42 results about "Triple combination" patented technology

There is provided an extended release pharmaceutical composition comprising from about 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also provides an extended release pharmaceutical composition comprising triple combination of from about 30 mg to about 300 mg of levodopa, 10 mg to about 100 mg of carbidopa and 200 mg to about 1000 mg of entacapone or salts thereof, optionally with other pharmaceutically acceptable excipients. The invention also relates to process of preparation of such compositions.

The invention provides a technical proposal of a public key encryption and decryption method and belongs to a multivariate public key cryptographic system. The encryption is provided by triple combination of reversible linear transformation, reversible nonlinear transformation and reversible linear transformation, and only two reversible linear transformations are necessary to be mastered as a private key at decryption. The method is a substantial improvement of a Matsumoto-Imai cryptographic system, and the new proposal can help effectively resist attack methods such as differential attack, linearization attack and the like. The method also follows the advantages of high efficiency, no cryptographic processor, and being especially suitable for smart cards and the like of the multivariate public key cryptographic system. The advantages of the multivariate public key cryptographic system, particularly resistance of attacks by a quantum computer, can not be compared by those of the traditional public key cryptographic system. Once the quantum computer is practically used, the proposal can be used for replacing the traditional public key cryptographies such as RSA, ECC, ELGamal and the like. The invention further provides a safe and efficient digital signature method based on the public key encryption and decryption method.

The addition of a selective, fast-acting, short half-life CDK 4/6 inhibitor in a very specific dosage regimen to the combination of chemotherapy with a checkpoint inhibitor provides superior results in the treatment of a tumor or cancer. The unexpected discovery is that the short pulsatile specifically-timed administration of a selective, fast-acting, short half-life CDK 4/6 inhibitor during administration of the chemotherapy portion of the triple combination therapy has a profound effect on the immune cells in the cancer microenvironment.

In alternative embodiments, the invention provides a “triple combination” therapy for treating, ameliorating and preventing Crohn's Disease (or Crohn syndrome, terminal or distal ileitis or regional enteritis) or related disorders and conditions in mammals, such as paratuberculosis in mammals, or Johne's disease, including genetically-predisposed and chronic disorders, where the microbial or bacterial flora of the bowel is at least one causative or symptom-producing factor; and compositions for practicing same. In alternative embodiments, methods and compositions of the invention comprise or comprise use of therapies, medications, formulations and pharmaceuticals comprising active agents that can suppress or eradicate the microbiota super-infection that causes Crohn's Disease or paratuberculosis infection in mammals. In alternative embodiments, the methods and uses of the invention for treating, ameliorating and preventing Crohn's Disease and complications of Crohn's Disease, or related disorders and conditions in mammals, such as paratuberculosis in mammals, or Johne's disease, comprises administration to an individual (human or mammal) in need thereof: (1) an anti-TNFα composition, or a composition capable of down-modulating TNFα activity; (2) a Hyperbaric Oxygen Treatment, or HBOT; and (3) an anti-Mycobacterium avium sub species paratuberculosis (MAP) (an anti-MAP) agent, composition or therapy.

The invention discloses a human DC-CIK immunocompetent cell. The human DC-CIK immunocompetent cell is characterized by being loaded with the vaccine oncolytic gene virus Oncopox-IL-24, wherein the vaccine oncolytic gene virus Oncopox-IL-24 is obtained through fusion of the vaccine oncolytic virus and the IL-24 gene, the IL-24 gene is inserted into a TK enzyme gene region of the vaccine oncolytic virus, and the human DC-CIK immunocompetent cell is obtained through co-culture of the vaccine oncolytic gene virus Oncopox-IL-24 and a DC-CIK immunocompetent cell. The human DC-CIK immunocompetent cell combines the advantages of the oncolytic virus, cell factors and immune cells to realize an efficient broad-spectrum tumor killing effect through cooperation, the tumor cell killing activity of the human DC-CIK immunocompetent cell is over 160 times higher than that of DC-CIK, inhibition of a neutralizing antibody on tumor cell invasion of the oncolytic virus is avoided during blood circulation, the in-vivo curative effect of the oncolytic virus is improved, the side effect of the oncolytic virus is reduced, and a new direction is provided for developing efficient and safe clinical antitumor immunity cell therapy techniques or drugs.

The present invention relates to a method for treating metastatic breast cancer in an individual comprising administering to an individual in need thereof a dosing regimen which comprises administering to the individual nonpegylated liposomal doxorubicin, a taxane and a HER2/neu receptor antagonist, wherein the individual previously has been administered an anthracycline.

The invention discloses a flexible positioning mechanism for white vehicle body assembly welding. The mechanism comprises a base; a first cover plate is arranged on the surface of the base; a triple combination element is arranged in the first cover plate; a second cover plate is arranged beside the first cover plate; an electromagnetic valve is arranged in the second cover plate; an electric appliance signal module mounting bracket is mounted on the surface of the base; fixing mechanisms are uniformly distributed on the bottom surface; the fixing mechanisms comprise pressure bearing plates fixed through bolts; vertical support plates are arranged on the pressure bearing plates; support plates for supporting the base are arranged on one sides of the vertical support plates; the support plates are fixedly connected with the pressure bearing plates through bolts; a servo flexible positioning device is arranged on the surface of the base; a reciprocating rod mechanism is arranged at the middle part of the surface; and a vehicle body carrying flexible positioning mechanism is mounted on the reciprocating rod mechanism. Through support by the flexible positioning mechanism, the production efficiency is improved, the vehicle body welding position can be effectively fixed, and the carrying time is greatly shortened; and the mechanism has the characteristics of simple operation and good fixing effect.

