84results about How to "Overcome the conditions" patented technology

The invention discloses a preparation method of magnetic / gold nano particles. The preparation method comprises the following steps: firstly adopting a co-precipitation method to prepare the magnetic Fe3O4 nano particles; polymerizing the dopamine in-situ on the surfaces of the magnetic particles to obtain Fe3O4 nano particles modified by the poly dopamine; introducing polyphenol and amino groups to the surfaces of the Fe3O4 nano particles; absorbing the nano gold seeds on the surfaces of the modified magnetic particles through the static action; adopting the nano gold which is absorbed on the surfaces of the magnetic particles as the seed, adopting the polyphenol on the surfaces of the magnetic particles as a reducing agent, gradually adding the chloroauric acid liquid to gradually produce the gold layers on the surfaces of the magnetic particles to obtain the core-shell magnetic / gold nano particles. The nano particles have good water dispersion and strong magnetic respond performance. The diameters of the nano particles are 30-100 nanometers, the saturation magnetization is 30.1-38.7emu / g, and the nano particles are superparamagnetic. The nano particles have wide application prospect on the fields of targeted drug controlled release, thermal therapy, separation of protein and enzyme, etc.

The invention relates to an urban air quality grade predicting method based on multi-field characteristics. The method comprises a data preprocessing stage, a training stage and a predicting stage. In the data preprocessing stage, mesh generation is carried out to obtain a training sample, and a training data set is obtained. In the training stage, the optimal parameter of a conditional random field model is estimated, an optimal model shown in the specification is obtained, and the conditional random field model is output. In the predicting stage, the maximum output sequence, shown in the specification, of the conditional probability P(Y / X<f>) is obtained by combining the viterbi algorithm and the conditional probability model shown in the specification and obtained in learning of the training stage, and a prediction result is output. The AQI grade can be predicted more accurately, the AQI grade prediction in the following time quantum of all stations is carried out, and the requirement for selecting the time quantum with the high air quality to go out and take activities of people is met.

The invention relates to a simple and easy preparation method for super-hydrophobic fiber and textile with high contact angle and low rolling angle and application thereof. Surface chemical modification is directly carried out on intrinsic coarse structures on the surface of the fiber and textile so as to prepare a fiber product with super-hydrophobic performance; the method comprises the following steps of: firstly, cleanly washing materials, then carrying out isocyanate modification on the material, and finally modifying low surface energy material. The raw material is cheap and is easily available; reaction conditions are relatively mild; the operation is simple; and the requirement on the device is low. The obtain product has good super-hydrophobic performance; the contact angle of 10microliter of water is 156 degrees; and the product has wide application in fields of self-cleaning fibers and textiles.

The invention belongs to the technical field of synthesis and preparation of polymer materials, and discloses a synthetic method of triblock polymer, wherein stepwise polymerization (SGB), atom transfer radical polymerization (ATRP) and click chemistry method are combined at first; and 1, 3-dipolar cycloaddition reaction is performed to polymer with azido terminal group and polyurethane prepolymer with alkynyl terminal group to successfully synthesize triblock polymer containing triazole ring. The synthesis method provided by the invention overcomes the defects in traditional block polymer synthesis that reaction conditions are strict, molecular weight distribution is controlled difficultly, and selectable classes of monomers are less, and has the advantages of high conversion rate, mild reaction conditions, narrow molecular weight distribution and strong controllability. The triblock polymer provided by the invention has potential application in ways of medicine slow release, solubilizers and surfactants.

The invention discloses a method for preparing a porous polymer micro needle by using a template method and an application thereof. The method comprises the following steps of: (1) dissolving a polymer and a template agent in a solvent to prepare a polymer solution; (2) filling the polymer solution into a micro needle mould; (3) removing the solvent in the obtained micro needle mould to obtain a solid micro needle; (4) removing the template agent in the obtained solid micro needle to obtain the porous polymer micro needle. By improving the overall process flow design of the preparation method,the method can solve the technical problems of a complex preparation process, harsh conditions, a complicated process, high price, difficult control of the pore structure and size, difficult large-scale production and application and the like of the porous polymer micro needle, the obtained porous polymer micro needle can be used for tissue fluid extraction and transdermal administration, such asskin tissue fluid and blood extraction and transdermal administration of proteins, polypeptides and small molecular drugs in cosmetic, hair growth, immunity, treatment and other applications.

