Injectable temperature-sensitive hydrogel for cartilage regeneration and repair and preparation method of injectable temperature-sensitive hydrogel

A temperature-sensitive, hydrogel technology, used in tissue regeneration, pharmaceutical formulations, pharmaceutical sciences, etc., can solve the problems of lack of nerves, low self-proliferation, degeneration, etc., and achieve cheap and easy-to-obtain raw materials for clinical applications. Foreground, simple operation method

Inactive Publication Date: 2021-09-17
杭州开腾医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, articular cartilage is easily damaged due to obesity, sports trauma or arthritis, and even a small defect has the potential risk of serious degeneration
Moreover, the tissue structure of articular cartilage is dense, lacks nerves, blood vessels, etc., and the self-proliferation ability of chondrocytes in articular cartilage tissue is relatively low. Therefore, once articular cartilage is damaged, it is difficult to repair itself.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] An injectable temperature-sensitive hydrogel for cartilage regeneration and repair, comprising the following components: chitosan solution 1g / 100ml, collagen solution 0.5g / 100ml, collagen solution 4g / 100ml, decalcified bone matrix Powder 2 parts.

[0030] A kind of preparation method for the injectable temperature-sensitive type hydrogel that is used for processing the cartilage regeneration obtained in above-mentioned repairing, comprises the following steps:

[0031] A. prepare chitosan;

[0032] B. Prepare collagen;

[0033] C. preparing demineralized bone matrix;

[0034] D. Preparation of thermosensitive hydrogels.

[0035] In described step A, configuration concentration is the acetic acid solution of the chitosan of 2.5%g / ml, first weighs chitosan, then adds aqueous solution in clean beaker, secondly adds acetic acid solution in beaker, under stirring condition Next, put the weighed chitosan into the beaker, and stir, and finally make the chitosan completely ...

Embodiment 2

[0046] An injectable temperature-sensitive hydrogel for cartilage regeneration and repair, comprising the following components: chitosan solution 5g / 100ml, sodium glycerophosphate solution 7g / 100ml, collagen solution 8g / 100ml, decalcified bone matrix powder 5 servings.

[0047] A kind of preparation method for the injectable temperature-sensitive type hydrogel that is used for processing the cartilage regeneration obtained in above-mentioned repairing, comprises the following steps:

[0048] A. prepare chitosan solution;

[0049] B. prepare sodium glycerophosphate solution;

[0050] C. prepare collagen solution;

[0051] D. preparing decalcified bone matrix powder;

[0052] E. Preparation of thermosensitive hydrogels.

[0053] In said step A, configure the acetic acid solution of chitosan with a concentration of 2.5% g / ml, first weigh the chitosan, then add the aqueous solution in a clean beaker, then add the acetic acid solution in the beaker, and stir Finally, the stirr...

Embodiment 3

[0064] An injectable temperature-sensitive hydrogel for cartilage regeneration and repair, comprising the following components: chitosan solution 10g / 100ml, sodium glycerophosphate solution 15g / 100ml, collagen solution 15g / 100ml, decalcified bone matrix powder 10 servings.

[0065] A kind of preparation method for the injectable temperature-sensitive type hydrogel that is used for processing the cartilage regeneration obtained in above-mentioned repairing, comprises the following steps:

[0066] A. prepare chitosan solution;

[0067] B. prepare sodium glycerophosphate solution;

[0068] C. prepare collagen solution;

[0069] D. preparing decalcified bone matrix powder;

[0070] E. Preparation of thermosensitive hydrogels.

[0071] In said step A, configure the acetic acid solution of chitosan with a concentration of 2.5% g / ml, first weigh the chitosan, then add the aqueous solution in a clean beaker, then add the acetic acid solution in the beaker, and stir Finally, the s...

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Abstract

The invention discloses injectable temperature-sensitive hydrogel for cartilage regeneration and repair and a preparation method of the injectable temperature-sensitive hydrogel. The injectable temperature-sensitive hydrogel is prepared from the following components: 1-10g/100ml of a chitosan solution, 0.5-15g/100ml of a sodium glycerophosphate solution, 4-15g/100ml of a collagen solution and 2-10 parts of decalcified bone matrix powder. The injectable temperature-sensitive hydrogel for cartilage regeneration and repair has a temperature-sensitive characteristic, the sol can be implanted into an organ or a defect part in a body through an injector or an endoscope, so that the gel is quickly formed in situ, and the effect of the gel is exerted.

Description

technical field [0001] The invention belongs to the technical field of hydrogel preparation, and in particular relates to an injectable temperature-sensitive hydrogel for cartilage regeneration and repair and a preparation method thereof. Background technique [0002] Articular cartilage is a dense connective tissue that plays an extremely important role in buffering the stress between joints and reducing friction between articular surfaces. However, articular cartilage is easily damaged due to obesity, sports trauma or arthritis, and even a small defect has the potential risk of serious degeneration. Moreover, the tissue structure of articular cartilage is dense, lacks nerves, blood vessels, etc., and the self-proliferation ability of chondrocytes in articular cartilage tissue is relatively low. Therefore, once articular cartilage is damaged, it is difficult to repair itself. [0003] DBM (i.e., demineralized bone matrix) contains relevant bioactive factors and contributes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/36A61L27/24A61L27/20
CPCA61L27/52A61L27/50A61L27/3654A61L27/3608A61L27/3687A61L27/3691A61L27/24A61L27/20A61L2430/06A61L2400/06A61L2430/40C08L5/08
Inventor 李华平
Owner 杭州开腾医疗科技有限公司
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