52 results about "Benzoate derivative" patented technology

Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.

The invention relates to an indoleamine2,3-dioxygenase inhibitor having a structure as shown in a formula (I), as well as a preparation method and application thereof. The IDO inhibitor is (Z)-N'-hydroxyl-N-benzoate derivative, has high inhibiting activity for IDO, can be used for effectively inhibiting the IDO activity and inhibiting immunosuppression of patients, can be widely applied to treatment or prevention of cancer or tumors, virus infection, depression, neural degeneration disease, trauma, age related cataract, organ transplant rejection or autoimmune disease, and is expected to be developed into a new generation of immunosuppressors.

The present invention relates to solid catalyst components comprising titanium, magnesium, halogen and an internal electron donor compound containing at least one 1,8-naphthyl diester compound. The 1,8-naphthyl diester compounds include naphthalene-1,8-diyl dicycloalkanecarboxylate derivatives, dicycloalkenecarboxylate derivatives, 8-(cycloalkanecarbonyloxy)naphthalene-1-yl benzoate derivatives, and 8-(cycloalkenecarbonyloxy)naphthalene-1-yl benzoate derivatives. The present invention further relates to catalyst systems containing the catalyst solid components, organoaluminum compounds, and organosilicon compounds. The present invention also relates to methods of making the solid catalyst components and the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.

The present invention relates to catalyst systems containing solid catalyst components comprising titanium, magnesium, halogen and an internal electron donor compound having at least one ether group and at least one ketone group; organoaluminum compounds and alkyl benzoate derivatives as external electron donors. The present invention also relates to methods of making the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.

The present invention relates to solid catalyst components comprising titanium, magnesium, halogen and an internal electron donor compound containing at least one 1,8-naphthyl diester compound. The 1,8-naphthyl diester compounds include naphthalene-1,8-diyl dicycloalkanecarboxylate derivatives, dicycloalkenecarboxylate derivatives, 8-(cycloalkanecarbonyloxy)naphthalene-1-yl benzoate derivatives, and 8-(cycloalkenecarbonyloxy)naphthalene-1-yl benzoate derivatives. The present invention further relates to catalyst systems containing the catalyst solid components, organoaluminum compounds, and organosilicon compounds. The present invention also relates to methods of making the solid catalyst components and the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.

The present invention relates to catalyst systems containing solid catalyst components comprising titanium, magnesium, halogen and a 1,8-naphthyl diaryloate internal electron donor compound; organoaluminum compounds and alkyl benzoate derivatives as external electron donors. The present invention also relates to methods of making the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.

The invention provides benzoate derivatives. A series of benzoate derivatives are synthesized through a chemical method, comprising ester compounds, (sulfur) ether compounds and amide compounds, wherein most synthesized compounds have new chemical structures, and proved through in vitro cell activity experiments, the synthesized benzoate derivatives have obvious activities similar to nerve growth factors (NGF). Proved through an in vitro animal experiment, 2,3-dyhydroxy benzoic acid tetradecyl ester which is a new synthesized compound has the effect of enhancing the memory of senile mice, thus the benzoate derivative can be applied to preparing medicaments for preventing and treating senile dementia neurodegenerative diseases, particularly to preparing medicaments for treating the neurodegenerative diseases such as the Alzheimer's diseases (AD), and the like. The invention opens up a new medical application of the benzoate derivatives, has reasonable preparation method and simple and convenient operation and provides new treatment medicaments for preventing and treating the neurodegenerative diseases such as the senile dementia, and the like.

The present invention relates to catalyst systems containing solid catalyst components comprising titanium, magnesium, halogen and a 1,8-naphthyl diaryloate internal electron donor compound; organoaluminum compounds and alkyl benzoate derivatives as external electron donors. The present invention also relates to methods of making the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.

The invention discloses an isotretinoin amido alkyl benzoate derivative, a preparation method thereof and applications thereof. The derivative has stronger inhibition and differentiation regulating effects than isotretinoin on psoriasis, acne and epithelial cell tumors including, but not limited to skin squamous epithelial cell carcinoma, stomach cancer, lung cancer, and cervical cancer; the derivative has less influence on normal tissue cells, has a certain targeting effect on inhibiting proliferating cells, and has very less side effects than isotretinoin; and the derivative has wide promising prophylaxis and treatment applications such as cornification abnormality diseases and cell abnormal proliferation including tumors, psoriasis, acne, and other cornification abnormality dermatopathy.