The invention discloses a calculation method for dynamic reserves of gas reservoir. The calculation method aiming at solving the problems that an existing gas reservoir dynamic reserve calculation method is lack of information, harsh in use conditions or complicated in analysis process, the calculation method is based on the advantages of a material balance method and is combined with the gas seepage process, a vertical pipe flow model, a gas well productivity equation and a material balance equation. The calculation method comprises the following steps that S1, production dynamic data are prepared; S2, the bottom hole flowing pressure is calculated, specifically, the bottom hole flowing pressure of a gas well is calculated according to the processed production dynamic data of the gas well; S3, the formation static pressure is calculated, specifically, a binomial deliverability equation of the gas well is adopted to calculate the average formation pressure of the gas well; S4, flow stages are divided, specifically, a boundary control flow stage, an unstable flow stage and a transition stage are determined; and S5, the dynamic reserves are calculated, specifically, the dynamic reserves after the unstable flow stage of the gas well is finished is calculated, and the dynamic reserves is added to the cumulative gas production in the unstable flow stage to get the true dynamic reserves of the gas well.

The invention provides an arch bridge cantilever assembling construction optimization calculation method. An actual line shape and a target line shape in each construction lifting stage are strictly controlled, so that the preraised height value of each control node is changed mildly, the cable force uniformity is good, and the stress concentration phenomenon of a material in a construction process does not occur. An arch bridge cantilever assembling construction optimization model has the advantage of relatively few constraint conditions; the constraint condition that a deviation between theline shape after cable tightening and release, and the target line shape is in an allowed range mainly achieves a constraint control effect; and the problems of large buckling cable force gradient, poor uniformity and the like during adoption of a conventional method for performing construction optimization calculation are solved.

An activating grinding aid for industrial waste residues is prepared from catalyst (1-8 wt.%), activating agent (30-80 wt.%), setting regulator (0-20 wt.%), grinding aid (3-12 wt.%) and carrier (3-30wt.%). Its advantages are effective use of industrial waste residues, low electric consumption of grinder, and improve cement performance.

The invention discloses a self-cleaning superhard polysilazane hydrophobic coating and a preparation and use method thereof, and belongs to the technical field of super-hydrophobic coatings. The self-cleaning superhard polysilazane hydrophobic coating is prepared from the following components in parts by weight: 5 to 25 parts of organic-inorganic hybridized polysilazane, 15 to 30 parts of hydrophobic acrylate resin, 5 to 15 parts of nanometer silicon dixoide and 40 to 250 parts of organic solvent. The self-cleaning superhard polysilazane hydrophobic coating has the advantages that the excellent superhard, super-hydrophobic, scratch-resistant, abrasion-resistant and high-adhesion properties of a coating are realized; the defects of easiness in cracks, voids and the like in the inorganic polysilazane coating along with the increase of coating thickness are overcome; the problem of low hardness of the organic polysilazane is solved; the coating has the advantages that the hardness is high, the adhesion force is high, the easiness in falling and cracking of the coating is avoided, and the abrasion-resistant and scratch-resistant properties of the coating are ensured; the preparation technology is simple, the implementing is easy, and the preparation technology is suitable for widely popularized and applied.

The invention discloses a river plane two-dimension current model roughness calibration method comprising the following steps: 1, delimiting roughness zones according to river plane features, and initializing the roughness in each zone; selecting the present flow rate with to-be-calibrated roughness and the corresponding river reach outlet water level; using a river plane two-dimension current mathematics model to carry out water-power calculation; determining errors between a model calculated value and an actual measurement value of each monitoring point water level; determining whether the water level error is small enough or not; determining a water pass area according to the water depth, and using all monitoring point water level error interpolation to estimate the water level errors between all grid points in the water pass area; using a dichotomy to adjust the roughness of the grid points in the water pass area according to the water level errors of all grid points in the water pass area; further determining whether all to-be-calibrated flow rates have been calibrated or not; if yes, finishing roughness calibration, and storing the roughness calibration result. The method can reduce artificial interferences in an iteration trial process, thus solving the problems that an existing method is unclear in technical process, rigid in conditions, and hard to apply.

The invention relates to a method used ion liquid to process office waste paper de-inking de-coloring. It can solve the problems of pollution and unable reclaiming for the de-inking drugs. The ion liquid can be reclaimed to utilize circularly, which can save cost. The microwave heating device is simple, cheap, has moderate, non-toxic, and harmless operation condition.

