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Preparation method of hollow fiber used for blood vessel tissue engineering

A tissue engineering and hollow technology, applied in hollow filament manufacturing, fiber processing, fiber chemical characteristics, etc., can solve the problems of poor mechanical properties of hollow fibers, poor cell adhesion and proliferation properties, etc., to enhance adhesion and effect of proliferation

Inactive Publication Date: 2014-03-19
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Abstract
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Problems solved by technology

However, the mechanical properties of PLGA hollow fibers are not good, and the cell adhesion and proliferation properties are not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] (1) Preparation of polymer solution: the mixture of PCL (molecular weight 60kDa) and PLGA (molecular weight 100kDa, molecular ratio of DL-lactide and caprolactide is 50 / 50) is dissolved in N-methylpyrrolidone to prepare a polymer The solution is stirred at 50-60° C. for 12-18 hours, and finally the polymer solution is filtered with a 15 μm metal sieve under a pressure of 0.4-0.6 bar, and then exhausted for 48 hours before hollow fiber spinning.

[0011] (2) Preparation of hollow fiber: the temperature of the solution in the syringe is kept at 30°C except for pure PLGA, and other polymer solutions are kept at 45°C, extruded through a spinneret with an outer diameter of 1.6mm and an inner diameter of 0.7mm; distilled water As the liquid phase, ethanol is used as the non-solvent phase in the coagulation bath. The temperature of distilled water and ethanol in the coagulation bath is controlled at 30 ° C. The hollow fiber is immersed in another ethanol coagulation bath for 24...

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Abstract

The invention relates to a preparation method of a hollow fiber used for the tissue engineering. The hollow fiber is prepared through a phase transition of a PCL / PLGA mixture, has an appropriate tensile strength and can be used for a regeneration technology of blood vessels having small diameters. The hollow fiber can also be mixed and dissolved after processing, the obtained mixed and dissolved material has an appropriate mechanical properties for operation, and can satisfy the smallest mechanical demands of the blood vessels having small diameters. The hollow fiber has a wide application prospect in the tissue engineering field because of its excellent performances.

Description

technical field [0001] The invention relates to the preparation of a hollow fiber for tissue engineering, in particular to a preparation method of a hollow fiber based on polylactide-copolyglycolide and polyε-caprolactone mixture. Background technique [0002] Large and medium-diameter blood vessels for tissue engineering have been replaced by permanent artificial vascular grafts. However, the preparation of small-diameter vascular grafts (<6nm) faces great challenges, and cell / tissue homogeneous arteries are still In use, although this type of artery has many shortcomings, such as unsound donors and poor quality, etc., the swelling of the intima and the formation of thrombus make most of the implantation of small-diameter blood vessels for tissue engineering fail. Therefore, there is still a strong clinical need for the preparation of multifunctional small-diameter vascular grafts. [0003] Recent research has begun to prepare tubular scaffold materials with suitable st...

Claims

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Application Information

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IPC IPC(8): A61L27/26D01F8/14D01D1/02D01D1/10D01D5/24
Inventor 韩志超许杉杉佴刚
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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