Nifuratel gel and process for preparing same

A technology of nifuratel gel and nifuratel, which is applied in the field of chemical medicine and pharmaceuticals, and can solve the problems of limited use and contaminated clothes

Inactive Publication Date: 2008-06-18
程雪翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nifuratel is currently on the market in the form of oral tablets, vaginal tablets, compound vaginal soft capsules, and compound vaginal ointment. However, at present, each dosage form has disadvantages such as contamination of clothes to varying degrees, and its clinical use is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] prescription:

[0069] Nifuratel 10g

[0070] Carbomer 1.0g

[0071] Propylene glycol 5.0g

[0072] Ethylparaben 0.32g

[0073] Triethanolamine 0.8g

[0074] Ethanol 5.7g

[0075] Distilled water up to 100g

[0076] Preparation method: Take an appropriate amount of distilled water, sprinkle carbomer into the water under high-speed stirring, and continue to stir until it is completely dispersed; dissolve 5.0g of propylene glycol in appropriate amount of distilled water, mix evenly with the carbomer solution, and add 0.8g of carbomer under low-speed stirring Triethanolamine, to form a gel matrix; dissolve ethylparaben in an appropriate amount of hot distilled water, and put it at room temperature; dissolve 10g of nifuratel in ethanol, dissolve it in a small amount of distilled water, and add this solution under stirring Add ethylparaben solution to the gel matrix, add water to a sufficient amount, and stir evenly to obtain nifuratel gel with a pH value of 5.5-6.5. ...

Embodiment 2

[0078] prescription:

[0079] Nifuratel 8g

[0080] Carbomer 0.8g

[0081] Propylene glycol 6g

[0082] Ethylparaben 0.25g

[0083] Triethanolamine 0.8g

[0084] Ethanol 4.8g

[0085] Distilled water up to 100g

[0086] Preparation method: Take an appropriate amount of distilled water, sprinkle carbomer into the water under high-speed stirring, and continue to stir until it is completely dispersed; dissolve 6g of propylene glycol in appropriate amount of distilled water, mix with the carbomer solution evenly, and add 0.8g of three Ethanolamine to form a gel matrix; dissolve ethylparaben in an appropriate amount of hot distilled water, and put it at room temperature; dissolve 8g of nifuratel in ethanol, dissolve it in a small amount of distilled water, and add this solution to the condensate under stirring Add ethylparaben solution to the gel matrix, add water to a sufficient amount, and stir evenly to obtain nifuratel gel with a pH value of 5.5-6.5.

Embodiment 3

[0088] prescription:

[0089] Nifuratel 15g

[0090] Carbomer 1.2g

[0091] Propylene glycol 6g

[0092] Ethylparaben 0.38g

[0093] Triethanolamine 1.3g

[0094] Ethanol 8.1g

[0095] Distilled water up to 100g

[0096] Preparation method: Take an appropriate amount of distilled water, sprinkle carbomer into the water under high-speed stirring, and continue to stir until it is completely dispersed; dissolve 6g of propylene glycol in appropriate amount of distilled water, mix with the carbomer solution evenly, and add 1.3g of three Ethanolamine to form a gel matrix; dissolve ethylparaben in an appropriate amount of hot distilled water, and put it at room temperature; dissolve 15g of nifuratel in ethanol, dissolve it in a small amount of distilled water, and add this solution to the gelatin Add ethylparaben solution to the gel matrix, add water to a sufficient amount, and stir evenly to obtain nifuratel gel with a pH value of 5.5-6.5.

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PUM

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Abstract

The invention provides a nifuratel gel and the related preparation method. The invention is made of nifuratel as the raw material, a gel substrate carbomer and other relative auxiliary materials and used to cure vulvar and vaginal infections and vaginal mixed infections caused by germs, trichomonads and candidas. The invention has the advantages of obvious curative effect, relative stable quality, and is convenient to carry and take, and is safe and sanitary. The invention is comprehensively improved in quality, and enriches the medication varieties after the formulation is changed, thus the invention has great significance for further meeting and guaranteeing the medication requirements of people.

Description

technical field [0001] The invention relates to the field of chemical medicine and pharmacy, in particular to a nifuratel gel and a preparation method thereof. Background technique [0002] Bacterial vaginosis (BV) and vaginal trichomoniasis are common and frequently-occurring diseases in obstetrics and gynecology. It is reported that about 75% of women of childbearing age have had one episode of BV, and about 5% can recur. There are more than 200 million people infected with Trichomonas, and BV often coexists with Trichomonas vaginitis. It has been reported that 86% of women with positive cultures of Trichomonas have BV. There are also domestic surveys showing that among 227 gynecological outpatients with increased vaginal discharge or peculiar smell, 120 cases were BV patients, accounting for 43.33%, and 19.17% of them were combined with trichomonas infection (23 / 120); 36 cases of trichomonas vaginitis ( 13%), 31 cases (11.1%) of candidal vaginitis. It can be seen that m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/422A61K47/32A61P31/04A61P33/02A61P15/02
Inventor 程雪翔
Owner 程雪翔
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