18results about How to "Gentle preparation" patented technology

The invention provides a probiotic enteric dry suspension as well as a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations. The probiotic enteric dry suspension comprises the following components in parts by mass: 1-8 parts of probiotic powder; 25 to 60 parts of a microcapsule cross-linking system; 1-15 parts of a suspending aid; 20 to 70 parts of a filling agent; 0-0.1 part of a coloring agent; and 0-1 part of an aromatic. According to the invention, when the probiotic powder is dispersed in water by utilizing the gelling property of sodium alginate, the probiotic powder is wrapped to form a probiotic-sodium alginate compound, citric acid and calcium carbonate are subjected to an acid-base reaction, and generated carbon dioxide bubbles can prevent the probiotic-sodium alginate compound from agglomerating; meanwhile, the released calcium ions and chitosan interact with the probiotic-sodium alginate compound, a compact probiotic microcapsule structure is rapidly and stably formed in one step, the probiotics in the microcapsule are effectively protected from being damaged by gastric acid and bile, the survival rate of the probiotics is increased, and the enteric effect is achieved.

The application discloses a kind of polyacrylamide thickening agent for fracturing and preparation method thereof, belong to thickening agent technical field;The thickening agent includes the following weight parts of raw materials: anionic polyacrylamide 88~92 parts, chitosan 3~7 parts, lignosulfonate 3~7 parts;Among them, the anionic polyacrylamide is prepared by aqueous solution polymerization method under the action of initiator by acrylamide monomer and acrylic acid monomer, and the acrylic acid structural unit content is 5%~9%;The application is synergized by anionic polyacrylamide, chitosan, lignosulfonate, solves the problem that traditional polyacrylamide thickening agent is poor in temperature resistance and salt resistance, and environmental protection is insufficient, has good industrial application value.

The invention discloses a composite nanofiltration membrane and a preparation method and application thereof, and belongs to the technical field of composite membranes, and the preparation method comprises the following steps: carrying out interfacial polymerization reaction on a terephthalaldehyde mesitylene solution and an ethylenediamine aqueous solution on the surface of an HPAN membrane at a two-phase junction at normal temperature to obtain the composite nanofiltration membrane. The invention also discloses the composite nanofiltration membrane prepared by the preparation method and application of the composite nanofiltration membrane in sewage treatment. Compared with a traditional interfacial polymerization nanofiltration membrane, the obtained composite nanofiltration membrane has the advantages that the preparation process is simpler, quicker and milder, the stability is extremely high, the antifouling capacity is high, and the composite nanofiltration membrane can be used for dye wastewater treatment.

The invention belongs to the technical field of electro-catalysis, and particularly relates to a cobalt-based oxygen evolution catalyst and a preparation method and application thereof. According to the cobalt-based oxygen evolution catalyst, a cobalt-based precursor material is coated with a uniform cobalt-based boride nanosheet layer to form a petal structure. The catalyst has good water electrolysis oxygen evolution reaction catalytic performance.

The invention discloses a pure physical cross-linked dual-temperature-sensitive hydrogel and a preparation method of the pure physical cross-linked dual-temperature-sensitive hydrogel. The hydrogel is composed of N-isopropylacrylamide, hydroxyl-containing cellulose, sodium pyrophosphate (Na4P2O7) and an initiator, a chemical cross-linking agent is not needed, and a dual physical cross-linked network is formed through combination of photo-initiation or thermal-initiation polymerization and heating induced phase transformation. The obtained hydrogel shows two obvious temperature response transitions: poly (N-isopropylacrylamide) phase transition in a low-temperature region (about 15-35 DEG C) and thermal association of hydroxyl-containing cellulose in a high-temperature region (about 45-65 DEG C). The pyrophosphate ions enhance the network stability and mechanical strength of the gel through ion-dipole interaction. The hydrogel has excellent mechanical properties and sensitive dual-threshold thermal response characteristics, and can be used in the fields of flexible temperature sensors, bionic skins, temperature control switches, multi-temperature-zone environment monitoring and the like.

