12 results about "Retinal detachment" patented technology

A system for detecting retinal detachment is provided herein. The system includes an imaging device configured to capture a retinal fundus image of an individual, a processor, and a memory storing instructions. When executed by the processor, the instructions cause the system to preprocess the retinal fundus image to remove extraneous background information and enhance retinal features, input the preprocessed retinal fundus image into a trained machine learning model, generate a determination of whether the retinal fundus image indicates presence of retinal detachment using the trained machine learning model, and output the determination to a user interface. The machine learning model is trained on a set of labeled retinal fundus images to classify images as indicating presence or absence of retinal detachment.

The invention relates to the technical field of image analysis, in particular to a retina detachment grading method and system based on a multi-mode fundus image, and the method comprises the following steps: obtaining a fundus image gray boundary and extracting a mutation point, calculating the gray difference of adjacent pixels and comparing a trend baseline to screen the mutation point, calculating a path direction and screening a consistent path segment, extracting an unstable path through an ST-CRF model to generate a separation preliminary path set, extending the unstable path to screen a candidate area, calculating a direction change rate and mutation times to extract a separation candidate path segment, labeling a grade label through a support vector machine model, and fusing an expansion trend and a grading result to construct the multi-modal visual network. According to the method, a real path is tracked and a false separation path is eliminated by extracting a sudden change point in combination with gray difference and trend judgment, an unstable path section is analyzed and candidate area detection is enhanced, grade judgment is carried out through an SVM, an intervention map is generated, and visual guidance and intervention are carried out.

Provided herein are solid forms, e.g., polymorphs, of 2-(3-((7R,8aS)-7-fluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(5-methyl-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)azetidin-3-yl)acetonitrile, which are useful for treating kinase-related diseases or disorders. The solid forms, and compositions thereof, are useful for treating diseases in a subject, including, but not limited to, ocular diseases such as glaucoma, ocular hypertension, ocular wound repair, neurodegenerative ocular diseases, retinal detachment, and non-ocular diseases such as nerve injury, or skin wound repair, or inflammatory diseases, among others. (Compound 1) TIFF2026501674000028.tif4839

This invention provides a magnetically controlled microrobot system and its usage method, relating to the interdisciplinary field of ophthalmic medical devices and magnetically controlled robots. The magnetically controlled microrobot system includes an electromagnetic drive device, a magnetic microrobot, and a control device. The electromagnetic drive device includes a first electromagnetic array and a second electromagnetic array whose magnetic field directions are at an angle. The first and second electromagnetic arrays together form a driving magnetic field that can be controlled in multiple dimensions. The magnetic microrobot includes a magnetic body for responding to the driving magnetic field to perform multi-degree-of-freedom motion and / or posture adjustment. The control device is communicatively connected to the magnetic electromagnetic drive device and is used to control the electromagnetic drive device to generate a target magnetic field to drive the magnetic microrobot to perform the target operation. When used to treat rhegmatogenous retinal detachment, this magnetically controlled microrobot system enables controllable, multi-degree-of-freedom, and precise control of the magnetic microrobot within the limited space inside the eye.

Disclosed are acid-sensing ion channel (ASIC) inhibitors and their use for treating or inhibiting the development of a condition in which inhibiting an ASIC stimulates or effects treatment or inhibition of the development of the condition. More particularly, this invention relates to proteinaceous ASIC inhibitors and their use for treating or inhibiting the development of a neurological condition, neuronal damage, ischaemia, pain, ischaemia-reperfusion injury, a cancer, chronic kidney disease, acute kidney injury, arthritis and retinal detachment. The ASIC inhibitors are also useful for inhibiting damage to an organ during organ transplantation.

The invention provides a three-dimensional high-frequency ultrasonic ophthalmic examination device and method, equipment and a medium. The three-dimensional high-frequency ultrasonic ophthalmic examination device comprises a mechanical arm, an ultrasonic probe and a host, wherein the ultrasonic probe is clamped at the tail end of the mechanical arm; in the dragging mode, the mechanical arm moves to adjust the position of the ultrasonic probe; in an imaging mode, the mechanical arm locks the joint so as to keep the position of the ultrasonic probe unchanged; and in the scanning process, the host sends a trigger signal to the ultrasonic probe, so that the ultrasonic probe performs rotary scanning imaging, records the real-time angle of the micro motor, emits an acoustic beam and records an echo signal until the whole scanning process is completed. And after scanning is finished, signal processing and image reconstruction are carried out. According to the invention, scanning and reconstruction of eyeballs are realized by using a linear array ultrasonic probe rotation mode. The result can visually present the spatial form of the eye structure and the relationship between the eye structure and surrounding tissues, the limitation that traditional two-dimensional ultrasound depends on doctor imagination splicing is changed, and the diagnosis precision of diseases such as glaucoma, intraocular tumors and complex retinal detachment is improved.

