Glycollic acid grafted chitosan copolymer, preparation method thereof, and application of glycollic acid grafted chitosan copolymer used as scleral bucking material

A technology of chitosan copolymer and glycolic acid, which is applied in the fields of medicine, chemical industry and medical equipment, can solve the problems of reduced biocompatibility, short maintenance time of scleral ridge, poor hydrophilicity, etc., and achieves good biocompatibility, surface Activity is beneficial, no toxic side effects

Active Publication Date: 2012-06-27
JIANGSU YITONG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These materials all have different degrees of defects: for example, the degradation product of PLA is lactic acid, which can lead to aggravation of the inflammatory response after local tissue accumulation, and the degradation is too slow; The ridge maintenance time is too short, and there are a large number of ester bonds in PGA, which has poor hydrophilicity and reduces its biocompatibility with other substances; phosphate-carbonate copolymers have poor biocompatibility and slow degradation; in addition, The mechanical properties of the above new types of buckle materials are significa

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 glycolic acid grafted chitosan copolymer

[0023] (1) Glycolic acid was added to chitosan for graft copolymerization. The reaction temperature, vacuum degree, molar ratio of chitosan to glycolic acid and reaction time are shown in Table 1;

[0024] (2) Fully dissolve the reactant obtained in step (1) with 0.01mol / L acetic acid or 0.02mol / L benzoic acid, add glycolic acid to the solution, vacuum dry the solution, rinse with deionized water after drying, and then freeze Dry to obtain glycolic acid grafted chitosan copolymer. The degree of substitution of the copolymer was determined by UV spectroscopic method by salicylaldehyde method. The results are shown in Table 1.

[0025] Table 1 Reaction conditions and results

[0026] Chitosan: glycolic acid (molar ratio) temperature Vacuum time (h) Degree of substitution Yield 1 1:0.5 25 0.01 6 7.5% 44% 2 1:2 50 0.08 18 12.7% 57% 3 1:6 ...

Embodiment 2

[0027] Embodiment 2 The preparation of glycolic acid grafted chitosan copolymer scleral buckle

[0028] Add 10mg of glycolic acid to 1.5g of chitosan for graft copolymerization, the reaction temperature is 90°C, the vacuum degree is 0.01 atmospheric pressure, and the reaction time is 20 hours. The obtained reactant is fully dissolved with 0.01mol / L acetic acid, and the solution is added to glycolic acid , the solution is injected into the scleral buckle mold, vacuum dried, rinsed with deionized water after drying, and then freeze-dried to obtain the glycolic acid grafted chitosan copolymer scleral buckle.

[0029]

Embodiment 3

[0030] Example 3 Glycolic acid grafted chitosan copolymer effectiveness and safety of scleral buckle

[0031] Take 40 New Zealand big-eared white rabbits implanted with polyglycolic acid grafted chitosan scleral buckle material, 20 implanted with silicon sponge as a control, and 40 rabbits implanted with polyglycolic acid grafted chitosan scleral buckle material 20 of them are only used to measure the degradation rate. The other 20 rats were compared with the 20 rats in the silicon sponge group, and the following examinations were carried out at 2 weeks, 1 month, 3 months, and 6 months after the operation: Use B-ultrasound to measure the height of the scleral compression ridge and its descending degree to detect its effectiveness and degradation rate; at the above time points, the anterior segment of the rabbit was photographed to observe whether there were complications such as infection and prolapse of the implant; electroretinogram was performed on the postoperative rabbit ...

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PUM

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Abstract

The invention discloses a glycollic acid grafted chitosan copolymer, a preparation method thereof, and application of the glycollic acid grafted chitosan copolymer used as a scleral bucking material. On the premise of not using any catalyst, polyglyclic acid is grafted on a chitosan molecular chain by a graft copolymerization method under the reaction conditions of low-temperature heating and lowvacuum degree, performance of polyglyclic acid and chitosan is improved by using advantages of the polyglyclic acid and chitosan, and defects of polyglyclic acid and chitosan are overcome. The obtained product has high biocompatibility, biodegradability, and surface activity and good biomechanical properties and can be effectively used as external scleral implant for treating rhegmatogenous retinal detachment.

Description

technical field [0001] The invention relates to the fields of medicine, chemical industry and medical equipment, in particular to a glycolic acid grafted chitosan copolymer, a preparation method thereof and an application as a scleral buckle material. Background technique [0002] Rhegmatogenous retinal detachment (RRD) is a serious blinding eye disease. Once diagnosed, surgery is required as soon as possible. Scleral buckling and vitreous surgery are currently the main surgical methods for clinical treatment of RRD. Vitreous surgery is mainly used for complex RRD, while scleral buckling is the most commonly used and preferred surgical method for simple RRD. Scleral buckling includes external scleral compression, cerclage and scleral shortening. Its purpose is to cause the inward depression of the sclera on the eyeball wall to press the fracture hole, relieve or eliminate the pulling of the vitreous, The vitreous cavity is narrowed and the detached retinal neuroepithelium i...

Claims

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Application Information

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IPC IPC(8): C08B37/08C08G63/685A61L27/20
Inventor 杨宇民张添
Owner JIANGSU YITONG BIOTECHNOLOGY CO LTD
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