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Nose cavity administering formulation of gastrodine

A nasal administration preparation and a technique for intranasal administration, which are applied in the field of gastrodin nasal administration preparations and can solve the problems of increasing patient pain and the like

Inactive Publication Date: 2007-02-07
ZHEJIANG ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although animal toxicity tests show that the toxicity of gastrodin is relatively low, frequent injections will increase the pain of patients, and there will be nausea and other gastrointestinal side effects when oral administration is large.

Method used

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  • Nose cavity administering formulation of gastrodine
  • Nose cavity administering formulation of gastrodine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Gastrodin 30g

[0026] borneol 0.3g

[0027] Hydroxypropyl Beta Cyclodextrin 6g

[0028] Distilled water up to 100ml

[0029] Preparation method: Put borneol and β-cyclodextrin in water, dissolve them with ultrasonic waves, and then dissolve gastrodin in the above solution to obtain the product.

[0030] Rats were anesthetized, tracheal intubation, esophageal ligation, put on a stereotaxic instrument, maintained body temperature at 37°C with a heating pad, trimmed and disinfected the head and neck, made a longitudinal incision along the longitudinal axis with a scalpel, and bluntly separated the neck with scissors Dorsal muscles, exposing the foramen magnum. According to the weight of the rat, insert the sampling needle from the foramen magnum into the cerebellar cisterna magna to collect the cerebrospinal fluid. After the cerebrospinal fluid can flow out due to the difference in internal and external pressure, fix the sampling needle with glue, turn the rat over, an...

Embodiment 2

[0036] Gastrodin 9g

[0037] Polysaccharide gellan gum 0.03g

[0038] Ethylparaben 0.02g

[0039] Distilled water up to 30ml

[0040] Preparation method: Swell gellan gum in distilled water, then add gastrodin, mix well, put it into a nasal sprayer, spray 70 μl each time, and spray once in each of the left and right nostrils.

Embodiment 3

[0042] Gastrodin 15g

[0043] Glyceryl monostearate 7g

[0044] Stearic acid 10g

[0045] White Vaseline 6g

[0046] Liquid paraffin 40ml

[0047] ice flakes 2g

[0048] Sodium Lauryl Sulfate 1g

[0049] Ethylparaben 0.1g

[0050] Distilled water 30ml

[0051] Preparation method: Take glyceryl stearate, stearic acid, white vaseline and liquid paraffin and heat and melt to form an oil phase. Add borneol to the oil phase to dissolve. In addition, distilled water was heated to 80°C, sodium lauryl sulfate and ethyl paraben were added to dissolve, and then gastrodin was added to dissolve into an aqueous phase. Then slowly pour the water phase into the oil phase and stir until it condenses.

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PUM

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Abstract

The invention discloses a gastrodine nasal administer drug agent to treat nervous prostration and vascular dementia, which is characterized by the following: adopting gastrodine as main raw material and certain effective drug as auxiliary material; resisting pain; modifying local brain blood flow; targeting brain through gastrodine.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, in particular to a gastrodin nasal administration preparation for treating neurasthenia, neurasthenia syndrome, vertigo, headache and vascular dementia. Background technique [0002] The brain is a delicate organ in the human body. Drugs must cross the blood-brain barrier to enter the brain tissue and exert their curative effect. The blood-brain barrier is mainly composed of brain capillary endothelial cells tightly combined, and all capillary endothelial cells are arranged in a tightly combined form, and there is no gap at the junction of cells. In addition, there is an efflux pump system on the endothelial cells, such as P-glycoprotein, which pumps the incoming substances back into the blood vessels under the action of ATPase, preventing them from entering the brain tissue. The blood-brain barrier provides a relatively stable internal environment for brain tissue and ensures the normal functio...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P25/04A61P25/20A61P25/28
Inventor 王俏陈国神
Owner ZHEJIANG ACAD OF MEDICAL SCI
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