34 results about "Electroretinography" patented technology

The invention discloses an EOG (Electrooculography)-based ERG (Electroretinography) signal acquisition and processing system and method. The system comprises a control unit, a retinal stimulator unit, an ERG signal acquisition unit and an ERG signal processing unit. The method comprises the following steps: adjusting illumination and flash rate of a stimulation light source; arranging three skin electrodes on the forehead just above eyes of a subject, on the inner sides of the eyes and the bridge of a nose and at eyelids respectively; performing dark adaptation for more than 20 minutes; aligning the eyes of the subject to the stimulation light source; acquiring an EOG signal; performing light stimulation on the eyes of the subject, synchronously acquiring the ERG signals on the inner sides of the eyes and the bridge of the nose and at the eyelids of the subject respectively, and storing after signal conditioning and AD (Analog-Digital) conversion; reading the ERG signals by an ERG signal processing and analysis unit and processing and analyzing the ERG signal. The ERG signals are acquired by using the external skin electrodes, so that the acquisition is more convenient and safer, and the cost is lower; for signal processing, the adopted method is small in operation and high in feasibility and can realize rapid signal processing.

Methods for the diagnosis, prognosis, patient stratification and prediction of pharmacological response in patients afflicted by psychiatric disorders based on electroretinography (ERG) parameters are described.

It is intended to provide a novel therapeutic method for a disease with apoptotic degeneration in eye tissue cells such as retinal pigment degeneration. Attention was paid on the concomitant administration of two neurotrophic factors: pigment epithelium-derived factor (PEDF) and fibroblast growth factor 2 (FGF2). The sites of actions are considered to be different between PEDF and FGF2. An SIV-PEDF vector and an SIV-FGF2 vector were constructed and administered to the subretinal space of an RCS rat, which is a disease model of retinal pigment degeneration, and their effects were evaluated. At 4 weeks, 8 weeks and 12 weeks after the administration of the vectors, a significantly higher visual cell protection effect was obtained in a group with concomitant administration than in a group with sole administration. Further, the functional evaluation of retina was carried out by electroretinogram and an effect in the group with concomitant administration was significantly higher than in the group with sole administration. From the above results, it was found for the first time that the concomitant administration of PEDF and FGF2 has higher effects in the treatment of retinal pigment degeneration than conventional methods.

The present invention relates to electroretinography (ERG) units and related methods of use. In particular, the present invention relates to electroretinography units used, for example, for evaluating the retinal function of a subject. The ERG unit of the present invention is portable and contains a compact flash card for flexible and automated ERG evaluation.

The invention provides a signal amplifier for a portable detection system of the electroretinogram (ERG). The signal amplifier comprises two gain adjusting knobs, a built-in signal amplification circuit, two measuring electrode magnetic interfaces, a reference electrode, as well as a common reference electrode interface, two measuring electrodes and two output plugs, wherein the two measuring electrode magnetic interfaces are arranged at the input end of the signal amplifier, the reference electrode is connected to the signal amplifier through one reference electrode magnetic interface, the main body part of the signal amplifier is J-shaped, the end, connected with the measuring electrodes, of the main body part of the signal amplifier is bent, due to the adoption of the novel design, the measuring accuracy and simplicity are greatly improved, and the cost is also extremely low.

The invention provides an active electrode detection device for an electroretinogram and an electro-oculogram. The device comprises a miniature front signal amplifier, a ground electrode, an ERG electrode, an EOG electrode and a reference electrode, the ground electrode, the ERG electrode, the EOG electrode and the reference electrode are connected with the miniature front signal amplifier, the reference electrode is arranged on one side of the miniature front signal amplifier, the ERG electrode and the EOG electrode use the same universal reference electrode, and the reference electrode is attached to the surface of human face skin. According to the device, a short connecting wire between a sensor and the amplifier is provided with a short transmission line, so that most external noise and interference can be eliminated; by means of the design, signals can have high signal-to-noise ratio, high reproducibility, high common-mode rejection ratio and high sensibility to low stimulation, and the electrodes can be made into disposable electrodes, so that infection is prevented, which is beneficial to patients and doctors, and infection control standards of a hospital are met.

