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Chitosan pellet/microsac and prepn. thereof

A technology of chitosan microspheres and chitosan solutions, which is applied in the fields of medical engineering and bioengineering, can solve the problems of low mechanical strength of chitosan microspheres/microcapsules, and achieve low mechanical strength and reduce activity loss , The effect of improving the mechanical strength

Inactive Publication Date: 2006-09-20
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome when prior art prepares chitosan microsphere / microcapsule, use emulsification dispersion cross-linking method or solvent volatilization method to introduce toxic cross-linking agent or organic solvent, use coacervation method or spray-drying method to prepare Chitosan microspheres / microcapsules have defects of low mechanical strength, so as to provide a kind of chemical cross-linking agent, organic solvent and other harmful substances, with controllable particle size, controllable surface state, controllable swelling property, mutual Non-adhesion, biodegradable chitosan microsphere / microcapsule, and preparation method thereof

Method used

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  • Chitosan pellet/microsac and prepn. thereof
  • Chitosan pellet/microsac and prepn. thereof
  • Chitosan pellet/microsac and prepn. thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Chitosan was dissolved in 0.2mol / L acetic acid solution to prepare a 2% (w / v) solution, 50mL of liquid paraffin was added to the reactor, 0.5mL of Span80 and 1mL of Tween80 were added, stirred for 10 minutes, and the rotating speed was 1500 rpm Minutes, after adding the 10mL chitosan solution prepared above, continue to stir and disperse for 30 minutes with the same rotating speed, then add 40mL of ammonium sulfate solution with a concentration of 50% (w / v), continue to stir for 1 hour and then stop. Centrifuge, pour out the upper liquid, separate the chitosan microspheres precipitated by ammonium sulfate in the lower layer, wash the precipitates with pure water, petroleum ether, and absolute ethanol in turn, and dry them in vacuum at room temperature to obtain the chitosan microspheres of the present invention. ball.

[0035] Its surface morphology is as figure 1 and figure 2 As shown in the scanning electron microscope picture, it can be seen that the chitosan micr...

Embodiment 2

[0037]Dissolve chitosan in 0.25mol / L acetic acid solution to prepare a 5% (w / v) solution, take 50mL peanut oil and add it to the reactor, add 0.5mL Span60 and 1mL Tween60, stir for 5 minutes, and the rotating speed is 2000 rpm After adding the above-mentioned chitosan solution of 10mL, continue to stir after 60 minutes with the same rotating speed, add the ammonium sulfate solution 100mL that concentration is 30% (w / v), stop after continuing to stir for 2 hours. Centrifuge, pour out the upper liquid, separate the chitosan microspheres precipitated by ammonium sulfate in the lower layer, wash the precipitates with pure water, petroleum ether, and absolute ethanol in turn, and dry them in vacuum at room temperature to obtain the chitosan microspheres of the present invention. ball.

[0038] Its surface morphology is as image 3 and Figure 4 As shown in the scanning electron micrograph, it can be seen that the chitosan microspheres have a porous surface, a particle size of 154...

Embodiment 3

[0040] Chitosan was dissolved in 0.25mol / L acetic acid solution to prepare a 4% (w / v) solution, 50mL corn oil was added to the reactor, 1mL Tween65 was added, stirred for 20 minutes, and the rotating speed was 500 rpm; After 2.5mL of the chitosan solution prepared above, continue to stir with the same rotating speed for 40 minutes, add concentration and be 50mL of ammonium sulfate solution of 65% (w / v), stop after continuing to stir for 3 hours. Centrifuge, pour out the upper liquid, separate the chitosan microspheres precipitated by ammonium sulfate in the lower layer, wash the precipitates with pure water, petroleum ether, and absolute ethanol in turn, and dry them in vacuum at room temperature to obtain the chitosan microspheres of the present invention. ball.

[0041] The cross-section of the microsphere is shown in Figure 5 As shown, it can be seen that its internal structure is dense and it is a solid ball.

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Abstract

A chitosan microsphere or microcapsule is prepared through proportionally mixing oil phase with surfactant, stirring, proportionally adding chitosan solution (water phase), stirring, proportionally adding ammonium sulfate solution, stirring, centrifugal separation of deposit, washing and drying.

Description

technical field [0001] The invention belongs to the fields of medical engineering and bioengineering, and specifically relates to a chitosan microsphere / microcapsule with controllable particle size, controllable surface state, controllable swelling property, non-adhesion, and biodegradability. and its preparation method. Background technique [0002] Chitosan [β-(1-4)-2-amino-2-deoxy-D-glucan] is the deacetylation product of chitin, which is abundant in nature, due to its good biocompatibility, biological Degradability and bioadhesion have been widely valued by researchers in the field of medicine and bioengineering materials. Chitosan microspheres / microcapsules have a large surface area to volume ratio, and can be used as a drug carrier to obtain slow-release and controlled-release effects to obtain ideal drug release properties; chitosan microspheres / microcapsules with a certain particle size have targeted It can concentrate the drug on the lesion, improve the therapeuti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/16
Inventor 李巧霞宋宝珍仰振球樊红雷
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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