The invention discloses an olmesartan medoxomil amlodipine tablet and a preparation method thereof. The olmesartan medoxomil amlodipine tablet is prepared by smashing, tabletting and coating olmesartan medoxomil, amlodipine besylate, silicified microcrystalline cellulose, pregelatinized starch, crosslinked sodium carboxymethyl cellulose, calcium hydrogen phosphate, sodium carboxymethyl starch, magnesium stearate, titanium dioxide, talcum powder, a coating premix and the like, has an ideal clinical therapeutic effect, and effectively improves the stability of the drug release of the compound medicine, the raw materials in the preparation process are all subjected to powder processing, the preparation process is simple, and the finally obtained olmesartan medoxomil amlodipine tablet has strong stability, fast dispersion, good absorption and a good clinical application prospect.