Apparatus for evoking and sensing ophthalmic physiological signals in an eye, the apparatus comprising: an elongated tubular light pipe having a longitudinal axis, a distal end and a proximal end, the distal end terminating in a spheroid recess; an active electrode having a distal end and a proximal end, the active electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the active electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; and a reference electrode having a distal end and a proximal end, the reference electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the reference electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; wherein the distal end of the active electrode is located closer to the longitudinal axis of the elongated tubular light pipe than the distal end of the reference electrode.

A flexible loop electrode for electroretinographic (ERG) recordings of extra-corneal signals with a protective bead and a U-shaped electrode form that is particularly adapted for use with spectacles or a fixed mount. Means also employed to detect electrode integrity.

In some embodiments, a system for providing a therapeutic treatment to a patient's eye includes a treatment beam source configured to transmit a treatment beam along a treatment beam path. The system further includes a processor coupled to the treatment beam source, the processor being configured to direct the treatment beam onto retinal tissue of the patient's eye and deliver a series of short duration pulses from the treatment beam onto the retinal tissue at a first treatment spot to treat the retinal tissue. In some embodiments, a pre-treatment evaluation method using electroretinography (ERG) data may be used to predict effects of treatment beams at different power values and to determine optimal power values.

A method and device for non-invasive monitoring of the temperature of the retina and the retinal pigment epithelium inside the eye, particularly during heating of the bottom of the eye, wherein alternating probing short-duration pulses of light, one at wavelength close to the absorption maximum of the photoreceptor cell type and the other at wavelength in the near-infrared region, are directed at the retinal tissue at appropriate time intervals.Photoreceptor cell electrical signals, photoresponses, are recorded using electroretinography (ERG) and the changes in retinal temperature are determined from changes in photoresponse kinetics and changes in photoreceptor sensitivity to the stimuli. The method is especially applicable at temperatures up to 45° C. for humans and for other animals.

An ophthalmologic examination apparatus has a main unit housing an illuminating optical system that illuminates a fundus of a subject's eye to be examined and an imaging optical system that images the illuminated eye fundus. First and second attachment units are removably and exchangeably mounted to the main unit for providing different ophthalmologic functions. The first attachment unit houses an imaging device that captures an image of the eye fundus via the imaging optical system housed in the main unit. The second attachment unit houses a light source that emits stimulating light for an electroretinogram and which is projected onto the eye fundus via the imaging optical system housed in the main unit.

The invention provides a double-channel ERG (electroretinogram) portable detection system with a pre-amplifier. The system comprises a miniature signal preamplifier, a flash stimulator, a first group of detection electrodes and a second group of detection electrodes, the miniature signal preamplifier is provided with four magnetic joints, each group of detection electrodes include a cornea contact electrode and a ground electrode, a signal line of each cornea contact electrode and a connecting line of each ground electrode form a twisted pair, one end of each twisted pair is connected with the corresponding magnetic joint on the preamplifier through a permanent magnet, two adjustable gain knobs are arranged on the miniature signal preamplifier and used for amplifying signals, and detection signals are amplified and then displayed on a display device of a mobile terminal. The cornea contact electrodes and the ground electrodes are close to the preamplifier, the connecting lines are short, external signal interference is decreased, the twisted pairs offset mutual interference of two channels in detection, the system is small in total size and convenient to use, and an APP (application) of the handheld mobile terminal can conveniently select flash stimulation modes.

A method and apparatus for visual stimulation and recording of the pattern electroretinogram (PERG) and of the visual evoked potentials (VEP), by way of transient and steady-state visual stimuli, including a simultaneous transient and steady-state stimulation of a plurality of zones of the visual field visualization element, and an algorithm able to reconstruct the second harmonic component of the steady-state signal and the transient signal of the zones.