The invention relates to the field of ophthalmology, in particular to application of an NK1.1 scavenger (cloned PK136) in preparation of a medicine for treating and / or relieving acute retinal injury. The invention provides application of an NK1.1 scavenger in preparation of a medicine for treating and / or relieving acute retinal injury. According to the invention, emergency treatment can be carried out during acute retinal injury (such as traffic accidents and retinal detachment), retinal injury is relieved, sufficient time is provided for treatment methods such as operations, and injury is reduced to the minimum.

The present invention relates to a compound of formula (I) wherein R1 and R2 are as defined herein, a pharmaceutical composition comprising such compound for treatment of a PGD2-mediated disorder including, to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.

The invention discloses a light anchor umbrella bag type sclera outer jacking system and method for retina detachment treatment, the jacking system comprises a water filling bag body, a light-emitting capsule and a water injection mechanism, the light-emitting capsule is inserted in an inner cavity of the water filling bag body, the water injection mechanism is communicated with the inner cavity of the water filling bag body through an injection pipe, and the water injection pipe is communicated with the water filling bag body. The water injection mechanism can inject water into the inner cavity of the water filling bag body through the injection pipe, and the light-emitting capsule can emit light in the water filling bag body after water injection. The jacking method comprises the following steps: step 1, air tightness detection; step 2, implanting an optical anchor; step 3, water filling operation; and step 4, adjusting water pressure. The device has the beneficial effect of being more beneficial to smooth operation. And the capsule body can be accurately implanted into a required position according to the guidance of the light source. And the mechanical injury to a patient is greatly reduced.

The present invention includes a device for effecting deformation of a sclera of an eye, including an expandable, mesh tube having holes dispersed through an entire surface thereof and with first and second tapered ends, and inserted unexpanded to deform the sclera when expanded. A central portion is intrascleral, with the first and second tapered ends external to the sclera on top of an intact scleral surface to deform during expansion, and simultaneously causes the sclera to be deformed so that the sclera moves towards the inside of the eye while simultaneously causing the sclera to move towards the outside of the eye. The mesh tube includes struts, connecting points of the struts are of different sizes, the first and second tapered ends and the connecting points within the tapered ends are thicker than the connecting points of the mesh tube, and the mesh tube includes fixation tabs.

The invention discloses a method, a device and a system for constructing a screening prediction model of high myopia complications. The method comprises the following steps: acquiring conventional blood detection parameters; modeling by adopting different machine learning algorithms according to the conventional blood detection parameters; and evaluating the established model through a plurality of performance indexes. By the adoption of the technical scheme, screening of cataract, macular degeneration, choroidal neovascularization, glaucoma and retinal detachment complications of high-myopia patients is achieved.

The application discloses a silicone oil filling simulation method and device for assisting treatment of retinal detachment, and the method comprises the following steps: constructing an eyeball wall model of a patient according to an elastic solid modeling method, and maintaining the incompressibility of the eyeball wall by adopting an implicit iterative correction pressure method based on the number density; for the scene of filling silicone oil in the intraocular cavity during surgery, the silicone oil is regarded as a high-viscosity incompressible Newton fluid, and the interaction between the silicone oil and the eyeball wall is simulated according to the coupling method between the fluid and the elastic solid; and the three-phase coupling environment composed of water, silicone oil and the eyeball wall generated by the aqueous humor entering the vitreous cavity after surgery is simulated, and the emulsification phenomenon of the water and the silicone oil occurring at the immiscible boundary is simulated. According to the technical scheme of the application, the eyeball wall is constructed according to the elastic solid modeling method, the filling environment is visualized, and the dynamic interaction generated by the filling is simulated through the volume incompressible model based on the number density, so that accurate quantitative analysis can be provided for the surgical treatment.