2 results about "Oculopathy" patented technology

The present invention provides a TSHR antagonist compound of formula (I), a pharmaceutical composition, a method for preparing same, and use thereof. The compound has a good TSHR antagonistic effect and is used for treating thyroid-related disorders and / or diseases, such as hyperthyroidism, Graves' disease, Graves' ophthalmopathy, and thyroid-associated ophthalmopathy, and for preparing a medicament for such disorders or diseases.

Disclosed herein are compounds useful for the inhibition of insulin-like growth factor 1 receptor (IGF-1R). The compounds have a general Formula (I): or pharmaceutically acceptable salts thereof, wherein the variables of Formula (I) are as defined herein. Also provided herein are pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, thyroid-associated ophthalmopathy, Graves' opthalmopathy or Graves' orbitopathy. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).