Apparatus for evoking and sensing ophthalmic physiological signals in an eye, the apparatus comprising: an elongated tubular light pipe having a longitudinal axis, a distal end and a proximal end, the distal end terminating in a spheroid recess; an active electrode having a distal end and a proximal end, the active electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the active electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; and a reference electrode having a distal end and a proximal end, the reference electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the reference electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; wherein the distal end of the active electrode is located closer to the longitudinal axis of the elongated tubular light pipe than the distal end of the reference electrode.

The invention relates to the technical field of medicaments, in particular to application of tamoxifen in preparation of a medicament for protecting retina photoreceptor cells. According to the application, mouse models with subretinal hemorrhage caused by an autologous blood injection mode are adopted; research shows that the survival rate of the retina photoreceptor cells which are in contact with blood can be improved, the apoptosis rate of the retina photoreceptor cells can be reduced, and the thickness of a retina outer nuclear layer can be maintained by giving the tamoxifen. A protectingeffect on the retina photoreceptor cells can be applied in a protective manner, namely, the tamoxifen is used when new vessels do not burst. Based on experimental results, the protecting effect can also be achieved on surviving retina photoreceptor cells in a retina even after bleeding. The tamoxifen can change an electroretinogram waveform of a normal mouse, which is one of the mechanisms for protecting the retina photoreceptor cells.

Systems, methods, and computer readable media for determining cognitive impairment (CI) in patients are provided herein. Various regional structural-functional parameters of the retina can serve as biomarkers for the detection of CI. The method can include forming a database including a quantification of retinal structure and retinal function of a plurality of eyes associated with a plurality of patients, providing a baseline cognitive impairment (CI) reference. The method can include determining a measure of functionality of neurons in the retina based on an electroretinogram (ERG) of a patient. The method can include determining a structural measure of the first retina based on a generalized dimension spectrum and singularity spectrum of the skeletonized retinal image, and a lacunarity parameter of the skeletonized retinal image. The method can include determining a level of cognitive impairment based on the structural and functional measures.

The invention discloses a method for inducing spontaneous cataract by a medicine (a direction-regulating inducer MNU). The method comprises the following inducing steps: a, firstly, selecting 280 mice for research; b, after the step a is completed, placing the mice in free equipment of special pathogens, where water and foods are free to the mice; c, after the step b is completed, randomly dividing the mice into a common control group, an MNU group, an MNU+ melatonin group and an MNU+ blank group; and d, after the step c is completed, performing visual movement behavior test on the mice, determining a reaction threshold value through a function of correct tracking reaction, setting initial stimulation as a sine mode of 0.200 weeks / degree and fixed 100% comparison, and then performing electroretinogram examination on the mice. According to the invention, the melatonin is added into the inducer MNU, so that free radicals can be directly removed, the generation of endogenous antioxidant enzymes can be improved, the melatonin treatment is beneficial to the generation of Cu-Zn-SOD and MnSOD, and the levels of lipid and DNA peroxidation markers MDA and 8-OHdG are reduced.

In some embodiments, a system for providing a therapeutic treatment to a patient's eye includes a treatment beam source configured to transmit a treatment beam along a treatment beam path. The system further includes a processor coupled to the treatment beam source, the processor being configured to direct the treatment beam onto retinal tissue of the patient's eye and deliver a series of short duration pulses from the treatment beam onto the retinal tissue at a first treatment spot to treat the retinal tissue. In some embodiments, a pre-treatment evaluation method using electroretinography (ERG) data may be used to predict effects of treatment beams at different power values and to determine optimal power values.