The invention discloses a guyed traveler for a cable-stayed bridge. The guyed traveler comprises a front half portion and a rear half portion which can be assembled together to be in a B-shaped frame structure. The front half portion comprises a pair of parallel main longitudinal girders and a front cross girder and a middle cross girder which are arranged between the main longitudinal girders; and the rear half portion comprises a pair of parallel tail longitudinal girders and a rear cross girder which is arranged close to the rear ends of the tail longitudinal girders. An assembly method for the guyed traveler comprises mounting a supporting frame through a cable bent tower lower cross girder, building a girder 0-1# on the supporting frame, mounting a traveler assembly platform by using a temporary cable reserved on a tower column, assembling the front half portion of the traveler, and pouring a girder 0-2#; dropping the front half portion of the traveler, pushing and moving the front half portion forwards on the platform, and assembling the rear half portion of the traveler; and lifting the assembled traveler integrally, and anchoring and connecting the assembled travel with the girder 0-2#. According to the guyed traveler for the cable-stayed bridge and the assembly method for the guyed traveler, the construction is simple and convenient, costs are reduced, and safety risks are low.

The invention relates to a method for producing alumina from bauxite. The method adopts sodium hydroxide solution in high molecular ratio, can efficiently extract alumina from indissolvable-diasporite type bauxite at low temperature under the normal / low pressure, is mild in operation conditions, and has actual dissolution rate up to over 90 percent. After stripped slag-containing suspension is subjected to flash evaporation cooling to crystallize and precipitate sodium aluminate hydrate crystals, the sodium aluminate hydrate crystals are dissolved in water or dilute alkali solution and then subjected to desilication, seed precipitation and calcination so as to obtain alumina meeting the requirements of metallurgical grade. Slag is dealuminized through sodium aluminate hydrate crystallization mother liquor and then is subjected to sodium removal so as to effectively reduce the content of sodium oxide and alumina in red mud, enable the composition, alkali content and other main indexes of obtained red mud physical phase to meet the requirements of raw materials for producing cement, reduce the loss amount of alkali solution and raise the resource utilization rate of bauxite. Dealuminized stripping solution can be recycled for stripping bauxite, so that industrial operability is greatly improved.

The invention provides a vehicle license plate detection and recognition method based on combination of MSER and SWT. TO reduce influence of a shooting angle and illumination on license plate recognition and improve the license plate recognition accuracy rate under a complicated background, the method first performs MSER extraction and Canny edge detection, and performs MSER screening after an intersection of MSER extraction and Canny edge detection is taken according to license plate character characteristics; then SWT based on morphological processing is performed in areas after screening, areas after screening are aggregated, and combined with geometrical characteristics of a license plate, fine positioning of the license plate is completed; finally, segmentation correction is performedon connected domains in a successfully positioned area, a framework is extracted and normalization is performed, and the framework after normalization is matched with a template after refining and normalization; and HU invariant moment and grid characteristics are utilized to recognize the Chinese character of the first character, and jump point scanning, statistics and encoding are adopted to recognize numbers and letters. The vehicle license plate detection and recognition method provided by the invention has relatively a high accuracy rate and robustness of license plate detection and recognition obtained under a complicated background at multiple angles and under variable illumination conditions.

The invention relates to a method of preparing vegetable oil polylol by using natural renewable resources. Epoxy soybean oil, a solvent, methanol, water and a catalyst are added performed autoclave, wherein, the proportion by weight of the epoxy soybean oil, the solvent, anhydrous methanol, water and the catalyst is 10:1 to 10:1 to 12:1 to 6:1 to 4, the reaction temperature ranges from 100 DEG C to 160 DEG C, and the optimized temperature ranges from 120 DEG C to 160 DEG C. The reaction pressure is self pressure, and the reaction is completed after reacting for 12 to 20 hours through stirring. The method has the advantages of no pollution, simple processing procedure after the reaction, and mild reaction conditions.

