14results about How to "Improve encapsulation efficiency" patented technology

The invention discloses a strong-absorption water-soluble lutein compound preparation and application thereof in food with an eyesight protection function. The xanthophyll-dipotassium glycyrrhizinate water-soluble granules are water-soluble granules formed by molecular self-assembly of xanthophyll, dipotassium glycyrrhizinate, triterpenic acid, protein and dietary polysaccharide. Compared with untreated xanthophyll, the xanthophyll compound preparation with strong absorption has the advantages that the xanthophyll has good water solubility and stability, the intestinal absorption efficiency is improved by 20-35 times, and eyesight protection can be effectively realized. Meanwhile, the embedding rate is high, the safety is good, and the production cost is low.

This invention belongs to the field of fire extinguishing materials and their preparation technology, and provides a fire extinguishing microcapsule and its microfluidic controllable preparation method. The preparation method is characterized by the following steps: (1) preparing fluids of each phase, (2) preparing a dual emulsion using a microfluidic device, (3) collecting and sealing the dual emulsion in a collection container, controlling the axis of the collection container to be horizontal, and controlling the collection container to rotate around its axis for 1 to 15 minutes, applying light to solidify the outer shell of the dual emulsion droplets while maintaining the rotation of the collection container, cleaning, and drying to obtain the final product. The fire extinguishing microcapsule prepared by this method consists of an outer shell and a liquid fluorine-containing fire extinguishing agent encapsulated within the outer shell. The outer shell of the fire extinguishing microcapsule has a uniform thickness, and the eccentricity between the outer shell and the core is less than 0.1. The method of this invention can achieve precise customization of fire extinguishing microcapsules according to the differentiated fire characteristics of different application scenarios, and can improve the concentricity between the core and the outer shell of existing fire extinguishing microcapsules.

The application discloses a multifunctional injectable hydrogel and a preparation method and application thereof, and relates to the technical field of multifunctional hydrogel preparation and application. In the preparation, CMC-AGE and OD-SH are prepared respectively, and DSPE-se-se-PEG@AC NPs nanoparticles are prepared, then the multifunctional injectable hydrogel is prepared by forming a hydrogel through CMC-AGE and OD-SH and adding DSPE-se-se-PEG@AC NPs nanoparticles and / or beta nerve growth factor. The application also includes the multifunctional injectable hydrogel prepared by the above method and the application thereof. The application constructs an in-situ hydrogel delivery platform with good biocompatibility, is used for co-delivery of DSPE-se-se-PEG@AC NPs and NGF, is used in ischemic stroke treatment, and reshapes the pathological microenvironment of a cerebral infarction area, so that cerebral ischemic injury is reduced.

The invention relates to the technical field of phase change materials, and discloses an MXene / MWCNT reinforced charcoal-based composite phase change material and a preparation method thereof, the preparation method comprises the following steps: S1, preparing MWCNT and a metal salt to obtain a suspension; adding biomass into the suspension, and drying to obtain a precursor; s2, performing heat treatment on the precursor to obtain biochar; blending and drying the biochar and a perfluorooctanoic acid ethanol solution to obtain a support material; s3, blending and drying the support material and an MXene solution to obtain an enhanced support material; s4, the enhanced support material is subjected to a vacuum impregnation method, and the bio-based composite phase change material is obtained. Compared with paraffin and unreinforced composite PCM, the heat conductivity of the composite PCM prepared by the invention is respectively improved by 313.77% and 26.3%. And by adopting the biochar-based support material, the paraffin encapsulation efficiency is improved again and reaches 85.18%.

The invention relates to the technical field of electric power materials, in particular to a super-sticky moisture-proof and fireproof blocking adhesive sticker, the super-sticky moisture-proof and fireproof blocking adhesive sticker takes a PET film as a PET base material, a wear-resistant layer is attached to one side of the PET base material, an adhesive layer is attached to the other side of the PET base material, and the PET base material specifically comprises the following components in parts by weight: 80-100 parts of PET particles, 1-2 parts of a curing agent, 1-2 parts of a curing agent and 1-2 parts of a curing agent. The composite material comprises the following components in parts by weight: 2-5 parts of an acrylonitrile-butadiene-styrene copolymer, 5-8 parts of a flame retardant, 0.5-1.5 parts of nano silicon dioxide, 1-2 parts of filling microfibers and 1-2 parts of isopropyl tri (dodecylbenzenesulfonyl) titanate. The adhesive layer specifically comprises the following components in parts by weight: 20-40 parts of methyl vinyl silicone rubber, 5-15 parts of a rubber elastomer, 5-15 parts of tackifying resin, 20-40 parts of a flame retardant, 30-50 parts of filler and 3-5 parts of plant essential oil microcapsules. The prepared easy-to-stick waterproof, moisture-proof and anti-corrosion coiled material has self-curing performance, the cured easy-to-stick waterproof, moisture-proof and anti-corrosion coiled material can be tightly attached to a protected part, and the easy-to-stick waterproof, moisture-proof and anti-corrosion coiled material has excellent waterproof sealing performance and electric leakage resistance, has excellent high-temperature resistance and atmospheric aging resistance, is good in wear resistance, and can be used as a waterproof, moisture-proof and anti-corrosion coiled material. And the material is high in flame-retardant grade, avoids the risk of delayed combustion, and is flexible and convenient to construct on site.

