Methods, polymer-containing formulations, and polymer compositions for treating retinal detachment and other ocular disorders

A polymer and retinal technology, applied in the direction of unsaturated alcohol copolymer adhesives, adhesive types, adhesives, etc., can solve the problems of injecting hydrogel, inability to use small needles, lack of biocompatibility, etc.

Inactive Publication Date: 2020-10-02
皮库斯治疗公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For silicone oil, although used when localization is not possible or when air travel is required, it is still a poor tamponade and requires a second removal procedure
[0010] Many different tampons have been studied; however, they are generally limited here as tampons due to, for example, toxicity, emulsification, insufficient degradation rates, and/or being pro-inflammatory
Certain hydrogels have also been suggested in the past; however, those tested suffered from variou

Method used

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  • Methods, polymer-containing formulations, and polymer compositions for treating retinal detachment and other ocular disorders
  • Methods, polymer-containing formulations, and polymer compositions for treating retinal detachment and other ocular disorders
  • Methods, polymer-containing formulations, and polymer compositions for treating retinal detachment and other ocular disorders

Examples

Experimental program
Comparison scheme
Effect test

no. 1 approach --

[0065] First Embodiment - Contacting Retinal Tissue in a Subject's Eye with a Hydrogel

[0066] One aspect of the invention provides a method of contacting retinal tissue in the eye of a subject with a hydrogel. In certain embodiments, the method comprises (a) administering to the vitreous cavity of the subject's eye an effective amount of (i) an electronically functional polymer and (ii) a polymer comprising a core functional polymer, a poly(ethylene glycol) polymer, and an ophthalmic formulation of an aqueous pharmaceutically acceptable carrier; and (b) reacting the core functional polymer with the electronic functional polymer to form a hydrogel in the vitreous cavity; wherein the core functional polymer is (i ) multiple -OH groups, (ii) multiple mercapto functional groups -R 1 -SH, where R 1 is an ester-containing linker, and (iii) optionally one or more -OC(O)-(C 1 -C 6 an alkyl) group substituted biocompatible polyalkylene polymer; and wherein the electronically fun...

no. 2 approach --

[0088] Second Embodiment - Supporting Retinal Tissue

[0089] Another aspect of the invention provides a method of supporting retinal tissue in the eye of a subject, the method comprising: (a) administering to the vitreous cavity of the subject's eye an effective amount of (i) an electronically functional polymer and (ii) a polymer comprising a nuclear functional polymer an ophthalmic formulation of a substance, a poly(ethylene glycol) polymer, and an aqueous pharmaceutically acceptable carrier; and (b) reacting the core-functional polymer with the electronic-functional polymer to form a hydrogel in the vitreous cavity; wherein the core functional polymer is covered with (i) multiple -OH groups, (ii) multiple mercapto functional groups -R 1 -SH, where R 1 is an ester-containing linker, and (iii) optionally one or more -OC(O)-(C 1 -C 6 an alkyl) group substituted biocompatible polyalkylene polymer; and wherein the electronically functional polymer is a biocompatible polyme...

no. 3 approach --

[0110] Third Embodiment - Treating a Subject with Retinal Detachment

[0111] Another aspect of the invention provides a method of treating a subject with retinal detachment, the method comprising: (a) administering to the vitreous cavity of the eye of the subject having at least a portion of the detachment of retinal tissue an effective amount of (i) an electronically functional polymer and (ii) an ophthalmic formulation comprising a core functional polymer, a poly(ethylene glycol) polymer, and an aqueous pharmaceutically acceptable carrier; and (b) reacting the core functional polymer with the electronic functional polymer to A hydrogel is formed in the vitreous cavity; wherein the hydrogel supports the retinal tissue during reattachment of the portion of the retinal tissue; wherein the core functional polymer is coated with (i) multiple -OH groups, (ii) multiple thiol functional groups -R 1 -SH, where R 1 is an ester-containing linker, and (iii) optionally one or more -...

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Abstract

Provided are methods, polymer-containing formulations, and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions or polymer-containing formulations that can form a hydrogel in the eye of a subject. In certain embodiments, the hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of -OH groups, (ii) a plurality of thio-functional groups -R1-SH wherein R1 is an ester-containing linker, and (iii) optionally one or more -OC(O)-(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups. In certain embodiments, the hydrogel is formed by curing a biocompatible polymer described herein, such as a thermosensitive polymer, nucleo-functional polymer, electro-functional polymer, or pH-sensitive polymer.

Description

[0001] Cross-references to earlier filed applications [0002] This application claims the benefit of U.S. Provisional Application no. 62 / 616,610, filed January 12, 2018, and U.S. Provisional Application no. 62 / 616,614, filed January 12, 2018, each of which is incorporated by reference in its entirety into this article. technical field [0003] Methods and polymer-containing formulations or polymer compositions for treating retinal detachment and other ocular disorders are provided, wherein the methods employ a polymer composition that can form a hydrogel in the eye of a subject. Ophthalmic formulations comprising a polymer composition capable of forming a hydrogel in the eye of a subject are also provided. Background technique [0004] Retinal disorders such as retinal detachment, retinal tear and macular hole are important causes of vision loss in subjects. Retinal detachment is characterized by the separation of the sensory layer of the retina from its underlying retina...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/52A61L27/56
CPCA61L27/50A61L27/58A61L2400/06A61L2430/16A61L27/52A61L27/26C09J129/04C08L2205/025C08L2205/03C08G65/3322C08G59/46C08G59/54C08G59/1477C09J163/00A61L27/16C08L29/04C08L71/02C08L2203/02C09J141/00A61L2400/18
Inventor 劳伦斯·A·罗思詹姆斯·安托尼·斯特法特三世托马什·帕维尔·斯特雷耶夫斯基约翰·所罗门·加尔内
Owner 皮库斯治疗公司
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