19 results about "Cataract patient" patented technology

The invention relates to an exosome composition, application thereof and exosome eye drops, and relates to the technical field of pharmaceutical preparations, and the exosome composition is composed of a mesenchymal stem cell exosome and a rabdosia lingua extract in a weight ratio of (5-10): (13-21). The exosome composition is composed of the mesenchymal stem cell exosome and the rabdosia lophanthoides extract in a proper proportion, and the mesenchymal stem cell exosome and the rabdosia lophanthoides extract are matched for use, so that the exosome composition has an excellent treatment effect on cataract and can be applied to preparation of products such as eye drops and the like, and a new treatment means is provided for cataract patients. In addition, the exosome eye drops provided by the invention do not contain side-effect components such as preservatives and hormones, have no obvious irritation and can be used for a long time.

The invention relates to a flexible glue material with PCO resistance and application thereof, and provides a flexible glue type IOL material which can be injected, adapts to minimally invasive surgery and has infinite zooming capability and biological resistance, a precursor of the material can be injected into an intraocular capsular bag through an injector, an implanted wound is extremely small, the precursor is crosslinked into flexible glue in situ in the intraocular capsular bag, and the flexible glue can be used as an intraocular material. The performance of natural crystals of young people is simulated, so that the cataract patient recovers the natural regulation function after the operation. The implanted flexible glue has the characteristics of cell adhesion resistance, protein deposition resistance and the like, PCO is avoided, compared with an existing IOL product, the service life is longer, and meanwhile better visual quality is provided for a patient.

The invention discloses an integrated imaging light field display method and device with a cataract correction function. The method comprises the following steps: acquiring the position and size of an eye turbid area of a patient to be corrected; if the size of the eye turbid area is smaller than or equal to a preset size, determining a target pixel position on the micro-display based on the position of the eye turbid area, and turning off a light-emitting unit at the target pixel position to obtain a corrected image; if the size is larger than the preset size, according to the position of the area with the large turbid area, the aberration type of the patient to be corrected is obtained by turning off the light-emitting unit at the position of the target pixel and then analyzing the eye data, a corresponding point spread function is determined according to the aberration type, Fourier transform is carried out on the obtained blurred image, and the image is obtained. And correcting the transformed image by using a corresponding correction function obtained by the point spread function to obtain a corrected image. Through the method, the correction precision of the cataract patient is improved.

The application discloses an integrated imaging light field display method and device with cataract correction function, and the position and size of an eye turbidity area of a patient to be corrected are acquired; if the size of the eye turbidity area is less than or equal to a preset size, the position of the eye turbidity area is used to determine a target pixel position on a micro display, the light emitting unit at the target pixel position is turned off, and a corrected image is obtained; if the size is greater than the preset size, the position of a turbidity area with a large size is used to analyze the eye data after the light emitting unit at the target pixel position is turned off, the type of aberration of the patient to be corrected is obtained, a corresponding point spread function is determined according to the type of aberration, the Fourier transform of a blurred image is performed, a transformed image is obtained, the transformed image is corrected by using a corresponding correction function obtained by using the point spread function, and a corrected image is obtained. Through the above method, the correction accuracy of a cataract patient is improved.

A nicotinamide-containing intraocular surgery perfusate, a preparation method therefor, and use thereof. Use of nicotinamide in an intraocular surgery perfusate. The intraocular surgery perfusate improved using nicotinamide can inhibit corneal endothelial cell damage caused by cataract ultrasonic emulsification surgery treatment, relieve corneal edema caused by cataract ultrasonic emulsification surgery, prevent the number of corneal endothelial cells from being significantly reduced due to surgery, promote the postsurgical recovery of corneal transparency, promote the recovery of the thickness of the cornea to a normal level, maintain the normal density and cellular morphology of the corneal endothelial cells and the regular expression of functional proteins, and reduce complications caused by cataract ultrasonic emulsification surgery. The present invention can provide an effective strategy for the rapid postsurgical recovery of normal visual function in cataract patients.