The invention relates to a nano-composite air electrode catalyst for a zinc-air battery and a preparation method of the nano-composite catalyst, belonging to the technical field of zinc-air batteries. The nano-composite catalyst is composed of manganese dioxide, nano-silver, a carbon nano tube and a carbon material in the mass ratio of (0-0.5) to (0-0.5) to 1 to (1.75-2.75), wherein the mass of manganese dioxide and the mass of nano-silver cannot be zero at the same time. Due to the addition of nanometer materials such as nano-silver and the carbon nano tube, the wettability of the nano-composite catalyst is improved, and the reduction reaction of oxygen in a three-phase boundary formed by electrolyte, catalyst material and oxygen is facilitated; meanwhile, the composite catalyst formed by manganese dioxide and nano-silver has oxygen reduction effect higher than that of a single catalyst. The nano-composite catalyst adopts the preparation technology comprising the steps of pretreatment, granulation, ultrasonic dispersion and ball-milling treatment, the operation is simple and efficient, and the application prospect is good.

The invention belongs to the technical field of biological materials, and discloses a hydrogel material for 3D bioprinting and a preparation method and application of the hydrogel material. The hydrogel material comprises the following components in percentages by mass: 0.5-10% of gellan gum and / or derivatives, 0.1-20% of PEG and / or derivatives thereof, 0-1% of a crosslinking initiator, 0-15% of biologically active components and the balance of a solvent. The hydrogel material is double-network hydrogel based on the gellan gum and PEG; interpenetrating double-network structures are formed in a physiological environment; and the hydrogel material has good structure and dimensional stability, and has the advantages of quick gum formation under physiological conditions, excellent cell compatibility, small immunological rejection, high cell encapsulation efficiency, controllable mechanical strength, biodegradability and the like. The hydrogel material is applied to 3D bioprinting; the shortcomings of low curing speed, harsh curing conditions, limited mechanical properties, poor cell compatibility and the like are overcome; and the hydrogel material has obvious advantages and good industrialized prospect.

Relating to the soil remediation field, the invention discloses a preparation for in-situ remediation of chlorothalonil contaminated soil. The preparation contains fungi and / or bacteria with chlorothalonil degradation ability. The fungi can be at least one of Aspergillus niger, rhizomucor variabilis and Cunninghamella bertholletiae, and the bacteria can be at least one of Burkholderia zhejiangensis, pseudomonas aeruginosa and Stenotrophomonas maltophilia. According to the invention, the provided preparation is employed for in-situ bioremediation of chlorothalonil contaminated soil, not only overcomes the problems that photochemical degradation is easily limited by illumination conditions and can easily cause secondary chemical reagent pollution to arable land, at the same time makes full use of fungi and / or bacteria for catabolism of chlorothalonil residual in soil, thus solving the problem that high residual chlorothalonil in soil severely endangers food safety. At the same time, the micro-ecology of soil is improved, so that soil can recover farming ability more rapidly. Also, the method is low in cost, thus having broad application prospects.

The invention discloses a true triaxial test method of simulating an extensional rock burst. The method employs a true triaxial loading route and a boundary condition of single side freeness and five side stressing, and utilize a cuboid rock sample in a single side freeness and three directional compressive stress state to simulate a special mechanical behavior of a representative rock unit of field wall rock in a tangential stress concentration process by applying a certain three directional load and controlling a loading speed of one direction. The method can be used for representing a whole inoculation and occurrence process of the extensional rock burst in a laboratory. The method solves the problem that the traditional indoor test method cannot simulate the extensional rock burst under a complex stress condition reasonably and has important practical significance and academic value in promoting mechanism and prediction studies of the rock burst.

The invention discloses an immobilized porcine pancreatic lipase carrier, which is a macroporous bead crosslinked polymer containing succinimidyl ester groups and has a structure represented by the formula I. The carrier forms a high polymer with acrylic acid as a reactive monomer and N,N'-methylenebisacrylamide as a crosslinking agent, and in the meantime, incorporates the succinimidyl ester active group so that the time required for immobilizing the porcine pancreatic lipase is short, namely only 1 hour is required, and the immobilizing efficient is high and stability of activity retention of the immobilized enzyme is excellent; the apparent activity of the immobilized enzyme is high and can reach 750U / g and above. The invention also discloses a preparation method and application of the immobilized porcine pancreatic lipase carrier.

The invention discloses a roxburghanoectochilus factory cultivation method and cultivation module. The roxburghanoectochilus factory cultivation method comprises following steps: 1) After being washed and sterilized, the roxburghanoectochilus bud is transplanted on a cultivation board; the cultivation board is arranged in a cultivation tank; a nutrient solution flowing in the cultivation tank is provided; the nutrient solution adopts a nutrient liquid membrane technique and the liquid membrane is 0.7 centimeter-1.3 centimeter; only new root of the roxburghanoectochilus bud is immersed in nutrient solution. 2) The roxburghanoectochilus terminal bud is transplanted to the cultivation board for 2 days of dark adaptation. 3)After the dark adaptation, the roxburghanoectochilus terminal bud is irradiated by shot photoperiod for 3 days. 4) Then regular light cycle exposure for the roxburghanoectochilus bud which has been irradiated by shot photoperiodis performed.