The application discloses a method for preparing fluorine-containing diphenylmethane compounds by using sulfur hexafluoride as a fluorination reagent, and belongs to the technical field of organic chemical synthesis. The preparation method comprises the following steps: (1) mixing a photocatalyst, a solvent and a reducing agent, and performing ultrasonic treatment to obtain solution A; mixing a reaction substrate and the solvent to obtain solution B; the photocatalyst is one or more of 4CzIPN, Ir[dF(CF3)ppy]2(dtbpy))PF6, 9-thioxanthone and 10-phenylphenothiazine; the reaction substrate is a compound with a structural formula of R1 and R2 are both H, alkoxy or halogen; (2) mixing the obtained solution A and solution B in a sulfur hexafluoride gas atmosphere, and performing reaction under blue light illumination, and the fluorine-containing diphenylmethane compounds are obtained. The method has the beneficial effects that the fluorine-containing diphenylmethane compounds are efficiently prepared by using sulfur hexafluoride as the fluorination reagent, and by selecting raw materials and catalysts with certain proportions; the reaction raw materials are cheap; the preparation process is safe, mild, has good substrate compatibility and high preparation efficiency.

The invention relates to fluorinated nanoparticles and a preparation method of waterproof synthetic leather loaded by the fluorinated nanoparticles. According to the preparation method, tetraethyl orthosilicate and aminopropyltriethoxysilane are taken as raw materials, a SiO2 nano-particle precursor is prepared by using a # imgabs0 # method, chemical modification is performed by using fluorine-free silane, the fluorinated nano-particles are prepared, and the preparation method is relatively mild, simple and feasible. In the process of loading the nanoparticles with different fluorine contents on the microfiber leather, the reaction operation is simple and convenient, and the yield is high. In the whole reaction process, the solvent is recycled, the reaction yield is improved, and environmental pollution is reduced. The fluorinated nano-particles prepared by the method are loaded on the microfiber leather through in-situ growth on the fiber surface, the fluorinated nano-particles are uniformly distributed on the fiber surface, the surface hydrophobic angle can reach 150 degrees or above, the hydrophobic effect of microfibers is improved, and the method has very important significance on development of new synthetic leather materials.

The invention provides a fluorine-containing polymer for spleen selective nucleic acid delivery, a polymer lipid hybrid nanoparticle and a preparation method and application of the polymer lipid hybrid nanoparticle. The preparation method of the fluorine-containing polymer for spleen selective nucleic acid delivery comprises the step of carrying out ring-opening addition reaction on alkylene oxide, fluorine-substituted alkylene oxide and polyethyleneimine to prepare the fluorine-containing polymer. The preparation method of the fluorine-containing polymer is simple, mild in condition and high in finished product yield; the obtained fluorine-containing polymer is used for preparing polymer lipid hybrid nanoparticles, nucleic acid can be specifically delivered to the spleen and plays a role, and the fluorine-containing polymer has a good transfection effect on the dendritic cells of the spleen and also has good biological safety.

The invention relates to the technical field of medical materials, and discloses a deep eutectic eutectoid gel coating with antibacterial, anti-adhesion and anti-demineralization functions as well as a preparation method and application of the deep eutectic eutectoid gel coating. The preparation method comprises the following steps: preparing a deep eutectic solvent by mixing SBMA and glycerol or glycerol and gallic acid; the preparation method comprises the following steps: adding a cross-linking agent ethylene glycol dimethacrylate and an initiator into a deep eutectic solvent, uniformly mixing, coating on a PETG substrate, and curing under the action of the initiator to form a continuous and compact deep eutectic eutectoid gel coating. A dense hydrogen bond network is constructed through a deep eutectic system formed by SBMA and glycerin, the hydrophilicity and lubricity of the coating are remarkably improved, adhesion of bacteria and protein in the oral cavity can be effectively reduced, cleanliness of the surface of the appliance is kept, a feasible and efficient technical path is provided for long-term biological functionalization of the invisible appliance, and the application prospect is wide. Meanwhile, the coating can be extensively applied to the fields of other oral medical instruments and biological functional coatings.