The present invention relates to a novel refractive intraocular lens (IOL) having a continuous range of view, extended depth of field (EDOF), capable of providing a continuous clear field of view for cataract patients when objects from far to near while minimizing halo and glare phenomena. The novel refractive EDOF continuous visual range artificial lens provided by the invention has the advantage that the extended focal depth can be provided, so that a patient can obtain continuous vision from a far position to a near position (35-40cm). The spherical aberration of each area on the front surface of the artificial lens is optimized, halo and glare are reduced to the maximum extent, the 60-degree refraction section of the fourth area is used for providing balanced energy distribution when the pupil diameter is large, the pupil is irrelevant to magnification distribution, and the lens magnification and the extension focal depth are not affected by the pupil size or light conditions. The partition modification of the intraocular lens can be used as a controllable switch, and the focal depth can be adjusted according to requirements, namely, the focal depth is adjusted from a far vision field to a near vision field or from the far vision field to a middle vision field.

The invention discloses a cataract vision real-time enhancement system and method based on a wavefront sensing technology, and the system comprises a camera module, a beam expander, a polarizing film, a beam splitter, a light modulation part, a scattering medium and a focusing lens, and the beam expander, the polarizing film, the beam splitter, the scattering medium and the focusing lens are sequentially connected. The light modulation part carries out light wave front phase modulation on the light beams separated by the beam splitter, and the camera module collects a clear image which is not disturbed by the scattering medium and a blurred image which is modulated by the light modulation part, penetrates through the scattering medium and is focused by the focusing lens. The target area image quality is optimized based on the clear image and the blurred image to optimize the phase of the light modulation component. According to the invention, the limitation of the existing cataract treatment method can be overcome, the visual sense of the cataract patient is enhanced in real time, and the life quality of the patient is improved.

To provide an extended depth of focus (EDOF) that provides a cataract patient with continuous vision from distance to near with minimal halo and glare, and an intraocular lens (IOL) that achieves continuous vision.SOLUTION: To obtain continuous vision from a long distance to a short distance near 40-35cm by providing the extension of a focal depth. The spherical aberration of each zone of the anterior surface of the intraocular lens is optimized to minimize halo and glare. The fourth zone 60 degree segment design of the present invention provides a balanced energy distribution at large pupil diameters and makes the lens pupil independent of power distribution. The lens power and its extended depth of focus are independent of pupil size and lighting conditions. Furthermore, the change of zone of the intraocular lens can be used as a controllable switch to change the depth of focus according to the demand from far vision to near vision or from far vision to intermediate vision.SELECTED DRAWING: Figure 1

This invention provides an application of type I interferon signaling pathway inhibitors in the preparation of drugs for treating age-related cataracts. By inhibiting type I interferon receptors, it can precisely intervene in the aging mechanism of lens epithelial cells, block the transmission of aging signals, and directly improve lens transparency, exhibiting higher therapeutic efficacy and targeting. The use of IFNAR inhibitors can effectively reverse the aging phenotype caused by STEAP3 deficiency, restore the proliferative capacity of lens epithelial cells, thereby maintaining lens transparency, significantly reducing surgical risks, and providing patients with an early intervention opportunity, delaying the onset and progression of cataracts. IFNAR inhibitors, through precise intervention in specific signaling pathways, have more significant therapeutic effects, and due to their targeting, have fewer side effects and are safer. They can not only improve existing cataracts but also play a preventive and delaying role in the early stages of cataracts. For patients with mild cataracts, the use of type I interferon receptor inhibitors can avoid premature surgical treatment, reducing patient dependence on surgery and also reducing the costs and risks associated with surgery.

The present invention discloses an IGFBP3 protein as a cataract marker and its application. The cataract biomarker is IGFBP3 protein, and the expression level of IGFBP3 protein is increased in cataract patients. The IGFBP3 protein provided in this application is used as a cataract marker and its application. When applied in clinical practice, it can achieve early diagnosis of cataracts, which is of great significance for preventing blindness in patients. Through early identification and intervention, visual impairment caused by cataracts can be reduced, thereby improving the quality of life of patients. In addition, the detection of IGFBP3 protein can also help evaluate the progression of the disease and the effect of treatment, and provide an important reference basis for clinical treatment. The introduction of this detection method can not only improve the diagnostic accuracy of cataracts, but also provide patients with more personalized treatment plans, thereby improving the long-term prognosis and quality of life of patients.