The invention belongs to the technical field of nutrient nano-embedding, and particularly relates to a rosmarinic acid nano-delivery system as well as a preparation method and application thereof. The rosmarinic acid nano delivery system comprises a wall material and inclusions, the wall material comprises fish skin protein and / or chitosan; the inclusion comprises rosmarinic acid. The rosmarinic acid nano delivery system (RA (at) FSP / CS NCs) provided by the invention not only maintains the excellent antioxidant activity of RA, but also has good stability. The system can effectively remove ABTS < + > free radicals and hydroxyl (. OH) free radicals, and is expected to be applied to the fields of food functional factor or nutrient stabilization and antioxidant activity maintenance.

This invention discloses fucoidan-phycocyanin nanoparticles loaded with astaxanthin. The nanoparticles are formed by the self-assembly of fucoidan and phycocyanin through electrostatic interactions and hydrogen bonds to form a carrier, encapsulating astaxanthin within. The nanoparticles have a particle size of 250 nm–350 nm, an absolute zeta potential ≥20 mV, a polydispersity index ≤0.30, and an astaxanthin encapsulation efficiency ≥78%. The composite preservation film uses carboxymethyl cellulose as the film-forming matrix, with the nanoparticles uniformly dispersed therein. The water contact angle is ≥90°, and the water vapor transmission rate is ≤14%. g·mm / (m²·h·kPa), ABTS free radical scavenging rate ≥80%; This invention significantly improves the water solubility and stability of astaxanthin through the ternary synergy of polysaccharide-protein-active factors, realizing the integration of multiple functions of anti-oxidation, antibacterial and physical barrier. When applied to grapes for room temperature preservation for 10 days, the weight loss rate is only 20.23%, and the hardness is maintained at 7.87N. The preservation effect is significantly better than commercially available PE film and pure carboxymethyl cellulose film. Moreover, the composite film has good biodegradability and has broad application prospects in the field of food preservation.

The invention relates to a stem cell preparation for treating Parkinson's disease and a preparation method thereof, and belongs to the technical field of biological medicines.The preparation method comprises the following steps that a traditional Chinese medicine extract is encapsulated through solid lipid nanoparticles, ultrasonic treatment is conducted, and a compound substance is obtained; coating the compound with quaternized chitosan and hyaluronic acid, so as to obtain an encapsulated compound; and dispersing neural stem cells in a phosphate buffer solution to obtain a cell suspension, dispersing the encapsulated compound in deionized water to obtain a dispersion liquid, and adding the dispersion liquid into the cell suspension to obtain the stem cell preparation for treating Parkinson's disease. According to the technical scheme, the traditional Chinese medicine extract is doubly encapsulated by the solid lipid nanoparticles, the quaternized chitosan and the hyaluronic acid, so that active ingredients in the traditional Chinese medicine extract can be effectively protected, the biological activity and the stability of the traditional Chinese medicine extract are improved, proliferation and differentiation of stem cells are promoted, and the survival rate of the stem cells is increased. And the stem cell preparation can have a better effect in the aspect of preventing and treating Parkinson's disease.

The invention relates to a method for preparing quercetin liposome, which comprises the following steps: (1) adding phospholipid, cholesterol, phospholipid polyethylene glycol and quercetin into ethanol, and dissolving to obtain an ethanol phase solution; (2) respectively pumping the ethanol phase solution obtained in the step (1) and pure water into a micro-fluidic chip from different channel inlets, and carrying out micro-mixing to obtain a quercetin liposome crude product; and (3) dialyzing the quercetin liposome crude product obtained in the step (2) by using an aqueous medium to obtain the quercetin liposome. The method avoids the use of harmful and expensive organic solvents such as trichloromethane and methanol. Compared with the existing preparation technology in the market, the preparation method disclosed by the invention is higher in safety, more environment-friendly, short in time consumption and more advantageous in production cost.