The invention relates to the technical field of organic fertilizers and soil remediation. The invention provides a microbial organic compound fertilizer for soil remediation. The microbial organic compound fertilizer is characterized in that a complex formed by covalent bonding of modified UiO-66 (Zr) bifunctional ligand MOF nanoparticles and low-temperature activated wood biochar through an epoxy silane coupling agent is taken as a core; a PEC microcapsule shell formed by chitosan salt and sodium carboxymethyl cellulose under the near-neutral and low-salt condition is coated outside the PEC microcapsule; phosphorus solubilizing bacteria with metal response regulation and control are packaged inside, trehalose, skimmed milk powder and glycerin are matched for keeping alive, and low-temperature drying and granulation are carried out. The compound fertilizer can release phosphorus as required at a pollution peak value, stabilize and passivate heavy metals such as Cd, Pb and the like, the availability of available phosphorus and crops is improved, the finished product viable bacteria is greater than or equal to 1 * 10 CFU / g, and the water content is 1t; the structure is stable, and the storage and transportation performance is excellent.

The application discloses a kind of modular hydrogel based on liquid shaping technology, preparation method and application thereof.The method first utilizes the plasticity of liquid rubber clay, and obtains the temporary mold of specific shape by pressing or cutting, which is composed of micro-nano particle shell;The mixture containing photosensitive hydrogel precursor, nanoclay and functional factor is injected into the mold and light-cured to form a hydrogel module;Optionally, after removing the particle mold, a functionalized hydrogel module with specific morphology, non-adhesion to the substrate and adjustable mechanical properties is obtained;Finally, different functional modules are bonded and cured by hydrogel precursor to integrate into a modular hydrogel with spatial heterostructure.The application uses micro-nano particle shell as a shapeable and removable temporary mold, realizes the adjustable design of hydrogel macroscopic morphology, mechanical properties and spatiotemporal sequence of drug release, and has wide application prospect in the field of tissue engineering and regenerative medicine.

The invention discloses a small organic molecule modified composite photocatalyst as well as a preparation method and application thereof. The composite photocatalyst comprises small organic molecules and a photocatalyst containing active vacancies, wherein the small organic molecules can interact with the active vacancies and are embedded into the active vacancies; the active vacancies are generated by carrying out chemical etching treatment on the surface of the photocatalyst; the photocatalyst is an oxide, a sulfide or a nitride, and the composite photocatalyst enhances CO2 adsorption and electron transfer efficiency and improves separation efficiency, so that the catalyst can perform photocatalytic CO2 reduction under sunlight, and shows good catalytic stability under long-term continuous illumination.

The invention discloses hydrogel with a spontaneous negative swelling behavior as well as a preparation method and application of the hydrogel, and belongs to the technical field of biological materials. The hydrogel disclosed by the invention is prepared from sodium alginate (SA) and recombinant human-like collagen (RHLC) with a specific Gly-Xaa-Yaa repetitive sequence through an internal ion cross-linking method; the hydrogel can spontaneously generate negative swelling in a water-based environment without any external stimulation, the maximum weight reduction rate exceeds 26%, and network structure densification and self-enhancement of mechanical properties are realized in the process; the hydrogel solves the problems that the traditional hydrogel is easy to swell and unstable in mechanical property, and has extremely high application value in the fields of intelligent wound dressings, controllable drug release, cosmetics (lifting efficacy eye masks or facial masks), flexible sensors and the like.

The invention discloses a 5-aryl benzophenanthridine-6 (5H)-ketone C-N axial chiral compound. The structure of the 5-aryl benzophenanthridine-6 (5H)-ketone C-N axial chiral compound is shown as a formula I in the specification. The invention further discloses a preparation method of the 5-aryl benzophenanthridine-6 (5H)-ketone C-N axial chiral compound, compounds shown in a general formula II and a general formula III are used as raw materials and react in a solvent under the action of a palladium catalyst, norbornene, a chiral ligand, alkali and an additive, and after the reaction is finished, a reaction product is separated to obtain the 5-aryl benzophenanthridine-6 (5H)-ketone C-N axial chiral compound. The method has the advantages of cheap and easily available raw materials, simple preparation process, wide substrate application range, high product yield and high enantioselectivity, and the prepared 5-aryl benzophenanthridine-6 (5H)-ketone C-N axial chiral compound has wide application prospects in the fields of asymmetric catalysis and photoelectric materials. # imgabs0 #