The invention discloses a method for recording a pattern electroretinogram under complicated electromagnetic interference conditions. The method comprises the following steps of: (1) disorderly closing and twisting five conducting wires connected with an amplifier; (2) opening a vision electrophysiological instrument, setting the range of transmission bands to be between 1 and 30 Hz, and setting the number of pattern reversal stimuli to be between 500 and 700 times when artifact rejection is forbidden; (3) placing five electrodes at preset positions respectively, and setting the distance between examined eyes and a display screen according to a detected object; and (4) beginning to record, and printing the pattern electroretinogram after the recording is finished. The recording method is simple and easy, the repeatability is high, results are accurate, normal pattern electroretinograms can be obtained under complicated electromagnetic interference conditions, and the recording efficiency of the pattern electroretinograms is improved; and the method has great significance for clinical diagnosis, visual function evaluation and objective understanding of the function of retinal ganglion cells of experimental animals.

The present invention refers to the field of ophthalmology, and in particular to that of devices and methods for supporting the diagnosis of important eye pathologies such as Age-related Macular Degeneration (AMD), Diabetic Retinopathy (DR), anomalies and dysfunctions of the retina and of sight in general such as degeneration of the retinal structure of the optical nerve and of the visual cortex. More specifically, the invention concerns a new device and method for recording the electroretinogram (so-called ERG) of an eye, i.e. the bioelectric response of the retina induced by a light stimulus, through the eyelid.

It is intended to provide a novel therapeutic method for a disease with apoptotic degeneration in eye tissue cells such as retinal pigment degeneration. Attention was paid on the concomitant administration of two neurotrophic factors: pigment epithelium-derived factor (PEDF) and fibroblast growth factor 2 (FGF2). The sites of actions are considered to be different between PEDF and FGF2. An SIV-PEDF vector and an SIV-FGF2 vector were constructed and administered to the subretinal space of an RCS rat, which is a disease model of retinal pigment degeneration, and their effects were evaluated. At4 weeks, 8 weeks and 12 weeks after the administration of the vectors, a significantly higher visual cell protection effect was obtained in a group with concomitant administration than in a group with sole administration. Further, the functional evaluation of retina was carried out by electroretinogram and an effect in the group with concomitant administration was significantly higher than in thegroup with sole administration. From the above results, it was found for the first time that the concomitant administration of PEDF and FGF2 has higher effects in the treatment of retinal pigment degeneration than conventional methods.

Apparatus for evoking and sensing ophthalmic physiological signals in an eye, the apparatus comprising: an elongated light pipe having a longitudinal axis, a distal end and a proximal end, the distal end terminating in a spheroidal recess; and an electrode having a distal end and a proximal end, the electrode being mounted to the elongated light pipe and extending proximally along the elongated light pipe so that the distal end of the electrode terminates at the spheroidal recess at the distal end of the elongated light pipe.

Apparatus for use in performing electroretinography on a test subject, the apparatus comprising: at least one electrically conductive thread, the at least one electrically conductive thread comprising a first end and a second end, wherein the first end of the at least one electrically conductive thread is configured to mount to skin on one side of an eye of the test subject and the second end is configured to mount to skin on the opposite side of the eye of the test subject, such that the at least one electrically conductive thread is in contact with a surface film of an eye; and an electrically non-conductive coating applied to at least one region of the at least one electrically conductive thread, whereby to electrically isolate the at least one region of the at least one electrically conductive thread from the eye.

A wearable device for performing an electroretinogram examination on a wearer may have a housing defining a first compartment and a second compartment. Each of the first compartment and the second compartment may include: a stimulation light source; a focused light source; an active electrode configured to engage the skin of the wearer; and a reference electrode spaced apart from the active electrode and configured to engage the skin of the wearer. A processor may be communicatively coupled to the stimulation light source, the active electrode, and the reference electrode of each of the first compartment and the second compartment of the housing. A memory may be in communication with the processor. The apparatus may perform a method comprising: flashing the stimulation light source of the first compartment; and storing a signal from the active electrode of the first compartment. The housing may further include a ground electrode.

