintaining the stability and interpretability of predictions even in a single medical visit scenario.

The invention belongs to the technical field of biological medicines, and relates to application of an FGF2 inhibitor in preparation of a medicine for treating retina and choroidal neovascular diseases. An oxygen-induced retinopathy (OIR) mouse model and a novel small molecule compound are used for researching related mechanisms in retinopathy neovascularization, and the treatment effect of the small molecule compound is evaluated. Results show that the Refi-10 disclosed by the invention can be used for treating vascular retinopathy by inhibiting FGF2 targets, and a replacement or supplement method of VEGF (vascular endothelial growth factor) inhibiting drugs is provided.

A System / Method / Device for segmenting the choroid-scleral layer from an optical coherent tomography (OCT) volume scan. The present system uses a deep learning machine model based on a neural network that include multiple convolution layers, but no deconvolution layers. Rather, the present neural network is based on a novel architecture based on the discrete cosine transform.

The present invention addresses the problem of providing an inhibitor for retinochoroidal disorders, in particular, an inhibitor for retinochoroidal scar formation and retinochoroidal atrophy in an epiretinal, intraretinal or subretinal tissue. This problem can be solved by preparing an inhibitor for retinochoroidal disorders which comprises, as an active ingredient, (E)-4-(2-{3-[(1H-pyrazol-1-yl)methyl]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-yl}vinyl)benzoic acid, an ester thereof or a salt of the same. The inhibitor for retinochoroidal disorders can inhibit collagen atrophy of retinal pigment epithelium cells, fibroblasts, glial cells and the like and thus inhibit retinochoroidal disorders.

To enable understanding of choroidal asymmetry. [Solution] In choroidal vascular images, the direction of blood vessel course is determined for each of several pairs of analysis points that are symmetrical with respect to the line connecting the macula and the optic nerve head. The asymmetry of each pair of analysis points is analyzed from the direction of blood vessel course of each analysis point, and the pair of analysis points with asymmetry is highlighted by enclosing them in a frame.

This image processing device executes processing that includes: acquiring a tomographic image in the depth direction including choroidal blood vessels and sclera; executing emphasis processing that emphasizes a physical quantity indicating a brightness change in the depth direction in the tomographic image with respect to a partial region of the tomographic image; deriving an image feature amount pertaining to the brightness change in the depth direction in the emphasized region; and determining, on the basis of the image feature amount, a site on the tomographic image in which the image feature amount exceeds a predetermined threshold as a boundary between the choroidal blood vessels and the sclera.

The application discloses a choroid layer and choroid blood vessel segmentation method, system and device, and relates to the technical field of image processing. The method comprises the following steps: acquiring a target OCT choroid image; preprocessing the target OCT choroid image to generate a target choroid dataset; inputting the target choroid dataset into a pre-trained ASPP-SE-U-Net network for prediction; the ASPP-SE-U-Net network comprises a choroid CNN model and a choroid blood vessel CNN model; the step of inputting the target choroid dataset into the pre-trained ASPP-SE-U-Net network for prediction comprises the following steps: generating a choroid segmentation prediction map according to the choroid CNN model, generating a choroid blood vessel segmentation prediction map according to the choroid blood vessel CNN model and the choroid segmentation prediction map, superimposing the choroid segmentation prediction map and the choroid blood vessel segmentation prediction map to generate a choroid layer and choroid blood vessel segmentation map. According to the application, the segmentation result is more accurate.

The present disclosure provides for one or more embodiments for treating retinal degenerative disorders in a subject by administering to the subject an effective amount of allogeneic mesenchymal stem cells to the subject's suprachoroidal area. Allogeneic mesenchymal stem cells, when used in the disclosed treatment regimen, may exhibit anti-inflammatory, immunomodulatory, anti-fibrotic, pro-vascular, and / or pro-regenerative processes. Thus, allogeneic mesenchymal stem cells may be understood to have the potential to target and treat multiple pathological targets implicated in retinal degenerative disorders, including retinal disorders characterized by drusen accumulation, some of which have inherited forms.

To provide an image processing method for analyzing choroidal blood vessels.SOLUTION: The method includes a step of acquiring an OCT image of a subject's eye by optical coherence tomography (OCT), a step of extracting a region other than a structure of the subject's eye in the OCT image, and a step of generating a first display screen in which position information on a scan position for acquiring the OCT image is superimposed on the region.SELECTED DRAWING: Figure 10

The present invention relates to a method of producing a population of activated innate lymphoid cells, the population of activated innate lymphoid cells obtainable thereby, and use thereof in preventing or treating a disease in a subject. The present invention finds particular utility in the production of activated innate lymphoid cells useful in the treatment of ocular diseases such as neovascular diseases of the choroid and / or the retina.