The invention relates to the clone of amidohydrolase, and the construction, zymoprotein expression and industrial application of engineering bacteria, belongs to the field of bioengineering technology and mainly aims to solve the problems that amidohydrolase produced by natural bacteria is low in enzyme activity, low in bacterial concentration and difficult for production application. On the basis that the hydrolase is produced by fermenting Delftiatsuruhatensis in Delftia, an amidohydrolase gene is cloned to establish a full set of process of the fermentation, and inducible expression, and industrial production of the Escherichia coli gene engineering bacteria. Through the gene engineering modification, the amidase activity is over 3000 u / l, much higher than 300 u / l of the original strain; the actual application shows that the enzyme has a wide application scope, can be applied the production of side chains of statins, the production cost is greatly reduced and the realization of green chemistry is promoted.

The invention discloses a method for detecting heavy metals in plastics. The method comprises the following steps: S1. putting the plastics to be detected in an airtight container filled with an organic solvent, and carrying out ultrasonic oscillation in a water bath to dissolve the plastics, thus obtaining a plastic dissolution solution; S2. adding dilute nitric acid to the plastic dissolution solution, carrying out ultrasonic oscillation at room temperature, and carrying out filtration, washing and constant volume achievement to extract heavy metals in the plastic dissolution solution, thus obtaining a solution to be detected, containing the organic solvent; S3. qualitatively and quantitatively analyzing the heavy metals in the solution to be detected by adopting an inductively coupled plasma optical emission spectrometer (ICP-OES). The method has the beneficial effects that by utilizing the characteristic that the plastics have better solubility in the organic solvent, the plastics are dissolved by using the proper organic solvent, and then the heavy metals in the plastics are extracted to form the solution to be detected, containing the organic solvent; then the heavy metals dissolved in the organic solvent are qualitatively and quantitatively analyzed by adopting the ICP-OES. The method has the advantages of simple and fast operating process, mild reaction conditions, accuracy in detection, high recovery rate and good stability and is suitable for mass treatment.

The invention relates to proanthocyanidin sustained release nano-micro spheres. The proanthocyanidin sustained release nano-micro spheres comprise 1-5 parts of proanthocyanidin, 1-12 parts of chitosan or derivatives thereof, 1-12 parts of phospholipid or derivatives thereof and 1-10 parts of excipients, wherein the chitosan and the derivatives thereof are one or more of high, medium and low-molecular weight chitosan, chitosan oligosaccharide, chitosan quaternary ammonium salt and carboxymethyl chitosan. The particle size of the proanthocyanidin sustained release nano-micro spheres is 10nm-0.3 mu m; the proanthocyanidin is prepared into the powder sustained release nano-micro spheres, and the proanthocyanidin sustained release nano-micro spheres can directly play a role in the lung as a pulmonary inhalation medicine-carrying formulation, improve the bioavailability of the proanthocyanidin and reduce the dosage by sustained release; the proanthocyanidin nano-micro spheres can also be applied as an oral sustained release formulation; the proanthocyanidin nano-micro spheres have appropriate particle size and morphology and other powder properties, as well as sustained release; furthermore, the preparation method has the advantages of simplicity and convenience in operation, stable process and easiness in industrial production.

The invention discloses a water level monitoring method, and solves the technical problems that an existing water level monitoring method is easily affected by lights and the water level monitoring error is large; the method comprises the following steps: gathering mark post and water surface images; using the features that the mark post is small in brightness change and the water surface brightness continuously changes caused by changing ripples, and using an image processing technology to read the gray values of two images with the adjacent taken time; making difference calculations, and drawing a relation graph between difference gray average variance yields and coordinates for the water surface in the image; using a threshold segmentation algorithm to obtain the coordinates corresponding to the gray average variance mutation moment, i.e., the water surface coordinates; combining a statistic method to smoothen the water surface coordinates; finally, calculating the water level depthaccording to the mapping relation between the mark post real lengths and the image coordinates. The method can accurately determine the water level position, can monitor the water depth in real time,and has very well robustness and timeliness.