The invention discloses a method for synthesizing dual-esterified 3,4,5-trihydroxybenzoxy bagasse xylan benzoate. The method comprises the steps: subjecting 3,4,5-triacetyl benzoyl chloride, which isproduced through subjecting 3,4,5-trihydroxybenzoic acid to acetylation and acyl chlorination and serves as an esterifying agent, to an esterification reaction with bagasse xylan in a N,N-dimethylformamide solvent, so as to synthesize bagasse xylan 3,4,5-trihydroxy benzoate; then, carrying out a second-step esterification reaction by taking benzoic acid as an esterifying agent and triethylamine asa catalyst, and synthesizing a dual-esterified 3,4,5-trihydroxybenzoxy bagasse xylan benzoate derivative in a dichloromethane solvent. According to the method, on the basis of unique bioactivity of xylan esterified derivatives, through introducing two kinds of active groups, the product has the advantages that the bioactivity of xylan is improved, and meanwhile, the range of application of the xylan derivatives in the fields of medicine, biology, functional materials and the like is widened.

The invention provides a process for continuously producing an aminobenzoate derivative, and a synthesis system thereof. The process comprises: putting a nitrobenzoic acid derivative, ethanol and a first catalyst into an esterification reaction device, and reacting for 1-1.5 h at a temperature of 70-75 DEG C; supplementing a nitrobenzoic acid derivatives, ethanol and a first catalyst into the esterification reaction device; making the liquid in the esterification reaction device flow into a dehydration esterification kettle; heating to azeotrope the ethanol-water in the dehydration esterification kettle, evaporating the azeotrope out of the dehydration esterification kettle, collecting the azeotrope, and discharging the liquid in the dehydration esterification kettle into a middle liquid storage groove; and making the liquid in the middle liquid storage groove flow into a hydrogenation reaction device, and carrying out a hydrogenation reaction under the action of a second catalyst at areaction temperature of 100-120 DEG C to obtain the product, wherein the pressure is kept at 0.6-1 Mpa. According to the invention, the process has advantages of continuous production and the like.

The present invention relates to a polymer composition comprising a heterophasic propylene copolymer, a mineral filler and a light stabilizers comprising a fatty acid derivative and a benzoate derivative. The polymer composition according to the present invention is applicable for automotive articles whereupon the undesired effect of stickiness is reduced significantly compared to automotive articles comprising conventional light stabilizers.

The invention relates to a method for preparing a drug Roflumilast for treating the chronic obstructive pulmonary disease. The Chinese chemical name of the drug Roflumilast is 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide. According to the method, in a process route, a dihydroxyl-substituted benzoate derivative, which can be extensively obtained, is adopted as a starting raw material, so that the consumption of noble metal catalysts is avoided, the synthesis process route is shortened, and the production cost is reduced greatly; through introducing difluoromethoxy by replacing a gaseous reagent with a solid difluoromethyl etherification reagent, which is safe, efficient, cheap and readily available, side reactions are reduced, and the selectivity of the reaction is improved; and the target product is obtained efficiently through condensing carboxyl groups and amino groups.

The uses of benzoate and its derivatives for anti-aging of brain, and for preventing and treating the neurodegenerative diseases such as the senile dementia and the like are provided in the present invention. A series of benzoate and its derivatives are synthesized through a chemical method in the present invention. Proved through cell activity experiments in vitro, the synthesized benzoate and its derivatives have distinguished activities similar to nerve growth factors. Proved through an animal experiment, benzoate and its derivatives do not induce toxic reaction during long term oral or celiac administration, they are able to cross the blood-brain barrier and promote the regeneration of cerebral neuron.

The invention discloses an isotretinoin amido alkyl benzoate derivative, a preparation method thereof and applications thereof. The derivative has stronger inhibition and differentiation regulating effects than isotretinoin on psoriasis, acne and epithelial cell tumors including, but not limited to skin squamous epithelial cell carcinoma, stomach cancer, lung cancer, and cervical cancer; the derivative has less influence on normal tissue cells, has a certain targeting effect on inhibiting proliferating cells, and has very less side effects than isotretinoin; and the derivative has wide promising prophylaxis and treatment applications such as cornification abnormality diseases and cell abnormal proliferation including tumors, psoriasis, acne, and other cornification abnormality dermatopathy.

The invention discloses a chemical synthesis method for 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one derivatives. The synthesis method of the invention includes: reacting a substituted ortho-halo benzoic acid as a raw material with an alcohol to obtain corresponding substituted acid ester; reacting with acrylonitrile to obtain a 2-(2'-cyano-alkenyl)benzoate derivative intermediate; and conducting a ring-closure reaction in the presence of alkoxide to obtain the 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one derivative. The method has the advantages of fewer reaction steps and high yield.

The invention provides a 4-formaldoxime benzoate derivative preparation method. The method mainly includes steps: dissolving 4-cyanobenzoate derivatives and hydroxylamine hydrochloride into an alcohol solvent, adding an appropriate amount of alkali, and performing reflux reaction to obtain a target product 4-formaldoxime benzoate derivative. According to the method, cyano compounds are adopted to directly obtain oxime compounds through one-step reaction. The method has advantages of mild reaction conditions, simplicity in operation, low cost, high product yield, high purity and the like and is suitable for large-scale production.

To provide a method for producing 4-ketobenzamide derivatives and 4-ketobenzoic acid derivatives.SOLUTION: The present invention provides a method for producing a 4-ketobenzamide compound represented by formula (2), by amidating a compound represented by formula (1), which is obtained through cyanation of a compound represented by formula (3), as well as a method for producing a 4-ketobenzoic acid derivative represented by formula (6), by hydrolyzing the compound represented by formula (1) or the compound represented by formula (2), and a method for producing a 4-ketobenzoic acid ester derivative represented by formula (5), by esterifying the compound represented by formula (2), wherein R1 represents a C1-C6 alkyl group or the like, R2 represents a C1-C6 alkyl group or the like, R3 represents a C1-C6 alkyl group or the like, X represents a halogen atom or the like, Y represents a C1-C6 alkyl group or the like, and n represents an integer of 0-3.SELECTED DRAWING: None

The present invention provides a novel process for the preparation of alkyl (1-alkylindol-3-ylmethyl)benzoate derivatives which process comprises the steps of: (a) reacting of an alkyl (halomethyl)benzoate with excess of an indole, said indole being unsubstituted at positions 1-, 2- and 3-, under conditions promoting alkylation at the 3-position of the indole to yield a mixture comprising alkyl (indol-3-ylmethyl)benzoate and unreacted starting indole, (b) treating the mixture obtained in step (a) with base to yield a mixture, comprising the salt of (indol-3-ylmethyl)benzoic acid and the unreacted indole, (c) recovering the unreacted indole from the mixture obtained in step (b), and recycling the indole as starting material to step (a), (d) isolating the salt of (indol-3-ylmethyl)benzoic acid and / or acidifying the salt to form (indol-3-ylmethyl)benzoic acid, (e) reacting the (indol-3-ylmethyl)benzoic acid or it's salt with alkylating agent in the presence of base to form the desired alkyl (1-alkylindol-3-ylmethyl)benzoate. The above process affords also the preparation of the anti-asthmatic leukotriene antagonist zafirlukast. In such case, methyl 3-methoxy-4-(1-methyl-5-nitroindol-3-ylmethyl)benzoate [a]is formed in step (e) of the process and this compound is subsequently converted into zafirlukast by known methods.

The invention provides a preparation method of a substituted benzoate derivative, which comprises the following steps: reacting zinc powder with a compound A in an organic solvent under the protection of inert gas to obtain a compound B containing a zinc reagent, coupling the compound B with a compound C under the action of a nickel catalyst and a metal Grignard reagent to generate a compound D, and separating the compound D from the compound C to obtain the substituted benzoate derivative. The method for preparing the final product is simple and efficient, the cost is reduced, and production is facilitated.

The invention discloses a detection reagent for detecting MHC-II expression of gastric cancer tissue tumor cells. The detection reagent comprises the following components in parts by mass: 10-30 parts of a paraffin section preparation solution, 2-10 parts of a dewaxing solution, 2-10 parts of a sodium citrate antigen repair solution and 20-40 parts of an immunohistochemical staining solution, the dewaxing liquid comprises xylene and at least one of a flavonol aminobenzoate derivative and erucyl amide benzoic acid benzyl trimethyl ammonium salt, the flavonol aminobenzoate derivative has a nitrogen-containing group and a benzene ring, and the erucyl amide benzoic acid benzyl trimethyl ammonium salt has long-chain unsaturated alkane and a nitrogen-containing group. The invention provides a detection reagent for detecting MHC-II expression of gastric cancer tissue tumor cells, and high-quality immunohistochemical staining sections can be obtained, so that the sensitivity and specificity of MHC-II expression detection are improved.

The reagent for detecting MHC-II expression of tumor cells in gastric cancer tissue comprises the following components in parts by mass: 10-30 parts of paraffin section preparation liquid, 2-10 parts of dewaxing liquid, 2-10 parts of sodium citrate antigen repair liquid, and 20-40 parts of immunohistochemical staining liquid; the dewaxing liquid comprises dimethylbenzene, and at least one of flavonol aminobenzoate derivative and sinapamide benzyl trimethylammonium benzoate salt; the flavonol aminobenzoate derivative has a nitrogen-containing group and a benzene ring, and the sinapamide benzyl trimethylammonium benzoate salt has a long-chain unsaturated alkane and a nitrogen-containing group. The reagent for detecting MHC-II expression of tumor cells in gastric cancer tissue can obtain high-quality immunohistochemical staining sections, thereby improving the sensitivity and specificity of MHC-II expression detection.

