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Preparation method for oily and oil soluble drug nanocapsules

An oil-soluble, nano-capsule technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Stabilization, improve the encapsulation efficiency, and increase the effect of drug stability

Inactive Publication Date: 2013-06-05
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims to solve the problems of low encapsulation efficiency and large particle size of nanocapsules prepared by existing methods, and provides a preparation method of oily and oil-soluble drug nanocapsules

Method used

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  • Preparation method for oily and oil soluble drug nanocapsules

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specific Embodiment approach 1

[0009] Specific Embodiment 1: In this embodiment, a method for preparing oily and oil-soluble drug nanocapsules includes the following steps: 1. Add gelatin to water, soak for 6-8 hours, heat to dissolve, and let it stand for 15-20 minutes to obtain the mass percent A gelatin solution with a content of 2% to 20%; dissolving chitosan in an acetic acid solution with a mass percentage of 1%, heating and dissolving in a water bath, standing for 1 to 2 hours, and dissolving to obtain a mass percentage of 0.2% to 2% chitosan solution; 2. add the core material to the gelatin solution obtained in step 1 with a mass percentage of 2% to 20%, and after high shear for 30 to 50 seconds, homogenize with a high pressure homogenizer for 3 Second, the particle diameter that obtains is the nanoscale O / W type emulsion; Three, the particle diameter that step 2 obtains is the O / W type emulsion that adds the mass percentage that step 1 obtains and is 0.2%~2% Chitosan solution, stirred at a temperat...

specific Embodiment approach 2

[0011] Embodiment 2: This embodiment differs from Embodiment 1 in that the core material in step 2 is oily medicine or oil-soluble medicine. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0012] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that in Step 3, stirring is carried out at a temperature of 50° C. for 35 minutes. Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention relates to a preparation method for oily and oil soluble drug nanocapsules, and aims at solving the problem that the existing nanocapsules prepared by the existing method have low packing efficiency and are large in grain size. The preparation method comprises the following steps of 1. preparing gelatin solution and chitosan solution; 2. preparing O / W emulsion with grain size of nanoscale; 3. adding the chitosan solution into the O / W emulsion with grain size of nanoscale so as to obtain mixed liquor; and 4. regulating pH value of the mixed liquor so as to obtain compound condensate, diluting the compound condensate and adding a curing agent, and then drying so as to complete the preparation of oily and oil soluble drug nanocapsules. The preparation method for oily and oil soluble drug nanocapsules is applicable to the technical field of medicines.

Description

technical field [0001] The invention relates to a preparation method of oily and oil-soluble drug nanocapsules. Background technique [0002] Nanocapsules, due to their quantum effects, material localization, and huge surface and interface effects, cause qualitative changes in many properties of materials. As a mesoscopic system between macroscopic objects and atoms, it is compatible with both macroscopic objects and atoms. There are common places, but also many unique properties and uses. It combines the properties brought about by the shell-core structure and the effects of nanosystems caused by size changes. The outer shell of nanocapsules has many functions, such as: protecting the inner core from environmental damage; increasing the stability of nanoclusters to avoid their growth; promoting the dispersion of nanoparticles in different media; increasing the activity of substances; Optical, electrical, magnetic properties, etc. [0003] The active ingredients in oily d...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K45/00A61K47/42A61K47/36
Inventor 李强赵学玲龚显峰孙丽建张华
Owner HEILONGJIANG UNIV
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