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Preparation method of conjugate electrospinning nanofiber artificial small-caliber intravascular stent and product

A technology of electrospinning nanofibers and vascular stents, which is used in textiles and papermaking, food packaging, pharmaceutical packaging, etc. Stenosis and other problems, to achieve the effect of simple and effective patency rate, good biocompatibility, and good mechanical properties

Active Publication Date: 2020-10-30
无锡市觉新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And there are many artificial small blood vessels due to the material properties, so that the inner wall of the artificial small-caliber blood vessels cannot be quickly endothelialized, which causes the excessive proliferation of smooth muscle cells, which makes the artificial small-caliber blood vessels restenosis and reduces the patency rate.
The problems of artificial blood vessels in clinical practice are still not fully resolved

Method used

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  • Preparation method of conjugate electrospinning nanofiber artificial small-caliber intravascular stent and product
  • Preparation method of conjugate electrospinning nanofiber artificial small-caliber intravascular stent and product
  • Preparation method of conjugate electrospinning nanofiber artificial small-caliber intravascular stent and product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) To prepare a silk fibroin solution, dissolve the silk fibroin in purified water at room temperature with a silk fibroin concentration of 10%, and stir for 1 hour to ensure that the silk fibroin is fully dissolved.

[0021] (2) Add PEO to the silk fibroin solution, the concentration is 1%, and the ratio of PEO to silk fibroin is 1:10

[0022] (3) Prepare silk fibroin and heparin mixed spinning solution, dissolve heparin in the prepared PEO-silk fibroin solution, the heparin concentration is 1%.

[0023] (4) Prepare PLCL spinning solution, dissolve lactide-caprolactone copolymer PLCL in hexafluoroisopropanol HFIP at a concentration of 8%.

[0024] (5) Prepare silk fibroin and PLCL nanofiber artificial small-caliber vascular stent by conjugate electrospinning technology, the voltage of PLCL nanofiber spinning is 10kV, the solution flow rate is 1.0ML / h, and the voltage of silk fibroin nanofiber spinning is 10kV, the solution flow rate is 0.8ML / h.

[0025] (6) The rece...

Embodiment 2

[0028] (1) To prepare a silk fibroin solution, dissolve the silk fibroin in purified water at room temperature with a silk fibroin concentration of 20%, and stir for 1 hour to ensure that the silk fibroin is fully dissolved.

[0029] (2) Add PEO to the silk fibroin solution, the concentration is 2%, and the ratio of PEO to silk fibroin is 1:10

[0030] (3) Prepare silk fibroin and heparin mixed spinning solution, dissolve heparin in the prepared PEO-silk fibroin solution, the heparin concentration is 3%.

[0031] (4) Prepare PLCL spinning solution, dissolve lactide-caprolactone copolymer PLCL in hexafluoroisopropanol HFIP at a concentration of 10%.

[0032] (5) Prepare silk fibroin and PLCL nanofiber artificial small-caliber vascular stent by conjugate electrospinning technology, the voltage of PLCL nanofiber spinning is 15kV, the solution flow rate is 1.0ML / h, and the voltage of silk fibroin nanofiber spinning is 15kV, the solution flow rate is 1.2ML / h.

[0033] (6) The rot...

Embodiment 3

[0036] (1) To prepare a silk fibroin solution, dissolve the silk fibroin in purified water at room temperature with a silk fibroin concentration of 15%, and stir for 1 hour to ensure that the silk fibroin is fully dissolved.

[0037] (2) Add PEO to the silk fibroin solution, the concentration is 1.5%, and the ratio of PEO to silk fibroin is 1:10

[0038] (3) Prepare silk fibroin and heparin mixed spinning solution, dissolve heparin in the prepared PEO-silk fibroin solution, the heparin concentration is 3%.

[0039] (4) Prepare PLCL spinning solution, dissolve lactide-caprolactone copolymer PLCL in hexafluoroisopropanol HFIP at a concentration of 9%.

[0040] (5) Prepare silk fibroin and PLCL nanofiber artificial small-diameter vascular stent by conjugate electrospinning technology, the voltage of PLCL nanofiber spinning is 12kV, the solution flow rate is 1.0ML / h, and the voltage of silk fibroin nanofiber spinning is 12kV, the solution flow rate is 1.0ML / h.

[0041] (6) The rot...

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Abstract

The invention discloses a preparation method of a conjugate electrospinning nanofiber artificial small-caliber intravascular stent. The preparation method comprises the following steps that S1, a fibroin and heparin mixed spinning solution is prepared; S2, a lactide-polycaprolactone copolymer (PLCL) spinning solution is prepared; and S3, the fibroin and PLCL nanofiber artificial small-caliber intravascular stent is prepared through the conjugate electrospinning technology, and the conjugate electrospinning nanofiber artificial small-caliber intravascular stent is obtained by adjusting the flowspeed ratio of the fibroin and heparin mixed spinning solution and the lactide-polycaprolactone copolymer spinning solution and the rotating speed of a spinning receiver. The method for preparing theconjugate electrospinning nanofiber artificial small-caliber intravascular stent is simple and efficient in operation and low in price; the small-caliber intravascular stent has good mechanical properties and biocompatibility; and compared with a nanofiber stent prepared by a common electrospinning method, the small-diameter intravascular stent has larger porosity, cells can be migrated into thestent more easily, tissue regeneration is promoted, and the stent has extremely good application prospects in vascular tissue engineering.

Description

technical field [0001] The invention relates to the field of medical device preparation, in particular to a method for preparing a conjugated electrospun nanofiber artificial small-diameter vascular stent, and also to a product prepared by the method. Background technique [0002] Vascular diseases such as coronary heart disease and peripheral vascular disease have become a serious human health problem. Stent implantation and vascular grafting are currently the most effective methods for treating vascular diseases. According to statistics, more than 10 million cases of vascular surgery have been completed worldwide, but the number of autologous blood vessels is limited, the matching performance of allogeneic blood vessels is poor, and it is easy to cause rejection. Therefore, the development and research of artificial blood vessels is of great significance. Artificial blood vessels with a caliber larger than 6mm have been able to achieve stable long-term patency, while smal...

Claims

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Application Information

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IPC IPC(8): D04H1/435D04H1/728D04H1/76A61L31/06A61L31/04A61L31/16A61L33/10
CPCD04H1/435D04H1/728D04H1/76A61L31/041A61L31/16A61L33/0011A61L33/08A61L2300/232A61L2300/42A61L2300/604A61L2400/12C08L89/00C08L67/04C08L71/02C08L5/10
Inventor 匡海珠张鹏曹伟灵
Owner 无锡市觉新生物科技有限公司
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