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Proliferative vitreoretinopathy (PVR) is a disease that develops as a complication of rhegmatogenous retinal detachment. PVR occurs in about 8–10% of patients undergoing primary retinal detachment surgery and prevents the successful surgical repair of rhegmatogenous retinal detachment. PVR can be treated with surgery to reattach the detached retina but the visual outcome of the surgery is very poor.
Application of YTHDC1 inhibitor in preparation of medicine for preventing and treating proliferative vitretinopathy
PendingCN121513012AOrganic active ingredientsSenses disorderPharmacy medicinePVR - Proliferative vitreoretinopathy
The invention belongs to the technical field of prevention and treatment of proliferative vitretinopathy, and particularly discloses application of a YTHDC1 inhibitor in preparation of drugs for preventing and treating proliferative vitretinopathy. Cell experiments and animal experiments prove that the YTHDC1 inhibitor can effectively inhibit the EMT process of RPE cells and delay the disease progress of a proliferative vitreoretinopathy animal model for the first time, and the YTHDC1 inhibitor has the potential of serving as a new strategy for preventing and treating PVR and has a good application prospect.
Owner:HENAN PROVINCIAL EYE HOSPITAL (HENAN PROVINCIAL EYE INST)