The present invention relates to a side chain-capped polycarboxylate water reducer and a preparation method thereof. In parts by weight, the raw materials for preparing the side chain-capped polycarboxylate water reducer include: 140-170 parts of unsaturated polyether monomer A; 30-60 parts of modified polyether monomer; 8-14 parts of slow-release functional monomer; 4-10 parts of water-reducing functional monomer; 4-15 parts of unsaturated carboxylic acid and / or unsaturated carboxylic acid ester; 0.5-3.0 parts of initiator; 0.1-1.0 parts of reducing agent; 0.2-2.0 parts of chain transfer agent; and 204-240 parts of water; the present invention introduces a phosphate ester with an amide structure into the side chain of the water reducer by copolymerizing the slow-release functional monomer, and the phosphate ester group can form a thin layer of calcium phosphate on the surface of montmorillonite in a concrete environment, thereby improving the intercalation adsorption resistance, and the amide group slowly releases more carboxylic acid groups through hydrolysis in the alkaline environment of the concrete, thereby achieving that the mixed concrete can maintain a fluid state for a long time. At the same time, the hydroxyl group in the molecular structure is a hydrophilic group with strong activity, which enhances the adsorption and dispersion effect on the surface of cement powder and improves the working performance of concrete.

The invention discloses a bio-based low-rolling-resistance improving auxiliary agent as well as a preparation method and application thereof. The auxiliary agent is prepared by heating and mixing a bio-based raw material, PEG (polyethylene glycol) and a high-flash-point amine raw material, the bio-based raw material is one or more of oleamide, erucyl amide, octadecanamide and bis (ethylene) octadecanamide; the molecular weight of PEG is more than 1000g / mol; the amine raw material with the high flash point is N, N-dimethylethanolamine and / or N, N-dimethyl-3-methoxypropylamine, and the amine raw material with the high flash point is N, N-dimethylethanolamine and / or N, N-dimethyl-3-methoxypropylamine. The preparation method comprises the following steps: heating and stirring the bio-based raw materials until the bio-based raw materials are molten, then adding PEG, continuously stirring, sufficiently and uniformly mixing, then adding the high-flash-point amine raw materials, and continuously heating and stirring until all the raw materials are molten into a liquid state. A rubber tire prepared by adding the improvement auxiliary agent into a tread rubber material can effectively reduce the rolling resistance and improve the production safety, and is environment-friendly.

The application provides a fluorine-containing polymer for spleen-selective nucleic acid delivery, a polymer-lipid hybrid nanoparticle and a preparation method and application thereof. The preparation method of the fluorine-containing polymer for spleen-selective nucleic acid delivery comprises the following steps: preparing the fluorine-containing polymer through ring-opening addition reaction of alkylene oxide, fluorine-substituted alkylene oxide and polyethylene imine. The preparation method of the fluorine-containing polymer is simple, the conditions are mild, and the yield of the finished product is high; the obtained fluorine-containing polymer is used for preparing the polymer-lipid hybrid nanoparticle, nucleic acid can be specifically delivered to the spleen and play a role, the polymer-lipid hybrid nanoparticle has a good transfection effect on spleen dendritic cells, and has good biological safety.

This invention discloses a method for synthesizing bio-nano selenium using Beauveria bassiana, belonging to the field of nano-selenium synthesis technology. The method specifically includes the following steps: (1) activating and culturing Beauveria bassiana with accession number CGMCC 3.6914 in a liquid culture medium to obtain a spore suspension; (2) inoculating the spore suspension into a solid culture medium, simultaneously adding Na2SeO3 mother liquor, and then performing shaking culture. After the culture is completed, mixture a is obtained; (3) mixture a is separated, purified, and freeze-dried to obtain bio-nano selenium powder. The method for biosynthesizing nano-selenium in this invention utilizes Beauveria bassiana B26 (… Beauveria bassiana The metabolic activity of the substance reduces Na2SeO3 to nano-selenium, which has high synthesis efficiency, low cost and low pollution. The preparation process is simple and has great economic and environmental benefits.