The invention discloses an atropine derivative and a preparation method and application thereof, and belongs to the technical field of medical preparations, the atropine derivative and a salt or a pharmaceutical composition thereof can be used as a ciliary muscle paralysis agent and / or a mydriasis agent; the choroid and sclera functions can be regulated and controlled by improving choroid microcirculation and sclera hypoxia environment, inhibiting an HIF-1alpha signal channel and directly targeting sclera fibroblasts to inhibit extracellular matrix generation and remodeling; the medicine is used for relieving muscae volitantes symptoms; amblyopia, lazy eye diseases or myopia can be relieved; for treating or preventing myopia; the traditional Chinese medicine composition has good maintenance time and treatment effect, can obviously reduce the use frequency and use amount, improves the use experience, and reduces the medicine use cost.

The application discloses a kidney function risk information processing method based on OCTA features and clinical data, and relates to the technical field of artificial intelligence and intelligent medical treatment. Quantitative features such as blood vessel density, perfusion area, retinal thickness and choroidal vascular volume are extracted from multi-scale fundus OCTA images of a subject, and total feature data sets are constructed in combination with clinical biochemical indexes, so as to estimate glomerular filtration rate as an outcome index for binary classification labeling. Elastic network regression is adopted to screen key modeling features, and various machine learning models such as logistic regression, random forest and gradient boosting are simultaneously trained on a training set. After 5-fold cross-validation optimization, the optimal model is selected by comprehensively considering the receiver operating characteristic curve, the calibration curve and the decision curve. A nomogram is constructed based on the optimal model, and individual early kidney function decline risk probability numerical values and auxiliary reference information of the subject are outputted for reference of clinical doctors.

The present invention relates to the use of anti-hemichannel compounds, including anti-connexin 43 hemichannel opening compounds, in rescuing or restoring retinal function, rescuing or restoring retinal structure, and / or rescuing or restoring choroidal structure and / or function in chronic retinal disorders and other disorders.

The invention relates to the technical field of medicines, and particularly discloses a traditional Chinese medicine composition for preventing and improving myopia and asthenopia of teenagers and application of the traditional Chinese medicine composition. The composition is prepared from nine medicinal materials including rhizoma gastrodiae, radix puerariae, semen cassiae, fructus lycii, semen sesami nigrum, mulberry, folium mori, mint and rhizoma imperatae, and a unique tonifying-clearing-rising three-dimensional treatment network is constructed on the basis of the compatibility concept of invigorating yang and dredging collaterals and applying clearing and tonifying at the same time. The composition can be prepared into various oral preparations such as granules, tablets, capsules, oral liquid and the like, and is suitable for preventing and treating juvenile myopia, pseudomyopia, asthenopia, eye dryness and blurred vision. Animal and clinical researches prove that the composition can effectively inhibit ocular axis growth, improve choroidal blood flow and relieve asthenopia, and has the advantages of being safe to take and suitable for long-term conditioning of teenagers.

To provide an image for supporting diagnosis of a fundus by an ophthalmologist.SOLUTION: Provided is an image processing method including: a step (208) of analyzing a choroidal blood vessel image and estimating the position of a vortex vein; a step (212) of calculating a feature value indicating the positional relationship between the position of the vortex vein and the position of a specific portion of the fundus oculi; and a step of superimposing and displaying the feature value on the fundus oculi image.SELECTED DRAWING: Figure 5

This invention relates to a self-assembling polypeptide for regulating the permeability of retinal pigment epithelium (RPE), its preparation method, and its applications. The self-assembling polypeptide comprises an integrin receptor-targeting peptide, a self-assembling polypeptide, and a hydrophobic molecule sequentially linked. The self-assembling polypeptide designed in this invention can self-assemble into nanoparticles and specifically target RPE cells. After interacting with receptors on the cell membrane, the nanoparticles transform into nanofibers, achieving rapid targeted enrichment of RPE tissue. Furthermore, by regulating the permeability of RPE tissue, it can enhance the transcellular drug transport capacity, providing a new clinical application strategy for the treatment of macular neovascularization, especially polypoid choroidal vascular lesions.

A virtual reality head-mounted display device and a method for myopia control by stimulating small cell pathways are disclosed, relating to the fields of virtual reality (VR) technology and visual health intervention technology. The device includes: a display; a memory storing a computer program; and a processor coupled to the display and the memory for executing the computer program to control the display to present visual stimuli. The visual stimuli are configured to present dynamic patterns with first color-opposites characteristics within at least a portion of the visual field to selectively activate small cell pathways in the user's visual system. The intervention time of the dynamic patterns ranges from 3 to 30 minutes, and the time frequency ranges from 5 to 10 Hz. Through high spatial frequency (≥2 cpd) radial targets with red-green opposition, the device selectively stimulates retinal small cell ganglion cells and subsequent small cell visual nerve conduction pathways, significantly increasing the choroidal thickness near the fovea, thereby inhibiting myopia progression.

A method and system for detecting an advanced stage of age-related macular degeneration in a retina. Optical coherence tomography (OCT) imaging data for a retina is received. A presence of choroidal neovascularization (CNV) in the retina is detected, via a machine learning system, using the OCT imaging data. An output that indicates that the presence of CNV in the retina has been detected is generated.

