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Compound used for treating acne and application thereof

A compound, acne technology, applied in the direction of hydroxy compound active ingredients, applications, cosmetics, etc., can solve problems such as skin redness, dryness and allergic reactions

Inactive Publication Date: 2016-08-17
LANHE SHANGHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such products may have side effects such as skin redness, dryness, and allergic reactions

Method used

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  • Compound used for treating acne and application thereof
  • Compound used for treating acne and application thereof
  • Compound used for treating acne and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] The preparation method of the compound represented by formula I can refer to the method described in the Chinese patent application CN200810041104.1.

[0050] Various terms used herein refer to various aspects of the present invention. To help illustrate the description of the components of the present invention, the following definitions are provided. Unless otherwise defined, all technical and scientific terms used herein have the meanings commonly understood by those skilled in the art to which the present invention belongs.

[0051] As used herein, the terms "compounds represented by formula I" and "compounds of the present invention" both refer to compounds having the structure represented by formula I.

[0052] As used herein, "about" will be understood by those skilled in the art and will vary to a certain degree in the context in which it is used. If there is a use of the term that is not clear to those skilled in the art in the context of the given term, "about" mea...

Embodiment 1

[0075] Example 1 Formulation of composition

[0076] Preparation of matrix liquid: 1 part by weight of carbomer 980NF, 5 parts by weight of glycerin, 5 parts by weight of propylene glycol, and 100 parts by weight of water. Different compositions were prepared in the matrix solution according to Table 1 for subsequent experiments.

[0077] Table 1

[0078] Group

[0079] A

Embodiment 2

[0080] Example 2 Anti-acne effect experiment

[0081] Method: Establishment of experimental animal model of acne. Reference 1: The effect of Qingre Anchuang tablets on anti-keratosis and hemorrheology of rabbit ear acne model. Gu Lizhen et al., Chinese Patent Medicine Journal.

[0082] The specific method is briefly described as follows:

[0083] Take New Zealand big-eared white rabbits and apply coal tar diluent (2% coal tar solution made up of 95% ethanol) to the opening of the inner ear tube of the right ear with a range of 2cm×2cm, 0.25ml once, for 14 days. Experimental animal model of acne.

[0084] On the 15th day, the four groups A-D of the composition and the control were respectively administered to the experimental animal model of acne for topical administration for 10 consecutive days. The effect of each group was observed by naked eye and microscope. According to the method in Literature 1, the five aspects of keratinization, the expansion of hair follicle pores, the amo...

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PUM

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Abstract

The invention discloses a compound used for treating acne and an application thereof. The compound has obvious effect for treating acne, and can alleviate side effect of retinoic acid by combining with retinoic acid.

Description

Technical field [0001] The present invention relates to the field of biotechnology, in particular to a compound for treating acne and its application. Background technique [0002] Acne is a disease or symptom that often occurs in adolescence. In mild cases, it will heal naturally. In severe cases, chemicals such as benzoyl peroxide, retinoids, antibiotics and antiandrogens are used to specifically or locally or Systemic treatment. However, such products may have side effects such as skin redness, dryness, and allergic reactions. [0003] The pathogenesis of acne is mediated by several factors. These factors include hyperproliferation and abnormal differentiation of keratinocytes, blocked hair follicles to form keratinaceous plugs, increased androgen and sebum production, and Propionibacterium acnes (Propionibacterium acnes). acnes) overgrowth and production of pro-inflammatory mediators. [0004] Those skilled in the art are committed to developing new acne treatment programs and...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61P17/10A61P17/08A61P17/00A61P1/02A23L1/30A61K8/49A61Q19/00A61Q11/00A61Q17/04A61Q1/12A61K31/203A61K31/05
Inventor 不公告发明人
Owner LANHE SHANGHAI BIOTECH CO LTD
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