6 results about "Outer nuclear layer" patented technology

The present disclosure relates to compositions, methods and related uses for preventing, inhibiting, ameliorating or delaying (slowing): (i) the thinning of the retinal outer nuclear layer (ONL), and / or (ii) reduction in total retinal thickness in a subject. The present disclosure further relates generally to compositions, methods and related uses for protecting: (i) the retinal outer nuclear layer (ONL) and / or the retina from light- or age-induced damage, and / or (ii) photoreceptors from light- or age-induced damage. In particular, the present technology relates to administering bevemipretide, or a pharmaceutically acceptable salt, stereoisomer, tautomer, hydrate, and / or solvate thereof to subjects in need thereof.

The present invention belongs to the field of biotechnology, and discloses a capsid protein mutant that improves the infectivity of AAV to eye tissues and its application. By inserting AAVRFDGTERAA and RQYSDAVRAE at amino acid positions 587 and 588 corresponding to the wild-type AAV2 virus capsid protein, the capsid protein mutants AAV2-NE01 and AAV2-NE02 are obtained. The virus yields of AAV2-NE01 and AAV2-NE02 are 1.96 times and 1.20 times that of AAV2-WT. After intravitreal injection, they can preferably infect various layers of cells from the ganglion cell layer (GCL), inner nuclear layer (INL) to outer nuclear layer (ONL) of the NHP retina and the trabecular meshwork region, with a high infection positive rate, strong fluorescence intensity, strong retinal penetration ability, and can infect the nuclear part and inner segment of the optic nerve. It has good application prospects and is expected to be developed into an AAV vector for treating eye diseases.

The invention belongs to the field of natural products, and provides chrysanthemum essential oil with a function of improving dry age-related macular degeneration. The chrysanthemum essential oil contains up to 168 compounds, more comprehensive biological activity support is provided for treatment, experiments prove that the essential oil can significantly optimize the retina structure of macular mice, specifically, the inner nuclear layer and the outer nuclear layer are closely arranged, the total thickness of the retina is significantly increased, the retinal pigment epithelium is more closely arranged, and the effect of improving the retina structure is achieved. Therefore, the polypeptide has the potential of improving the dry age-related macular degeneration function.

The present disclosure relates to compositions, methods and related uses for preventing, inhibiting, ameliorating or delaying (slowing): (i) the thinning of the retinal outer nuclear layer (ONL), and / or (ii) reduction in total retinal thickness in a subject. The present disclosure further relates generally to compositions, methods and related uses for protecting: (i) the retinal outer nuclear layer (ONL) and / or the retina from light- or age-induced damage, and / or (ii) photoreceptors from light- or age-induced damage. In particular, the present technology relates to administering bevemipretide, or a pharmaceutically acceptable salt, stereoisomer, tautomer, hydrate, and / or solvate thereof to subjects in need thereof.

This invention discloses the application of disodium 4,4'-diisothiocyanate-2,2'-stilbene sulfonate in the preparation of drugs for the prevention, delay, and / or treatment of blue light-induced retinal damage. It belongs to the field of biomedical technology. This invention demonstrates for the first time that sodium DIDS can effectively protect photoreceptor cells from blue light damage: at the cellular level, sodium DIDS can restore mitochondrial membrane potential, increase ATP levels, reduce reactive oxygen species accumulation, and inhibit mitochondrial-dependent apoptosis; at the animal level, intravitreal injection of sodium DIDS can improve vision in mice exposed to blue light, restore the amplitude of a-waves and / or b-waves in electroretinograms, and protect the outer segment length and outer nuclear layer thickness of cone cells. Sodium DIDS provides a novel therapeutic strategy for blue light-induced retinal photodamage through multi-target synergistic protection of mitochondrial function.

The invention relates to the field of application of natural products, in particular to application of a Chinese wolfberry extract in prevention and / or treatment of age-related retinopathy. The fructus lycii extract can increase the number of photoreceptor cells in age-related retina, improve the signal transmission capacity of an inner nuclear layer of the retina, increase the total thickness of the age-related retina and increase the thickness of an outer nuclear layer of the age-related retina.