High resolution fundus oculi vascellum flow velocity measuring system and measuring method

Abstract

The invention relates to a measurement system and a method for detecting ocular fundus blood flow velocity with high resolution. The measurement system is characterized in that a bacon light source is focused on the fundus by a human eye through a plurality of optical components to form a bacon spot; the spot is transformed into parallel light through the eye after backward reflection, and reaches a wavefront sensor through a wavefront phase corrector and a series of optical components to realize the process of self adaptive aberration correction; the imaging light source is focused on the front focus of the eye through the optical components, and is collimated by the eye into the parallel light to illuminate the retinal vascular microcirculation system; a laser speckle interferometry is formed on the surfaces of the fundus blood vessels illuminated; the interference field enters into wavefront phase corrector through the optical components and is reflected and finally focused on a photodetector through the series of optical components; a light speckle imaging process is realized. The measurement method has the advantage of enabling the whole system to overcome negative influences from the aberration of human eyes on capturing laser speckle interference field images, thus facilitating to obtain fundus velocity graph of high precision and resolution.

Description

technical field [0001] The invention belongs to the technical field of medical equipment manufacturing for retinal imaging of the human eye, and relates to a measurement method for a high-resolution fundus blood vessel flow velocity measurement system. Background technique [0002] Blood vessels are the most important metabolic channel of the human body. The disorder of the blood circulation system will inevitably lead to various diseases in the human body. Therefore, the detection of various functions of blood vessels has always been an important content of scientific research, and the monitoring of blood flow velocity is even more important. It is one of the long-term hot spots in the field of life science research. [0003] Currently, there are three common in vivo blood flow velocimetry techniques: image processing-based velocimetry, laser Doppler technology, and laser speckle velocimetry; image-processing-based velocimetry is the earliest and simplest method. This meth...

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the technical defects in the existing laser speckle velocimetry technology, such as intrusive, unable to observe for a long time, unable to use with the human body and other technical defects, as well as the common low resolution phenomenon in the existing ophthalmic imaging system ; A high-resolution fundus vascular flow velocity measurement system is proposed, which can organically combine two advanced technologies of laser speckle velocimetry and adaptive optics, overcome the influence of dynamic aberrations on the wide-beam illumination imaging of the human eye, and realize microscopic fundus imaging. In vivo long-term, high-resolution flow measurement of the circulatory system

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