The present invention belongs to the technical field of drug preparation and relates to a nicotinamide-containing intraocular surgical irrigation solution and its preparation and application. The present invention provides the use of nicotinamide in an intraocular surgical irrigation solution. The present invention uses nicotinamide to improve the intraocular surgical irrigation solution, which can inhibit corneal endothelial cell damage caused by cataract phacoemulsification surgery, reduce corneal edema caused by cataract phacoemulsification surgery, avoid a significant decrease in the number of corneal endothelial cells caused by surgery, promote the recovery of corneal transparency after surgery, promote the recovery of normal corneal thickness, maintain the normal density, cell morphology, and regular expression of functional proteins of corneal endothelial cells, and reduce complications caused by cataract phacoemulsification surgery. The present invention can provide an effective strategy for the rapid recovery of normal visual function in cataract patients after surgery.

This invention discloses an AI-based intelligent prediction and assessment system for postoperative vision in cataract patients, comprising an information acquisition module, a macular OCT image acquisition module, an image analysis module, a model training module, a vision prediction module, and a treatment suggestion module. The information acquisition module collects basic information about the individual user; the macular OCT image acquisition module acquires macular OCT images of the patient; the image analysis module automatically extracts and analyzes the external morphological features of the macula in the images acquired by the macular OCT image acquisition module; the model training module trains the vision prediction module; the vision prediction module loads the optimal model parameters obtained from the model training module and uses them to predict the postoperative vision of cataract patients; the treatment suggestion module provides targeted treatment suggestions based on the predicted postoperative vision obtained from the vision prediction module. This invention can accurately and quickly predict the postoperative vision of cataract patients based on their preoperative macular OCT images.

The utility model discloses a nucleus pre-chopping device for scleronucleus cataract, and relates to the technical field of ophthalmologic surgical instruments, the nucleus pre-chopping device comprises a nucleus chopping head and a handle part, the nucleus chopping head is fixedly connected with the handle part, the nucleus chopping head is of a triangular body structure, one end, far away from the handle part, of the nucleus chopping head is a nucleus chopping tip, and the other end of the nucleus chopping head is provided with a cavity. One end, connected with the handle part, of the nucleus chopping head is a connecting surface end, the nucleus chopping tip end is provided with blunt round sawteeth, and the thickness of the nucleus chopping head is gradually increased from one side of the nucleus chopping tip end to one side of the connecting surface end. The application is beneficial to reducing the super-milk energy release of the patient with the dura-nucleus cataract, reducing the surgical risks of corneal injury, iris injury and the like of the patient, and improving the surgical efficiency and safety of the patient with the dura-nucleus cataract.

The utility model discloses a capsular membrane polisher used after a cataract operation. The capsular membrane polisher comprises a positioning bottom plate. The top ends of the positioning bottom plates are fixedly connected to the bottom ends of guide sliding rods at equal intervals, and reset springs are arranged on the outer walls of the middles of the guide sliding rods which are fixedly arranged at equal intervals. The device further comprises a suction mechanism arranged above the positioning bottom plate, the suction mechanism comprises a suction flat plate, and the corners of the four sides of the suction flat plate are fixedly connected to the lower portions of guide sliding rods which are arranged at equal intervals. Wherein a polishing mechanism is arranged above the positioning bottom plate, and the polishing mechanism comprises a polishing flat plate. According to the capsular membrane polisher used after the cataract operation, the positioning bottom plate of an arc-shaped structure is matched with the eyes of a cataract patient, the polishing mechanism and the suction mechanism which are mutually pressed are used for polishing and cleaning an inner capsular membrane and then cleaning the inner capsular membrane, and the capsular membrane is safely and effectively polished; the flexible effect of the liquid flow does not cause direct rigid damage to the capsule membrane.

