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Nanofiber jointly modified by SAB and heparin and preparation and application thereof

A nanofiber and fiber technology, which is applied in the chemical characteristics of fibers, cellulose/protein conjugated rayon, and rayon manufacturing, etc., can solve the problems of rapid endothelialization and acute thrombosis in the inner wall of blood vessels.

Inactive Publication Date: 2019-11-05
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a nanofiber co-modified by SAB and heparin and its preparation and application, so as to overcome the defects of acute thrombus and the inability of rapid endothelialization of the inner wall of the blood vessel in the prior art when small-caliber blood vessels are implanted in the human body

Method used

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  • Nanofiber jointly modified by SAB and heparin and preparation and application thereof
  • Nanofiber jointly modified by SAB and heparin and preparation and application thereof
  • Nanofiber jointly modified by SAB and heparin and preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] (1) To prepare SAB-MSN, dissolve SAB in ethanol at room temperature at a concentration of 4mg / ml, then disperse mesoporous nanosilicon (MSN) in the prepared SAB solution at a concentration of 4mg / ml, and ultrasonically MSN is evenly dispersed. After the mixture of SAB and MSN was stirred at room temperature for 24 hours, the precipitate SAB-MSN was obtained by centrifugation at 13,000 rpm for 30 minutes.

[0029] (2) Prepare the shell spinning solution, disperse the SAB-MSN in the HFIP in the step (1), the concentration is 2mg / ml, and then treat it with ultrasonic vibration for 30 minutes to ensure uniform dispersion to obtain the SAB-MSN dispersion solution; 0.8 g of PLCL and 0.2 g of collagen were dissolved in 10 mL of the SAB-MSN dispersion solution to obtain a shell spinning solution.

[0030] (3) Prepare nanofibers, dissolve heparin in RO water, and the mass fraction of heparin is 15%, to obtain a core layer solution, which is prepared by coaxial electrospinning t...

Embodiment 2

[0035] According to Example 1, in the step (3) of Example 1, "dissolve heparin in RO water, and the mass fraction of heparin is 15%" is changed to "dissolve heparin in RO water, and the mass fraction of heparin is 10%", and the rest are the same as Same as in Example 1, nanofibers co-modified with SAB and heparin were obtained as the inner layer of the stent.

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Abstract

The invention relates to a nanofiber jointly modified by SAB and heparin and preparation and application thereof. The fiber comprises a shell layer which comprises SAB-MSN and a high molecular polymer, and a core layer which comprises the heparin. The method comprises the steps of preparation of SAB-MSN, preparation of a shell layer spinning solution, preparation of a core layer solution and preparation of the nanofiber. The method is simple and efficient, and the price is low. The core layer and the shell layer of the nanofiber carry drugs simultaneously, and the double sustained release effect can be achieved; the good biocompatibility and blood compatibility are achieved, and the nanofiber has excellent application prospects in vascular tissue engineering.

Description

technical field [0001] The invention belongs to the field of artificial blood vessel materials and their preparation and application, in particular to a nanofiber modified with SAB and heparin and its preparation and application. Background technique [0002] Coronary heart disease and peripheral vascular disease have become a serious burden on human health. According to statistics, there have been about 10 million cases of vascular surgery worldwide. Autologous and allogeneic blood vessel transplantation cannot provide enough blood vessels to be implanted in the human body. Therefore, research on artificial small blood vessels has important clinical significance. In the early stage after the artificial small blood vessel is transplanted into the animal model, strong anticoagulant function is required to prevent the occurrence of acute thrombosis, and at the same time, it is necessary to promote the rapid growth and proliferation of endothelial cells and migrate in the inner...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/02D01F8/14D01F1/10A61L27/50A61L27/02A61L27/18A61L27/24A61L27/20
CPCA61L27/025A61L27/18A61L27/20A61L27/24A61L27/507A61L2400/12D01F1/10D01F8/02D01F8/14C08L67/04C08L5/10
Inventor 莫秀梅匡海珠陆树洋王尧石宇
Owner DONGHUA UNIV
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