9results about How to "Gentle preparation" patented technology

The invention discloses a pure physical cross-linked dual-temperature-sensitive hydrogel and a preparation method of the pure physical cross-linked dual-temperature-sensitive hydrogel. The hydrogel is composed of N-isopropylacrylamide, hydroxyl-containing cellulose, sodium pyrophosphate (Na4P2O7) and an initiator, a chemical cross-linking agent is not needed, and a dual physical cross-linked network is formed through combination of photo-initiation or thermal-initiation polymerization and heating induced phase transformation. The obtained hydrogel shows two obvious temperature response transitions: poly (N-isopropylacrylamide) phase transition in a low-temperature region (about 15-35 DEG C) and thermal association of hydroxyl-containing cellulose in a high-temperature region (about 45-65 DEG C). The pyrophosphate ions enhance the network stability and mechanical strength of the gel through ion-dipole interaction. The hydrogel has excellent mechanical properties and sensitive dual-threshold thermal response characteristics, and can be used in the fields of flexible temperature sensors, bionic skins, temperature control switches, multi-temperature-zone environment monitoring and the like.

The application discloses a method for preparing fluorine-containing diphenylmethane compounds by using sulfur hexafluoride as a fluorination reagent, and belongs to the technical field of organic chemical synthesis. The preparation method comprises the following steps: (1) mixing a photocatalyst, a solvent and a reducing agent, and performing ultrasonic treatment to obtain solution A; mixing a reaction substrate and the solvent to obtain solution B; the photocatalyst is one or more of 4CzIPN, Ir[dF(CF3)ppy]2(dtbpy))PF6, 9-thioxanthone and 10-phenylphenothiazine; the reaction substrate is a compound with a structural formula of R1 and R2 are both H, alkoxy or halogen; (2) mixing the obtained solution A and solution B in a sulfur hexafluoride gas atmosphere, and performing reaction under blue light illumination, and the fluorine-containing diphenylmethane compounds are obtained. The method has the beneficial effects that the fluorine-containing diphenylmethane compounds are efficiently prepared by using sulfur hexafluoride as the fluorination reagent, and by selecting raw materials and catalysts with certain proportions; the reaction raw materials are cheap; the preparation process is safe, mild, has good substrate compatibility and high preparation efficiency.

The invention relates to the technical field of medical materials, and discloses a deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-demineralization functions as well as a preparation method and application of the deep eutectic eutectoid gel coating. The preparation method comprises the following steps: preparing a deep eutectic solvent by mixing SBMA and glycerol or glycerol and gallic acid; the preparation method comprises the following steps: adding a cross-linking agent ethylene glycol dimethacrylate and an initiator into a deep eutectic solvent, uniformly mixing, coating on a PETG substrate, and curing under the action of the initiator to form a continuous and compact deep eutectic eutectoid gel coating. A dense hydrogen bond network is constructed through a deep eutectic system formed by SBMA and glycerin, the hydrophilicity and lubricity of the coating are remarkably improved, adhesion of bacteria and protein in the oral cavity can be effectively reduced, cleanliness of the surface of the appliance is kept, a feasible and efficient technical path is provided for long-term biological functionalization of the invisible appliance, and the application prospect is wide. Meanwhile, the coating can be extensively applied to the fields of other oral medical instruments and biological functional coatings.

The invention relates to the technical field of organic fertilizers and soil remediation. The invention provides a microbial organic compound fertilizer for soil remediation. The microbial organic compound fertilizer is characterized in that a complex formed by covalent bonding of modified UiO-66 (Zr) bifunctional ligand MOF nanoparticles and low-temperature activated wood biochar through an epoxy silane coupling agent is taken as a core; a PEC microcapsule shell formed by chitosan salt and sodium carboxymethyl cellulose under the near-neutral and low-salt condition is coated outside the PEC microcapsule; phosphorus solubilizing bacteria with metal response regulation and control are packaged inside, trehalose, skimmed milk powder and glycerin are matched for keeping alive, and low-temperature drying and granulation are carried out. The compound fertilizer can release phosphorus as required at a pollution peak value, stabilize and passivate heavy metals such as Cd, Pb and the like, the availability of available phosphorus and crops is improved, the finished product viable bacteria is greater than or equal to 1 * 10 CFU / g, and the water content is 1t; the structure is stable, and the storage and transportation performance is excellent.