The invention is an analyzing method for 2-ketone-L-gulong acid content. Its character lies in: the 2-ketone-L-gulong acid has redox reaction to metal weak oxidant, the excess metal weak oxidant oxidizes negative iodide ion into iodine, carries on titration to iodine generated in the solution with thiosulfate standard solution, works out the real weight of gulong acid in sample according to the chemical proportion in the reaction, thus measures the content percentage of gulong acid in sample. The merits of the invention lie in: 1) it solves the problem that the repetiliveness of data is bad with current technology to measure the content; 2) overcomes the complexity, hard and long period of HPLC; 3) it is accurate, the error is small, the operation is simple, and the material is cheap.

The invention discloses a forced oscillation disturbance source identification and splitting method based on an oscillation starting characteristic and belongs to the technical field of emergency adjustment and control in an electric power system. According to the method, the oscillation starting characteristic of forced oscillation and a disturbance source location energy function method are combined, the correct position is identified from a plurality of suspected disturbance source areas, and if the disturbance source area meets the condition of electric energy supply and demand balance and no island exists in the non-disturbance source areas, a connection fracture surface line between the area where a disturbance source is located and a system can be split; otherwise, the identified area where the disturbance source is located serves as an initial island, adjacent nodes of the island are searched for, and the connection fracture surface is adjusted till the requirement for electric energy supply and demand balance is met and the condition that power grids remaining after splitting are connected is met. The method solves the problem about positioning of the disturbance source in forced oscillation control. Through the method, splitting control measures can be given in real time when oscillation is detected, and the method has great significance in suppressing oscillation and guaranteeing stable running of interconnected electric power systems.

The invention discloses a bending fretting fatigue test device for a dropper of a high-speed railway catenary, which comprises a dropper fixing end, a force compensating end, a fatigue load loading part and a data acquisition and processing unit. One end of a dropper sample is fixed on a support of the fixing end, and the other end is fixed on a support of the force compensating end. A pre-tightening force is applied to the dropper by a force compensating spring. The middle part of the dropper is connected to a fatigue test machine through a loading rod. During the whole test, the bending fretting fatigue test of the dropper with variable parameters and multiple working conditions is carried out by controlling the fatigue test machine after the pressure of the fixing end and the pre-tightening force of the dropper are set.

The invention provides a method for catalyzing hydrodeoxygenation to prepare hydrocarbon through guaiacol. Mixtures of guaiacol and alcohol are used as raw materials, under the catalytic action of a HZSM-5 molecular sieve at the temperature of 500 to 600 DEG C, the raw materials are added into a fixed bed reactor through a peristaltic pump to generate a gas-solid catalytic cracking reaction, the reaction is conducted continuously for 0.5 to 1 h while the temperature is maintained after raw material adding is completed, condensation treatment is conducted on a reaction product through a condenser pipe in the reacting process, condensed fluid and non-condensable gases are collected respectively, stewing and layering are conduced on a condensed fluid product, aqueous phase and oil phase are collected respectively, and a product namely the hydrocarbon substance is in the oil phase; the alcohol is one of n-butyl alcohol, n-amyl alcohol or hexyl alcohol. The preparation method has the advantages that the reaction condition is mild, the equipment is normal and simple, the service life of catalyst is long, the production cost is low, and the preparation method is suitable for industrial production; the conversion rate of the guaiacol reaches up to 100%, the recovery rate of the hydrocarbon substance reaches up to 20.68%, the moisture content of the oil phase is 1.37%, the calorific value reaches up to 40882J / g, and the oil phase quality is high.

The invention discloses a method for preparing a porous polymer microneedle based on a phase separation technology and application of the method. The method comprises the following steps that 1, a polymer is dissolved into a solvent A to obtain a polymer solution; 2, the polymer solution is put into a microneedle mould; 3, the microneedle mould is placed in a poor solvent B, so that phase separation of the polymer in the microneedle mould is facilitated; 4, the poor solvent B is removed, and then the porous polymer microneedle can be obtained. Through the simple and mild phase separation technology, the porous polymer microneedles can be prepared on a large scale, and therefore, the technical problems can be solved that the preparation process of the porous polymer microneedle is complicated, the conditions are harsh, the technology is tedious, the price is high, the pore structure, the size and the distribution are difficult to control, and it is difficult for large-scale production and application. The prepared porous polymer microneedle can be used for interstitial fluid extraction and transdermal drug delivery.