The invention features new a method for treating inflammatory bowel disease, including Crohn's Disease (CD) or ulcerative colitis in a human patient, comprising administering to a patient a combination therapy comprising an anti-α4β7 antibody, a TNFα antagonist, and an immunomodulator.

The invention discloses a non-oil-stick triple-combination piston oil ring and a fabrication method thereof. The surfaces of a bushing ring and a scraper are subjected to ultrasonic cleaning and then phosphating; a thin phosphate layer is formed on the surface of a ring body; then, a non-oil-stick coating is sprayed; and a dense non-oil-stick coating is formed on the surface of the bushing ring and the scraper by drying and solidifying. The non-oil-stick coating consists of molybdenum disulfide and polytetrafluoroethylene; after the non-oil-stick coating is sprayed on the surface or the surfaces of the bushing ring or the bushing ring and the scraper, the liquidity of lubricating oil on the surface of the ring body is improved, the problem that carbon is easily formed on the surface of the existing triple-combination oil ring to result in high oil consumption is solved, the oil consumption is lowered, and an engine can be energy-saving and environment-friendly truly.

The invention provides a wastewater reuse process and device. The wastewater reuse process comprises the following steps: S1, wastewater is fed into a triple-combination concentration tank; S2, flow-out wastewater enters a CMF (continuous membrane filtration) treatment system for primary filtering treatment; S3, wastewater collected in a CMF water production tank flows through an active carbon filter and a cartridge filter sequentially for secondary filtering treatment; S4, wastewater subjected to secondary filtering treatment is treated in a reverse osmosis device and flows into a reverse osmosis production tank. The wastewater reuse process and device have the following advantages: (1) a small area is occupied, civil engineering investment is small, and a high-density tank, a V-shaped filter tank and a middle water tank are not needed; (2) multi-media, ultrafiltration, matched equipment, chemicals and consumables are omitted, and the cost is lower; (3) reuse treatment of VRLA (valve-regulated lead-acid) battery wastewater is more targeted; (4) effluent is more stable and operation cost is lower by adopting the CMF treatment system instead.

The invention discloses an eyesight-improving paste formula used for myopia and a preparation method thereof. The eyesight-improving paste formula comprises the following components: 5 parts of safflower carthamus, 5 parts of raspberry, 5 parts of Semen Cuscutae, 5 parts of Radix Codonopsis, 5 parts of bighead atractylodes rhizome, 5 parts of cassia seed, 5 parts of Plantain seed, 5 parts of motherwort fruit, 4 parts of pearl, 4 parts of radix pseudostellariae, 5 parts of Radix Astragali, 1 part of Asarum Herb, 0.25 parts of borneol, 10 parts of edible ethanol with content concentration being95%, 0.25 parts of ethylparaben, and the balance of alkylene. Compared with current various myopia treatment modes in the prior art, the problems of long treatment course, slow effectiveness, impermanent effect, inconvenient usage and high technical requirement can be solved. A traditional traditional Chinese medicine is taken as a basis, modern science and technology is combined to prepare a paste agent, a triple combination therapy of acupoint drug application, massage and meridian treatment is used at a periorbital area, the eyesight-improving paste has the advantages of efficient and simple clinical effect, and the persistent effectiveness can be obviously improved.

The invention provides a frame, comprising a left-right floor beam double-combination part, a left-right front-floor rear-beam combination part, a rear floor beam double-combination part, a rear floor beam triple-combination part, a left-right rear girder seaming part and a front-floor left-right front carling seaming part, wherein the left-right floor beam double-combination part and the left-right front-floor rear-beam combination part are arranged in parallel and are respectively erected on the front-floor left-right front carling seaming part, and the rear floor beam double-combination part and the rear floor beam triple-combination part are arranged in parallel and are respectively erected on the left-right rear girder seaming part. The frame has the beneficial effects that strength and stiffness can be improved on the premise of light weight, and the cost is lowered.

The invention discloses a device for increasing the shale gas recovery rate by arc cylinder surface triple-combination energy-gathering fracturing. The device comprises a detonating device and a gas delivery device; the detonating device comprises a triple-combination energy-gathering device, a detonating circuit and an exploder; the triple-combination energy-gathering device comprises a left energy-gathering cover used for gathering explosive exploding energy to emit the energy to the right, a right energy-gathering cover used for gathering explosive exploding energy to emit the energy to theleft, and a middle energy-gathering cover used for gathering explosive exploding energy to emit the energy to the middle; and the left energy-gathering cover and the right energy-gathering cover arearranged to be rotating paraboloids with openings outwards, and the middle energy-gathering cover is arranged to be a cylinder surface with an opening outwards. Compared with the prior art, because ofthe energy-gathering effect of the left energy-gathering cover, the middle energy-gathering cover and the right energy-gathering cover, shale in a fracturing area can be pressed and exploded simultaneously from the three space directions of left, middle and right separately, cracks quickly penetrate to form a shale fracture zone shaped like a Chinese character ge, the superficial area the shale is increased, and therefore the analytical rate and recovery rate of shale gas are effectively increased. A spherical-crown-shaped boss further strengthens the energy-gathering effect.