The present invention proposes a method for analyzing aqueous humor based on a titanium oxide nanomaterial matrix, and the specific steps are as follows: titanium oxide nanomaterials and deionized water are configured into a material dispersion solution, wherein the mass volume ratio of titanium oxide nanomaterials to deionized water is in the range of 1-2 g / L, 1-2 μL of aqueous humor sample is deposited on a target plate, and after the sample is dried, 1-2 μL of material dispersion solution is applied thereon, and then the sample is subjected to MALDI-TOF-MS mass spectrometry analysis to obtain a metabolic fingerprint map, and then the method of machine learning is used to distinguish patients with cataracts related to different diseases. The present invention realizes the collection of metabolic fingerprint maps of aqueous humor samples by preparing a binary laser / desorption ionization matrix with high ionization efficiency, and can quickly distinguish cataracts related to senility, diabetes, and high myopia by combining the means of machine learning, and has broad application prospects for distinguishing cataracts related to different diseases and exploring the molecular mechanism of cataracts.

A soft gel material having anti-PCO properties and the use thereof. Provided is a "soft gel-type IOL material" that has injectability, suitability for minimally invasive surgery, a stepless zooming capability and biological resistance. A precursor of the material can be injected into an intraocular capsular bag by means of a syringe, resulting in an extremely small implantation incision, and then undergoes in-situ cross-linking into a soft gel in the intraocular capsular bag, mimicking the performance of a natural crystalline lens in young people, thereby enabling cataract patients to regain natural accommodation function after surgery. The implanted soft gel has properties such as anti-cell adhesion and anti-protein deposition, which prevent the occurrence of PCO. Compared with existing IOL products, the implanted soft gel has a longer service life while providing patients with better visual quality.

The present invention discloses a cataract vision intelligent prediction system and method based on slit lamp images, which relates to the field of medical image processing. The system includes: an information acquisition module, a data processing module, a model construction module, and a vision prediction module. The information acquisition module is used to obtain the preoperative BCVA and the BCVA one month after surgery of cataract patients. At the same time, the information acquisition module is also used to obtain the anterior segment slit lamp images of cataract patients. The data processing module is used to preprocess the anterior segment slit lamp images to obtain processed data. The model construction module is used to construct a vision prediction model based on the preoperative BCVA, the BCVA one month after surgery, and the anterior segment slit lamp images. The vision prediction module is used to predict the vision of cataract patients before and after surgery by using the vision prediction model. The present invention can quickly and accurately predict the BCVA of cataract patients under different degrees of lens opacity and their postoperative BCVA, improving work efficiency.

The present application relates to the technical field of medical health information and speech synthesis, and specifically discloses an intelligent voice reminding system for medication compliance of cataract patients, which comprises a user interaction terminal, a cloud collaborative processing platform and a medical data interface. The user interaction terminal determines the user's interactive state through multi-modal perception and local behavior recognition and reports it; the cloud platform dynamically decides the reminding time and content strategy through a dynamic strategy decision unit based on the user portrait, the medication task and the user state, and synthesizes personalized voice content by a multi-modal content generation unit for broadcasting. The system realizes precise timing reminding by sensing the user state, and dynamically generates differentiated reminding content based on the personalized portrait, effectively alleviating reminding fatigue, improving the acceptance of reminding and the efficiency of medication compliance management.

The cataract visual function inspection lamp comprises a lens body, a holding assembly, a stabilizing assembly and a light supplementing assembly, the lens body is composed of a shell of an annular structure, the holding assembly is composed of a handle, the handle is fixedly connected to the bottom of the shell, a pull-down mechanism is fixedly connected to the side wall of the top of a sliding cover, and the stabilizing assembly is composed of a vertical rod. The vertical rod is fixedly connected with the top of the shell, an adjusting seat is slidably connected into the vertical rod, one end of the adjusting seat is movably connected with a contact mechanism, and a limiting mechanism side is arranged on one side of the adjusting seat. The portable inspection lamp is used for visual function inspection of a cataract patient, the floodlight is used for light source irradiation, high-intensity light irradiation is achieved through the lamp body, the inspection lamp can be properly used according to different disease degrees of the patient, the angle of the lamp body is convenient to adjust, the angle of the light source is adjusted through the rotatable reflecting mirror, and the inspection effect is good. During examination, the contact block is pulled to move downwards, so that the eyes of the patient are opened for examination, and the multifunctionality of the examination lamp is improved.