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Application of puerarin gel eye drop in preparation of drugs for treating ischemic ocular fundus diseases

A technology for ischemic diseases, eye drops, applied in the field of traditional Chinese medicine

Active Publication Date: 2015-06-10
ZHEJIANG SHAPUAISI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] It is generally believed that the curative effect of eye drops is limited to the front of the eye disease, and it is believed that its local application, the concentration of the drug in the fundus is very small; usually the disease of the back of the eye needs repeated intravenous injection or direct intravitreous injection, on the other hand, kudzu root Suspension injections carry many risks

Method used

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  • Application of puerarin gel eye drop in preparation of drugs for treating ischemic ocular fundus diseases
  • Application of puerarin gel eye drop in preparation of drugs for treating ischemic ocular fundus diseases
  • Application of puerarin gel eye drop in preparation of drugs for treating ischemic ocular fundus diseases

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1. Preparation of Puerarin Gel Eye Drops

[0069] prescription:

[0070]

[0071]

[0072] Preparation method:

[0073] 1. Take a batching pot, weigh the prescription amount of poloxamer 407, put it in a 100°C oven for disinfection, take it out and seal it after 5 minutes;

[0074] 2. Cool to room temperature with 1000g of freshly boiled water for injection;

[0075] 3. Take another batching pot, weigh the buffered p-sodium citrate citric acid, add the above-mentioned 700g water for injection, and get a solution with a pH of 6.1--6.3 as 1 solution;

[0076] 4. Weigh the prescribed amount of sodium hyaluronate, sodium edetate, sodium metabisulfite, benzalkonium bromide, borneol, etc., and add them to liquid 1 one by one, stir and dissolve successively to form liquid 2.;

[0077] 5. Heat liquid 2 to 70-75°C, add puerarin in the prescribed amount immediately, stir well to disperse and dissolve and form a clear solution, and weigh liquid 3;

[0078] 6. ...

Embodiment 2

[0080] Embodiment 2. Preparation of Puerarin Gel Eye Drops

[0081] prescription:

[0082]

[0083] Preparation Process

[0084] 1. Cool to room temperature with 1000g of freshly boiled water for injection;

[0085] 2. Weigh sodium citrate and citric acid according to the prescription amount, add the above-mentioned water for injection into the batching pot, and get a pH of 6.1-6.4, which is 1 solution;

[0086] 3. Take 700g of 1 solution in another batching pot, add the prescription amount of Poloxamer 407, Poloxamer 188, stir to dissolve and disperse, and get a clear solution after standing for 2-3 hours, which is 2 solutions;

[0087] 4. Add sodium ethylenediamine tetraacetate, sodium metabisulfite, benzalkonium chloride, and borneol to 2 liquids according to the prescribed amount to make 3 liquids;

[0088] 5. Add puerarin according to the prescription amount and stir it into the 3 liquids one by one, stir it ultrasonically to make it fully dissolve and form a clear ...

Embodiment 3

[0089] Embodiment 3. The preparation of puerarin gel eye drops:

[0090] prescription:

[0091]

[0092]

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Abstract

The invention provides an application of puerarin gel eye drop in preparation of drugs for treating ischemic ocular fundus diseases. The eye drop is prepared from puerarin, EDTA, sodium metabisulfite, borneol, benzalkonium bromide, poloxamer 407, sodium hyaluronate, sodium citrate, citric acid and injection water, an HPLC-UV method is adopted, intraocular pharmacokinetics of rabbits proves that the absorbed doses of 1.2% puerarin gel eye drop in retina and choroid are respectively larger than 70% and 62% in common puerarin eye drop; converted according to specific gravity of aqueous fluid and vitreous body, intraocular puerarin contents satisfy the relation that choroid> retina>aqueous fluid > vitreous body, which indicates that an enough absorbed dose of the puerarin can reach ocular fundus. Observation finds that average drug contents (ng / g) of the 1.2% puerarin gel eye drop on time points of a 1-6 hour puerarin time-concentration curve of rabbit retina and choroid are not lower than contents (ng / g) measured when rabbits effectively induce reinforced ocular fundus blood flow velocity in retina hemodynamics measurement, so that the fact that the puerarin gel eye drop can be used as intravenous puerarin for treating ischemic ocular fundus diseases can be proved.

Description

1. Technical field: [0001] The invention relates to the technological advancement of traditional Chinese medicine, in particular to the application of puerarin gel eye drops in the preparation of medicines for treating fundus ischemic diseases. Two. Background technology: [0002] Pueraria lobata is the root of the perennial deciduous vine of the leguminous family Pueraria, which returns to the spleen and stomach meridians, and has the functions of promoting yang, promoting blood circulation, and dredging collaterals. "Compendium of Materia Medica" records that kudzu root is sweet and pungent, flat in nature, non-toxic, and has the functions of detoxifying and opening the skin. Puerarin is one of the active ingredients extracted from Pueraria lobata root. It is an isoflavone compound. Its English name is puerarin, PUE, so it is also called Pulerin. Puerarin is extracted from the dried root of the leguminous plant Puera.ria lobata (Willd.) Ohwi, chemical name: 8-β-D-glucopyr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/352A61P9/10A61P27/02
Inventor 张银娣朱延勤沈建平姚进李倩吴建伟胡正国陈德康
Owner ZHEJIANG SHAPUAISI PHARMA
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