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Probiotics and application thereof in secondary osteoporosis

An osteoporosis and secondary technology, applied in the field of microorganisms, can solve the problems of huge economic burden for patients, and achieve the effect of promoting bone formation in vivo and improving expression

Active Publication Date: 2020-09-04
安徽善和生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these drugs may have safety, tolerability and other issues, and bring huge economic burden to patients

Method used

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  • Probiotics and application thereof in secondary osteoporosis
  • Probiotics and application thereof in secondary osteoporosis
  • Probiotics and application thereof in secondary osteoporosis

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Experimental program
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Embodiment 1

[0024] 1. Materials and Methods

[0025] 1.1 Laboratory strain

[0026] Lactobacillus plantarum HFY15 was isolated from yak yogurt in Sichuan Province, China. It was identified as lactic acid bacteria, LAB by 16S rDNA sequence. Center (CGMCC for short, address: Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing), and the deposit registration number is CGMCC No.16648.

[0027] The Lactobacillus plantarum HFY15 isolated and purified from yak yoghurt samples showed positive Gram staining; the color of the colonies was mostly white or milky white, round in shape, with neat edges, and a moist and smooth surface. There are long rods, short rods, and spherical shapes, and there is no budding.

[0028] The 16S rDNA base sequence of the bacterial strain HFY15 of the present invention is shown in SEQ ID No.1; the sequencing results are compared on the NCBI website (http: / / blast.ncbi.nlm.nih.gov / Blast.cgi) . Same as La...

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Abstract

The invention discloses probiotics and application thereof in secondary osteoporosis, and belongs to the technical field of microorganisms. The lactobacillus plantarum HFY15 is lactic acid bacteria (LAB) with the preservation number of CGMCC No. 16648, and the Lactobacillus plantarum HFY15 is separated and identified from natural yak yoghourt. A rat secondary osteoporosis (OP) model is establishedby using retinoic acid, and prevention effect of the ahfy15 on the OP is researched; the results show that the supplement of the HFY15 increases the expression of osteogenic marker genes, inhibits the expression of osteoclast genes, and stimulates the formation of bones; and a research result provides a new effective strategy for prevention and treatment of OP.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a probiotic and its application in secondary osteoporosis. Background technique [0002] Secondary osteoporosis (OP) is caused by certain diseases and treatments that interfere with bone density and cause bone loss. Up to 30% of postmenopausal women and 50% of men may be at potential risk for osteoporosis. People with early osteoporosis generally do not experience symptoms, and osteoporosis often goes undetected for years until a person breaks a bone and is not diagnosed. Common fractures associated with osteoporosis include fractures of the hip, wrist, or spine. Osteoporosis occasionally causes symptoms, and the underlying pathogenesis of secondary osteoporosis is often multifactorial. Properly treating osteoporosis can reduce the risk of fractures and prevent unnecessary treatment with antiresorptive drugs. [0003] Many diseases, drugs, and lifestyle factors can cau...

Claims

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Application Information

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IPC IPC(8): C12N1/20A61K35/747A61P19/10C12R1/25
CPCC12N1/20A61K35/747A61P19/10C12R2001/25C12N1/205Y02A50/30
Inventor 赵欣刘新红
Owner 安徽善和生物科技有限公司
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