5results about How to "Improve encapsulation efficiency" patented technology

This invention belongs to the field of fire extinguishing materials and their preparation technology, and provides a fire extinguishing microcapsule and its microfluidic controllable preparation method. The preparation method is characterized by the following steps: (1) preparing fluids of each phase, (2) preparing a dual emulsion using a microfluidic device, (3) collecting and sealing the dual emulsion in a collection container, controlling the axis of the collection container to be horizontal, and controlling the collection container to rotate around its axis for 1 to 15 minutes, applying light to solidify the outer shell of the dual emulsion droplets while maintaining the rotation of the collection container, cleaning, and drying to obtain the final product. The fire extinguishing microcapsule prepared by this method consists of an outer shell and a liquid fluorine-containing fire extinguishing agent encapsulated within the outer shell. The outer shell of the fire extinguishing microcapsule has a uniform thickness, and the eccentricity between the outer shell and the core is less than 0.1. The method of this invention can achieve precise customization of fire extinguishing microcapsules according to the differentiated fire characteristics of different application scenarios, and can improve the concentricity between the core and the outer shell of existing fire extinguishing microcapsules.

The application discloses a multifunctional injectable hydrogel and a preparation method and application thereof, and relates to the technical field of multifunctional hydrogel preparation and application. In the preparation, CMC-AGE and OD-SH are prepared respectively, and DSPE-se-se-PEG@AC NPs nanoparticles are prepared, then the multifunctional injectable hydrogel is prepared by forming a hydrogel through CMC-AGE and OD-SH and adding DSPE-se-se-PEG@AC NPs nanoparticles and / or beta nerve growth factor. The application also includes the multifunctional injectable hydrogel prepared by the above method and the application thereof. The application constructs an in-situ hydrogel delivery platform with good biocompatibility, is used for co-delivery of DSPE-se-se-PEG@AC NPs and NGF, is used in ischemic stroke treatment, and reshapes the pathological microenvironment of a cerebral infarction area, so that cerebral ischemic injury is reduced.

This invention discloses fucoidan-phycocyanin nanoparticles loaded with astaxanthin. The nanoparticles are formed by the self-assembly of fucoidan and phycocyanin through electrostatic interactions and hydrogen bonds to form a carrier, encapsulating astaxanthin within. The nanoparticles have a particle size of 250 nm–350 nm, an absolute zeta potential ≥20 mV, a polydispersity index ≤0.30, and an astaxanthin encapsulation efficiency ≥78%. The composite preservation film uses carboxymethyl cellulose as the film-forming matrix, with the nanoparticles uniformly dispersed therein. The water contact angle is ≥90°, and the water vapor transmission rate is ≤14%. g·mm / (m²·h·kPa), ABTS free radical scavenging rate ≥80%; This invention significantly improves the water solubility and stability of astaxanthin through the ternary synergy of polysaccharide-protein-active factors, realizing the integration of multiple functions of anti-oxidation, antibacterial and physical barrier. When applied to grapes for room temperature preservation for 10 days, the weight loss rate is only 20.23%, and the hardness is maintained at 7.87N. The preservation effect is significantly better than commercially available PE film and pure carboxymethyl cellulose film. Moreover, the composite film has good biodegradability and has broad application prospects in the field of food preservation.

The invention discloses a method for repairing damage of high-dose gallic acid to the performance of myofibrillar protein gel based on a beta-cyclodextrin metal organic framework. Extracting myofibrillar protein; the preparation method comprises the following steps: preparing a beta-cyclodextrin metal organic framework by taking beta-cyclodextrin and potassium ions as raw materials; mixing the gallic acid solution with the beta-cyclodextrin metal organic framework solution to obtain a gallic acid / beta-cyclodextrin metal organic framework inclusion compound solution; then adding myofibrillar protein for homogenization, then adding a Fenton oxidation system, uniformly mixing and reacting; and heating the reacted myofibrillar protein in a water bath, and cooling to obtain the performance-repaired myofibrillar protein gel based on the beta-cyclodextrin metal organic framework encapsulated gallic acid. The gallic acid is encapsulated by the beta-cyclodextrin metal organic framework, so that excessive aggregation of myofibrillar protein caused by high-dose gallic acid is reduced, more proteins are promoted to participate in formation of an ordered gel network structure, and the myofibrillar protein gel with higher gel strength and water binding capacity is obtained.

The application discloses a tumor microenvironment responsive nano-composite hydrogel co-drug delivery system and a preparation method thereof, and belongs to the field of antitumor materials. The nano-composite hydrogel co-drug delivery system is a sodium alginate hydrogel with hyaluronic acid encapsulated drug-loaded nanoparticles embedded in the interior. The drug-loaded nanoparticles encapsulate anthracycline chemotherapy drugs and tyrosine kinase inhibitors; the anthracycline chemotherapy drugs are connected to the hyaluronic acid side chain through a hydrazone bond to form a polymer prodrug, and the tyrosine kinase inhibitors are encapsulated into the hydrophobic core of the nanoparticles through self-assembly of the polymer prodrug molecules to obtain the hyaluronic acid encapsulated drug-loaded nanoparticles. The sodium alginate hydrogel is a dopamine modified sodium alginate hydrogel. The nano-composite hydrogel co-drug delivery system is easy to be injected intratumorally and paratumorally, can be slowly degraded in the body, and can target and synchronously deliver the drugs to tumor cells by using the escaped nanoparticles, so as to inhibit tumor cell proliferation, invasion and migration, and realize a synergistic antitumor effect.