The invention discloses a method for repairing damage of high-dose gallic acid to the performance of myofibrillar protein gel based on a beta-cyclodextrin metal organic framework. Extracting myofibrillar protein; the preparation method comprises the following steps: preparing a beta-cyclodextrin metal organic framework by taking beta-cyclodextrin and potassium ions as raw materials; mixing the gallic acid solution with the beta-cyclodextrin metal organic framework solution to obtain a gallic acid / beta-cyclodextrin metal organic framework inclusion compound solution; then adding myofibrillar protein for homogenization, then adding a Fenton oxidation system, uniformly mixing and reacting; and heating the reacted myofibrillar protein in a water bath, and cooling to obtain the performance-repaired myofibrillar protein gel based on the beta-cyclodextrin metal organic framework encapsulated gallic acid. The gallic acid is encapsulated by the beta-cyclodextrin metal organic framework, so that excessive aggregation of myofibrillar protein caused by high-dose gallic acid is reduced, more proteins are promoted to participate in formation of an ordered gel network structure, and the myofibrillar protein gel with higher gel strength and water binding capacity is obtained.

The application discloses a tumor microenvironment responsive nano-composite hydrogel co-drug delivery system and a preparation method thereof, and belongs to the field of antitumor materials. The nano-composite hydrogel co-drug delivery system is a sodium alginate hydrogel with hyaluronic acid encapsulated drug-loaded nanoparticles embedded in the interior. The drug-loaded nanoparticles encapsulate anthracycline chemotherapy drugs and tyrosine kinase inhibitors; the anthracycline chemotherapy drugs are connected to the hyaluronic acid side chain through a hydrazone bond to form a polymer prodrug, and the tyrosine kinase inhibitors are encapsulated into the hydrophobic core of the nanoparticles through self-assembly of the polymer prodrug molecules to obtain the hyaluronic acid encapsulated drug-loaded nanoparticles. The sodium alginate hydrogel is a dopamine modified sodium alginate hydrogel. The nano-composite hydrogel co-drug delivery system is easy to be injected intratumorally and paratumorally, can be slowly degraded in the body, and can target and synchronously deliver the drugs to tumor cells by using the escaped nanoparticles, so as to inhibit tumor cell proliferation, invasion and migration, and realize a synergistic antitumor effect.

The present invention discloses an ionizable lipid and a preparation method and application thereof. The structural formula of the ionizable lipid is: Under acidic conditions, the ionizable lipid is positively charged and can be electrostatically attracted to the negatively charged phosphate groups of mRNA. The halogen-containing alkyl group can have better affinity with the membrane. At the same time, the hydroxyl structure is easy to form hydrogen bonds with the bases of the mRNA, thereby achieving a good coupling effect and having a high encapsulation efficiency.

The invention relates to a preparation technology of a compound cooling agent, and relates to the technical field of food additives, and the preparation technology comprises the following steps: mixing and dispersing a cooling agent, a cooling taste improving agent and an emulsifying agent into propylene glycol, and stirring to obtain a cooling agent premix; dispersing a wall material into water, heating and stirring to obtain a wall material solution; adding the cooling agent premix into the wall material solution, and stirring to obtain an emulsified dispersion liquid; and adding the cross-linking agent solution into the emulsified dispersion liquid, adjusting the pH value to be acidic, heating and stirring for reaction, cooling, adding ethanol for precipitation to obtain microcapsules, washing the microcapsules with ethanol, and freeze-drying to obtain the compound cooling agent. The compound cooling agent has the effect of improving the stability of the compound cooling agent, the compound cooling agent has a good cooling effect, and long-acting cooling feeling is provided through slow-release regulation and control.

The invention discloses an automatic packaging device and method for a self-adhesive insulating tape, the automatic packaging device comprises a first transmission part, a packaging part, a guide part, a tape fixing part, a second transmission part and a winding column connected to the second transmission part, and the packaging part, the guide part and the tape fixing part are all connected to the first transmission part; the guide part is located below the packaging part, the adhesive tape fixing part is located on the right side of the packaging part, and the first transmission part can drive the packaging part, the guide part and the adhesive tape fixing part to rotate synchronously; the winding column is connected to the second transmission component, the second transmission component is connected to the first transmission component, and the first transmission component can drive the second transmission component and the winding column to rotate synchronously; the winding column is located below the adhesive tape fixing part, and the automatic packaging device for the self-adhesive insulating adhesive tape is adopted in the automatic packaging method for the self-adhesive insulating adhesive tape.