The invention discloses a method for recording a pattern electroretinogram under complicated electromagnetic interference conditions. The method comprises the following steps of: (1) disorderly closing and twisting five conducting wires connected with an amplifier; (2) opening a vision electrophysiological instrument, setting the range of transmission bands to be between 1 and 30 Hz, and setting the number of pattern reversal stimuli to be between 500 and 700 times when artifact rejection is forbidden; (3) placing five electrodes at preset positions respectively, and setting the distance between examined eyes and a display screen according to a detected object; and (4) beginning to record, and printing the pattern electroretinogram after the recording is finished. The recording method is simple and easy, the repeatability is high, results are accurate, normal pattern electroretinograms can be obtained under complicated electromagnetic interference conditions, and the recording efficiency of the pattern electroretinograms is improved; and the method has great significance for clinical diagnosis, visual function evaluation and objective understanding of the function of retinal ganglion cells of experimental animals.

The embodiment of the invention discloses a contact lens type wireless flexible electroretinogram signal detection system and method. The system comprises energy transmission equipment and a contact lens type electroretinogram detection device, wherein the energy transmission equipment worn in front of the eyes comprises a signal generation circuit and an energy transmitting coil, and the energy transmission equipment acquires an electric signal and wirelessly transmits the electric signal to the contact lens type electroretinogram detection device; the contact lens type electroretinogram detection device worn on the surface of the eyeball comprises a signal acquisition electrode, an energy receiving coil and a signal processing main chip, and the energy receiving coil wirelessly receives the electric signal to drive the signal processing main chip; and an electroretinogram signal acquired by the signal acquisition electrode from the cornea is processed by the signal processing main chip and then is wirelessly transmitted to an upper computer to be displayed. By adopting the technical scheme of the embodiment of the invention, a set of huge electroretinogram detection system is concentrated on a contact lens type flexible device in combination with a flexible electronic technology and a signal processing main chip, so that a miniaturized and wireless visual electrophysiological instrument is realized.

The invention relates to the technical field of medicaments, in particular to application of tamoxifen in preparation of a medicament for protecting retina photoreceptor cells. According to the application, mouse models with subretinal hemorrhage caused by an autologous blood injection mode are adopted; research shows that the survival rate of the retina photoreceptor cells which are in contact with blood can be improved, the apoptosis rate of the retina photoreceptor cells can be reduced, and the thickness of a retina outer nuclear layer can be maintained by giving the tamoxifen. A protectingeffect on the retina photoreceptor cells can be applied in a protective manner, namely, the tamoxifen is used when new vessels do not burst. Based on experimental results, the protecting effect can also be achieved on surviving retina photoreceptor cells in a retina even after bleeding. The tamoxifen can change an electroretinogram waveform of a normal mouse, which is one of the mechanisms for protecting the retina photoreceptor cells.

Apparatus for evoking and sensing ophthalmic physiological signals in an eye, the apparatus comprising: an elongated light pipe having a longitudinal axis, a distal end and a proximal end, the distal end terminating in a spheroidal recess; and an electrode having a distal end and a proximal end, the electrode being mounted to the elongated light pipe and extending proximally along the elongated light pipe so that the distal end of the electrode terminates at the spheroidal recess at the distal end of the elongated light pipe.

The invention discloses an experimental device and method for guiding a mouse to find an escape platform through visual clues. The experimental device is characterized by comprising a base with a circular water tank, a center platform, the escape platform and an LED; LED flickering is used as a visual clue, so that the experimental mouse is guided to swim to the escape platform and escape is realized; and the visual function of the experimental mouse can be quantitatively analyzed according to recorded escape time. The experimental device and method have the advantages that compared with conventional electroretinogram or visual evoked potential detection, anesthesia is not needed, noninvasive detection can be achieved, visual behaviors serve as the research basis, the detected visual function range can cover sn area from retina to cerebral visual cortex center and other cerebral cortex areas related to the visual center, and is the experimental device and method are associated with a motion system.