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Application of chlorogenic acid to preparing medicine for treating Hutchinson-Gilford syndrome

A technology of chlorogenic acid and progeria, which is applied in the application field of chlorogenic acid in the preparation of drugs for treating progeria, can solve the problems that there is no chlorogenic acid to treat progeria, and achieve good clinical application prospects and small side effects Effect

Inactive Publication Date: 2015-06-10
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no relevant literature report on the treatment of progeria with chlorogenic acid

Method used

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  • Application of chlorogenic acid to preparing medicine for treating Hutchinson-Gilford syndrome
  • Application of chlorogenic acid to preparing medicine for treating Hutchinson-Gilford syndrome
  • Application of chlorogenic acid to preparing medicine for treating Hutchinson-Gilford syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 prepares freeze-dried powder injection with chlorogenic acid

[0017] 1. Extraction of chlorogenic acid:

[0018] The chlorogenic acid crude drug used in this example is obtained by extracting and purifying Eucommia leaves, with a purity of 99.56%.

[0019] 2. Preparation of chlorogenic acid freeze-dried powder injection

[0020] 2.1 Prescription:

[0021]

[0022] Add the above prescription into water for injection, stir until it is completely dissolved, adjust the pH, filter it with a 0.22 μm sterile microporous filter membrane, and make a total of 2000 2ml powder injections according to the routine operation of sterile freeze-dried powder injection, each Contains chlorogenic acid 50mg.

Embodiment 2

[0023] Embodiment 2 prepares pills with chlorogenic acid

[0024] 1. Extraction of chlorogenic acid

[0025] The chlorogenic acid used in this example is extracted and purified from Flos Lonicerae, with a purity of 98.22%.

[0026] 2. Preparation of Chlorogenic Acid Pellets

[0027] 2.1 Prescription

[0028]

[0029] 2.2. Preparation method:

[0030] Take an appropriate amount of povidone K30, prepare a solution with absolute ethanol, then take the prescribed amount of chlorogenic acid and starch, mix them uniformly by equal dilution, add the ethanol solution of povidone K30, and stir well to make The soft material was obtained, and 1000 chlorogenic acid pills were prepared by rubbing pills, each pill containing 1 mg of chlorogenic acid.

Embodiment 3

[0031] Embodiment 3 prepares oral solution with chlorogenic acid

[0032] 1. Extraction of chlorogenic acid

[0033] The chlorogenic acid used in this example is extracted and purified from Eucommia ulmoides leaves with a purity of 99.88%.

[0034] 2. Preparation of Chlorogenic Acid Oral Solution

[0035] 2.1 Prescription

[0036]

[0037] 2.2 Preparation method

[0038] Take the prescribed amount of chlorogenic acid and sodium metabisulfite, dissolve in 10L water for injection, filter according to the conventional preparation process of oral liquid, and aseptically fill into 1000 oral liquids, each oral liquid is 10mL, containing chlorogenic acid 300mg.

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Abstract

The invention provides an application of chlorogenic acid to preparing a medicine for treating Hutchinson-Gilford syndrome. Chlorogenic acid can treat Hutchinson-Gilford syndrome effectively and has a better curative effect than a positive medicine rapamycin; and chlorogenic acid is safe and has few side effects and a favorable clinical application prospect.

Description

technical field [0001] The invention relates to the use of chlorogenic acid in the preparation of medicine for treating progeria. Background technique [0002] Progeria (progeria) is a genetic disease. The aging process of the body is 5 to 10 times faster than normal. The patient looks like an old man, and the organs also decline quickly, resulting in a decline in physiological functions. Symptoms that are more common in children with progeria include: hair loss, late eruption of teeth, short stature, and loss of subcutaneous fat. Sick children generally can only live to be 7 to 20 years old, and most of them will die from aging diseases, such as cardiovascular diseases. There is no effective treatment method at present, and only drugs are used for treatment. [0003] It has been reported in the literature that chlorogenic acid can effectively scavenge free radicals in the body, maintain the normal structure and function of body cells, and prevent and delay tumors, mutation...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P43/00
Inventor 张洁贾静黄望
Owner SICHUAN JIUZHANG BIO TECH CO LTD
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