The invention provides an application of a 3-substituted-5-acylamino benzoate derivative shown in a formula (1) in preparation of drugs for treating acute lung injury and resisting inflammation. The invention discovers that the 3-substituted-5-acylamino benzoate derivative has the function of a P2Y14R antagonist for the first time, has an obvious antagonistic effect on P2Y14R related inflammation, and can be used for preparing the P2Y14R related anti-inflammatory drugs.

The invention relates to a compound as well as a synthesis method and application thereof. The invention provides a compound as shown in a formula 9 and a preparation method of a stereoisomer, a tautomer, a hydrate and a solvate of the compound, the structure of the compound has an electron-donating group, the hydrolysis of the compound can be inhibited, and the compound can be used for being combined with dNTP to form a reversible terminator and is used for nucleic acid sequencing. The synthesis method is high in atom economy, simple and convenient to operate, low in cost and easy to operate, greatly enriches the selection range of reaction substrates, can realize higher synthesis efficiency, and is beneficial to further modification and application of methyl-2-(1-(methyldisulfonyl) ethyl) benzoate derivatives. # imgabs0 #

The invention relates to the fields of natural medicines and medicinal chemistry, and relates to a heicogenin derivative as well as a preparation method and application thereof. The invention particularly relates to a preparation method for introducing amino acid, chlorambucil benzoate and chlorambucil butyrate derivatives at C3-OH sites of a heicogenin mother nucleus structure and application of the derivatives in preparation of anti-tumor drugs. The structure of the heicogenin spliced amino acid, chlorambucil benzoate and chlorambucil benzoate derivative and the pharmaceutically acceptable salt thereof is shown as a general formula I, II or III. Pharmacological experiments prove that the heicogenin derivative disclosed by the invention has a relatively good anti-tumor effect on human breast cancer cell lines and relatively low toxicity on human normal gastric mucosa epithelial cells GES-1, so that the heicogenin derivative has the potential of being developed into clinical anti-cancer drugs. # imgabs0 #

The present invention belongs to the technical field of chemical industry and pesticide, and specifically relates to a derivative containing N-phenylimine, a preparation method thereof and an application thereof. The present invention provides a derivative containing N-phenylimine, including: a 1,2,4-oxadiazole-N-phenylimine derivative with a structure shown in Formula 1, a 1,3,4-oxadiazole-N-phenylimine derivative with a structure shown in Formula 2, an N-phenylimine amide (ester) derivative with a structure shown in Formula 3 or an N-phenylimine benzoate derivative with a structure shown in Formula 4. The N-phenylimine derivative provided by the present invention has a 100% inhibitory effect on broad-leaved weeds at a dose of 10a.ig / mu, and even at a dose of 2.5aig / mu, some compounds still have a 100% inhibitory effect on broad-leaved weeds. The compound provided by the present invention can be developed and used as a potential PPO inhibitor and post-emergence herbicide for broad-leaved weeds. It has a simple structure and broad application prospects. #imgabs0#

A compound of the general formula (I) is provided for use in the topical treatment of infection, inflammation and / or pain: wherein R1 independently represents a methylene group, an ethylene group or a straight or branched chain C3 to C6 alkylene group; R2 independently represents a hydrogen atom, a methyl group, an ethyl group or a straight or branched chain C3 to C20 alkyl group; x represents 0 or an integer from 1 to 4 and y represents 0 or an integer from 1 to 4, wherein the sum of x and y is 4; and Z represents a hydrogen atom or (HOR1)yR2XN+; compositions including the compound; use of the compound in the manufacture of a medicament; and methods of medical treatment including the topical application of the compound.

The invention provides water-oil soluble o-(4-chloro) benzylthio-benzoate derivatives with plant growth-regulating activity and salts thereof. The derivatives are shown as a general formula (I, II), wherein X is an oxygen atom, a nitrogen atom or a sulfur atom; n is 0, 1, 2, 3, 4, 5 and so on or (CH2)n represents alkyl carrying a branched chain; Y is Cl<->, Br<->, F<->, I<->, AcO<->, acetylsalicylic acid radical, nitric acid radical, salicylic acid radical, p-toluenesulfonic acid radical, bisulfate radical or other negative ions; R<1> is alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, alkenyl of 1-6 carbon atoms, or aryl; R<2> is alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, alkenyl of 1-6 atoms, or aryl; or R<1> and R<2> are selected from the structure in the specification.