Application of transthyretin in transferring fusion protein into eyes

A technology of thyroxine protein and protein, which is applied in the application field of transthyretin carrying exogenous protein to the eye through the eye barrier, which can solve the problems of short half-life and low delivery efficiency, and achieve good biocompatibility and safety effect
CN110960687AInactive Publication Date: 2020-04-07TONGYAN (SHANGHAI) MEDICAL EQUIPMENT CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TONGYAN (SHANGHAI) MEDICAL EQUIPMENT CO LTD
Publication Date
2020-04-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of transthyretin in transferring fusion protein into eyes, belonging to the technical field of protein engineering. The invention provides a method for allowing foreign protein to pass through eye barriers and to be conveyed into eyes through fusion expression of transthyretin as shown in SEQ ID NO.1 and the foreign protein. The results of animal experiments prove that as the fusion protein prepared in the invention is used for eye drop treatment on rats and rabbits, foreign protein can be rapidly and effectively conveyed to fundus. The transthyretin used inthe method is derived from a human body, has good biocompatibility and safety in the human body, and has important application prospects when used as a substitute of injection drugs in the field of medicine.
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Description

technical field

[0001] The invention relates to the application of transthyretin transport fusion protein into the eye, especially the application of transthyretin carrying exogenous protein to the eye through the eye barrier, and belongs to the technical field of protein engineering. Background technique

[0002] The treatment of eye diseases requires the effective delivery of drugs into the eye, especially age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, glaucoma-induced nerve changes, etc.; however, there are many barriers in the eye , the effective delivery of drugs into the eye is full of challenges. Therefore, ocular drug delivery systems have received extensive attention recently. At present, eye drops are the most widely used dosage form in the clinical treatment of eye diseases, but they are quickly lost from the ocular surface, and their bioavailability is relatively low. In response to this situation, the formulations of microspheres...

Claims

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