The application discloses a dual-specific antibody with functions of inflammation microenvironment regulation and simultaneous inhibition of choroidal neovascularization, and a preparation method and application thereof. The dual-specific antibody is a single-chain antibody, comprises an IL1R, an IL-1 receptor complex auxiliary subunit IL-1RAcP fragment, and extracellular domains D2 (VEGFR2D2) and D3 (VEGFR2D3) of a tyrosine kinase transmembrane receptor VEGFR2, can simultaneously bind to IL-1 and VEGF, has functions of regulating an inflammation microenvironment and inhibiting choroidal neovascularization, and can more accurately treat fundus-related diseases represented by age-related macular degeneration.

It is desired to visualize blood vessels based on volume data of a subject's eye.SOLUTION: An image processing method performed by a processor includes acquiring an image depicting a choroid, performing enhancement processing to enhance contrast of the acquired image, performing binarization processing on the image subjected to the enhancement processing, and extracting a region corresponding to a choroidal blood vessel in the choroid from the image subjected to the binarization processing.SELECTED DRAWING: Figure 6

The application discloses application of TAPI-1 in preparation of a drug for treating dry age-related macular degeneration, and belongs to the technical field of biological medicine. A dry age-related macular degeneration mouse model is constructed by using sodium iodate, and a TAPI-1 solution is injected into the vitreous body for treatment, and structural examination and histopathological examination are conducted on the mouse. The experimental results show that, compared with the control group, the retinal choroid structure of the mouse treated by TAPI-1 is more complete, the fundus lesion area is less, the damage degree of the pigment epithelium and the photoreceptor cell is lighter, and the expression level of the inflammatory molecules in the ocular tissue is lower, and the treatment effect is significant. The application firstly proposes that TAPI-1 is used for preparing a drug for treating and / or preventing dry age-related macular degeneration, a new treatment strategy is provided for the dry age-related macular degeneration, and the application has a wide application prospect.

An apparatus and a method for determining a choroidal topography over a region on a retina of an eye of a person are disclosed. The apparatus is also used to determine an effect of an ophthalmic lens design on the choroidal topography. The apparatus includes two individual displays, two optical transfer elements, a measuring device, and an optical filter. The displays provide a retinal stimulus and the optical transfer elements projects the retinal stimulus or a phase map to a region on a retina. The phase map contains a modified retinal stimulus. The measuring device images a choroidal topography over the region on the retina by capturing reflected light. The optical filter separates the reflected light from the projected phase map. Further, the second optical transfer element simultaneously projects the individual phase maps at a different retinal eccentricity to a peripheral region and a foveal region of the retina.

This invention relates to the field of image data processing technology, specifically to an OCT-based image choroid segmentation system and method. The scheme performs discrete wavelet transform on the input image to separate low-frequency and high-frequency components; extracts low-frequency global context features and high-frequency boundary direction features through a dual-branch network; in the frequency domain cross-attention module, features are aligned using high-frequency boundary direction features as query keys and low-frequency global context features as keys and values ​​to suppress speckle noise interference and output fused features; the decoder receives the fused features and outputs a choroid segmentation mask. This invention solves the problem of the contradiction between speckle noise suppression and boundary preservation in existing spatial domain processing, filtering out noise while retaining weak high-frequency boundary information, thus improving the accuracy of choroid segmentation boundary localization.

A method includes illuminating a region of a choroid of an eye of a patient with off-axis illumination from a first imaging channel that is off-axis relative to an axis of focus of the eye. The method can also include capturing an image on the choroid with the off-axis illumination from the first imaging channel offset from an image sensor in the first imaging channel. A second off-axis illumination from a second imaging channel that is off-axis from the first imaging channel and the off-axis illumination can illuminate the same or a different region of the choroid. The captured image of the choroid can be provided to a machine learning system. An indicator associated with the image can be identified based on an output of the machine learning system.

The invention relates to a construction method and application of an animal model with retina geographic atrophy (GA) accompanied by choroidal neovascularization (CNV) symptoms. According to the method, sodium iodate is injected at multiple points in the subretinal space of cynomolgus monkeys, so that the retina has typical and clinically close retinopathy GA and CNV symptoms, and the blank of animal models for preclinical evaluation of multi-target drugs for treating GA and CNV at present is filled.

Dendrimer compositions and methods for treating one or more ocular inflammatory and / or angiogenic diseases and / or conditions, including hydroxyl-terminated dendrimers complexed or conjugated to one or more active agents for treating or reducing one or more symptoms of an ocular disease, and / or for diagnosing an ocular disease and / or condition. The dendrimers can include one or more ethylenediamine core poly(amidoamine) (PAMAM) hydroxyl-terminated generation 4, 5, 6, 7, 8, 9, or 10 dendrimers. The active agent can be a VEGFR tyrosine kinase inhibitor, including sunitinib or an analog thereof. Preferably, the compositions are suitable for administration via a systemic route to target activated microglia / macrophages in the retina / choroid.