34 results about "Benzoate derivative" patented technology

Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.

The present invention relates to solid catalyst components comprising titanium, magnesium, halogen and an internal electron donor compound containing at least one 1,8-naphthyl diester compound. The 1,8-naphthyl diester compounds include naphthalene-1,8-diyl dicycloalkanecarboxylate derivatives, dicycloalkenecarboxylate derivatives, 8-(cycloalkanecarbonyloxy)naphthalene-1-yl benzoate derivatives, and 8-(cycloalkenecarbonyloxy)naphthalene-1-yl benzoate derivatives. The present invention further relates to catalyst systems containing the catalyst solid components, organoaluminum compounds, and organosilicon compounds. The present invention also relates to methods of making the solid catalyst components and the catalyst systems, and methods of polymerizing or copolymerizing alpha-olefins using the catalyst systems.

The invention discloses a method for synthesizing dual-esterified 3,4,5-trihydroxybenzoxy bagasse xylan benzoate. The method comprises the steps: subjecting 3,4,5-triacetyl benzoyl chloride, which isproduced through subjecting 3,4,5-trihydroxybenzoic acid to acetylation and acyl chlorination and serves as an esterifying agent, to an esterification reaction with bagasse xylan in a N,N-dimethylformamide solvent, so as to synthesize bagasse xylan 3,4,5-trihydroxy benzoate; then, carrying out a second-step esterification reaction by taking benzoic acid as an esterifying agent and triethylamine asa catalyst, and synthesizing a dual-esterified 3,4,5-trihydroxybenzoxy bagasse xylan benzoate derivative in a dichloromethane solvent. According to the method, on the basis of unique bioactivity of xylan esterified derivatives, through introducing two kinds of active groups, the product has the advantages that the bioactivity of xylan is improved, and meanwhile, the range of application of the xylan derivatives in the fields of medicine, biology, functional materials and the like is widened.

The invention provides a process for continuously producing an aminobenzoate derivative, and a synthesis system thereof. The process comprises: putting a nitrobenzoic acid derivative, ethanol and a first catalyst into an esterification reaction device, and reacting for 1-1.5 h at a temperature of 70-75 DEG C; supplementing a nitrobenzoic acid derivatives, ethanol and a first catalyst into the esterification reaction device; making the liquid in the esterification reaction device flow into a dehydration esterification kettle; heating to azeotrope the ethanol-water in the dehydration esterification kettle, evaporating the azeotrope out of the dehydration esterification kettle, collecting the azeotrope, and discharging the liquid in the dehydration esterification kettle into a middle liquid storage groove; and making the liquid in the middle liquid storage groove flow into a hydrogenation reaction device, and carrying out a hydrogenation reaction under the action of a second catalyst at areaction temperature of 100-120 DEG C to obtain the product, wherein the pressure is kept at 0.6-1 Mpa. According to the invention, the process has advantages of continuous production and the like.

The invention relates to a method for preparing a drug Roflumilast for treating the chronic obstructive pulmonary disease. The Chinese chemical name of the drug Roflumilast is 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide. According to the method, in a process route, a dihydroxyl-substituted benzoate derivative, which can be extensively obtained, is adopted as a starting raw material, so that the consumption of noble metal catalysts is avoided, the synthesis process route is shortened, and the production cost is reduced greatly; through introducing difluoromethoxy by replacing a gaseous reagent with a solid difluoromethyl etherification reagent, which is safe, efficient, cheap and readily available, side reactions are reduced, and the selectivity of the reaction is improved; and the target product is obtained efficiently through condensing carboxyl groups and amino groups.

The invention provides water-oil soluble o-(4-chloro) benzylthio-benzoate derivatives with plant growth-regulating activity and salts thereof. The derivatives are shown as a general formula (I, II), wherein X is an oxygen atom, a nitrogen atom or a sulfur atom; n is 0, 1, 2, 3, 4, 5 and so on or (CH2)n represents alkyl carrying a branched chain; Y is Cl<->, Br<->, F<->, I<->, AcO<->, acetylsalicylic acid radical, nitric acid radical, salicylic acid radical, p-toluenesulfonic acid radical, bisulfate radical or other negative ions; R<1> is alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, alkenyl of 1-6 carbon atoms, or aryl; R<2> is alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, alkenyl of 1-6 atoms, or aryl; or R<1> and R<2> are selected from the structure in the specification.

The invention relates to a liquid-crystalline medium, characterized in that it comprises one or more compounds of formula A and at least one compound of formula B, wherein R ^a , R ^b , Y, Z ¹ ,Z ² , L ¹ , L ² , L ³ , L ⁴ , L ⁵ , L ⁶ , L ⁷ and L ⁸ as defined in claim 1.

A compound of the general formula (I) is provided for use in the topical treatment of infection, inflammation and/or pain: wherein R¹ independently represents a methylene group, an ethylene group or a straight or branched chain C₃ to C₆ alkylene group; R² independently represents a hydrogen atom, a methyl group, an ethyl group or a straight or branched chain C₃ to C₂₀ alkyl group; x represents 0 or an integer from 1 to 4 and y represents 0 or an integer from 1 to 4, wherein the sum of x and y is 4; and Z represents a hydrogen atom or (HOR¹)_yR²_xN⁺; compositions including the compound; use of the compound in the manufacture of a medicament; and methods of medical treatment including the topical application of the compound.