The invention relates to a coking wastewater reuse treatment system. The system is characterized in that the system comprises a coagulation pool (1), and the coagulation pool (1) is sequentially connected with an inclined plate sedimentation pool (2), an ultrafiltration device (3), an ultrafiltration water production pool (5), a first pump (6), a first filter (7), a second filter (8), a second pump (9), a nanofiltration device (10), a nanofiltration water production pool (11), a third pump (12), a third filter (13), a reverse osmosis device (14) and a reverse osmosis water production pool (15) through a pipeline. The invention also provides a coking wastewater reuse treatment method. The system has the advantages of stable treatment effect, low production running cost, simple operation running, realization of the water discharge through adopting a biochemical sedimentation pool, avoiding of the physical-chemical treatment segment after routine biochemical treatment, avoiding of the massive application of agents, reduction of the sludge throughout of the system, and reduction of the wastewater treatment running cost.