The application discloses a kind of modular hydrogel based on liquid shaping technology, preparation method and application thereof.The method first utilizes the plasticity of liquid rubber clay, and obtains the temporary mold of specific shape by pressing or cutting, which is composed of micro-nano particle shell;The mixture containing photosensitive hydrogel precursor, nanoclay and functional factor is injected into the mold and light-cured to form a hydrogel module;Optionally, after removing the particle mold, a functionalized hydrogel module with specific morphology, non-adhesion to the substrate and adjustable mechanical properties is obtained;Finally, different functional modules are bonded and cured by hydrogel precursor to integrate into a modular hydrogel with spatial heterostructure.The application uses micro-nano particle shell as a shapeable and removable temporary mold, realizes the adjustable design of hydrogel macroscopic morphology, mechanical properties and spatiotemporal sequence of drug release, and has wide application prospect in the field of tissue engineering and regenerative medicine.

The invention discloses a small organic molecule modified composite photocatalyst as well as a preparation method and application thereof. The composite photocatalyst comprises small organic molecules and a photocatalyst containing active vacancies, wherein the small organic molecules can interact with the active vacancies and are embedded into the active vacancies; the active vacancies are generated by carrying out chemical etching treatment on the surface of the photocatalyst; the photocatalyst is an oxide, a sulfide or a nitride, and the composite photocatalyst enhances CO2 adsorption and electron transfer efficiency and improves separation efficiency, so that the catalyst can perform photocatalytic CO2 reduction under sunlight, and shows good catalytic stability under long-term continuous illumination.

The invention discloses hydrogel with a spontaneous negative swelling behavior as well as a preparation method and application of the hydrogel, and belongs to the technical field of biological materials. The hydrogel disclosed by the invention is prepared from sodium alginate (SA) and recombinant human-like collagen (RHLC) with a specific Gly-Xaa-Yaa repetitive sequence through an internal ion cross-linking method; the hydrogel can spontaneously generate negative swelling in a water-based environment without any external stimulation, the maximum weight reduction rate exceeds 26%, and network structure densification and self-enhancement of mechanical properties are realized in the process; the hydrogel solves the problems that the traditional hydrogel is easy to swell and unstable in mechanical property, and has extremely high application value in the fields of intelligent wound dressings, controllable drug release, cosmetics (lifting efficacy eye masks or facial masks), flexible sensors and the like.

The application provides a fluorine-containing polymer for spleen-selective nucleic acid delivery, a polymer-lipid hybrid nanoparticle and a preparation method and application thereof. The preparation method of the fluorine-containing polymer for spleen-selective nucleic acid delivery comprises the following steps: preparing the fluorine-containing polymer through ring-opening addition reaction of alkylene oxide, fluorine-substituted alkylene oxide and polyethylene imine. The preparation method of the fluorine-containing polymer is simple, the conditions are mild, and the yield of the finished product is high; the obtained fluorine-containing polymer is used for preparing the polymer-lipid hybrid nanoparticle, nucleic acid can be specifically delivered to the spleen and play a role, the polymer-lipid hybrid nanoparticle has a good transfection effect on spleen dendritic cells, and has good biological safety.

This invention discloses a method for synthesizing bio-nano selenium using Beauveria bassiana, belonging to the field of nano-selenium synthesis technology. The method specifically includes the following steps: (1) activating and culturing Beauveria bassiana with accession number CGMCC 3.6914 in a liquid culture medium to obtain a spore suspension; (2) inoculating the spore suspension into a solid culture medium, simultaneously adding Na2SeO3 mother liquor, and then performing shaking culture. After the culture is completed, mixture a is obtained; (3) mixture a is separated, purified, and freeze-dried to obtain bio-nano selenium powder. The method for biosynthesizing nano-selenium in this invention utilizes Beauveria bassiana B26 (… Beauveria bassiana The metabolic activity of the substance reduces Na2SeO3 to nano-selenium, which has high synthesis efficiency, low cost and low pollution. The preparation process is simple and has great economic and environmental benefits.