Application of chlorogenic acid to preparing medicine for treating Hutchinson-Gilford syndrome

A technology of chlorogenic acid and progeria, which is applied in the application field of chlorogenic acid in the preparation of drugs for treating progeria, can solve the problems that there is no chlorogenic acid to treat progeria, and achieve good clinical application prospects and small side effects Effect

Inactive Publication Date: 2015-06-10
SICHUAN JIUZHANG BIO TECH CO LTD
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no relevant literature rep

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of chlorogenic acid to preparing medicine for treating Hutchinson-Gilford syndrome
  • Application of chlorogenic acid to preparing medicine for treating Hutchinson-Gilford syndrome
  • Application of chlorogenic acid to preparing medicine for treating Hutchinson-Gilford syndrome

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Example 1 Preparation of freeze-dried powder injection with chlorogenic acid

[0017] 1. Extraction of chlorogenic acid:

[0018] The chlorogenic acid raw material used in this example is obtained by extraction and purification from Eucommia ulmoides leaves, with a purity of 99.56%.

[0019] 2. Preparation of chlorogenic acid freeze-dried powder injection

[0020] 2.1 Prescription:

[0021]

[0022] Add the above prescription to the water for injection, stir until it is completely dissolved, adjust the pH, filter with a 0.22μm sterile microporous membrane, and make a total of 2000 2ml powder injections according to the usual operation of sterile freeze-dried powder injections, each Contains 50mg of chlorogenic acid.

Example Embodiment

[0023] Example 2 Preparation of pills with chlorogenic acid

[0024] 1. Extraction of chlorogenic acid

[0025] The chlorogenic acid used in this example was extracted and purified from honeysuckle, with a purity of 98.22%.

[0026] 2. Preparation of chlorogenic acid pills

[0027] 2.1 Prescription

[0028]

[0029] 2.2. Manufacturing method:

[0030] Take an appropriate amount of povidone K30 and prepare a solution with absolute ethanol, then take the prescription amount of chlorogenic acid and starch, and mix them evenly by the equal dilution method, add them to the ethanol solution of povidone K30, and stir well. The soft material is obtained, and 1000 chlorogenic acid pills are prepared by rubbing the pill method, and each pill contains 1 mg of chlorogenic acid.

Example Embodiment

[0031] Example 3 Preparation of oral solution with chlorogenic acid

[0032] 1. Extraction of chlorogenic acid

[0033] The chlorogenic acid used in this example was extracted and purified from Eucommia ulmoides leaves, with a purity of 99.88%.

[0034] 2. Preparation of chlorogenic acid oral solution

[0035] 2.1 Prescription

[0036]

[0037] 2.2 Preparation method

[0038] Take the prescribed amount of chlorogenic acid and sodium metabisulfite, dissolve them in 10L of water for injection, follow the conventional preparation process of oral liquid, after filtration, aseptically fill 1000 oral liquids, each oral liquid is 10mL, containing chlorogenic acid 300mg.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides an application of chlorogenic acid to preparing a medicine for treating Hutchinson-Gilford syndrome. Chlorogenic acid can treat Hutchinson-Gilford syndrome effectively and has a better curative effect than a positive medicine rapamycin; and chlorogenic acid is safe and has few side effects and a favorable clinical application prospect.

Description

technical field [0001] The invention relates to the use of chlorogenic acid in the preparation of medicine for treating progeria. Background technique [0002] Progeria (progeria) is a genetic disease. The aging process of the body is 5 to 10 times faster than normal. The patient looks like an old man, and the organs also decline quickly, resulting in a decline in physiological functions. Symptoms that are more common in children with progeria include: hair loss, late eruption of teeth, short stature, and loss of subcutaneous fat. Sick children generally can only live to be 7 to 20 years old, and most of them will die from aging diseases, such as cardiovascular diseases. There is no effective treatment method at present, and only drugs are used for treatment. [0003] It has been reported in the literature that chlorogenic acid can effectively scavenge free radicals in the body, maintain the normal structure and function of body cells, and prevent and delay tumors, mutation...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/216A61P43/00
Inventor 张洁贾静黄望
Owner SICHUAN JIUZHANG BIO TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap