Proanthocyanidin sustained release nano-micro spheres, as well as preparation method and application thereof

Abstract

The invention relates to proanthocyanidin sustained release nano-micro spheres. The proanthocyanidin sustained release nano-micro spheres comprise 1-5 parts of proanthocyanidin, 1-12 parts of chitosan or derivatives thereof, 1-12 parts of phospholipid or derivatives thereof and 1-10 parts of excipients, wherein the chitosan and the derivatives thereof are one or more of high, medium and low-molecular weight chitosan, chitosan oligosaccharide, chitosan quaternary ammonium salt and carboxymethyl chitosan. The particle size of the proanthocyanidin sustained release nano-micro spheres is 10nm-0.3 mu m; the proanthocyanidin is prepared into the powder sustained release nano-micro spheres, and the proanthocyanidin sustained release nano-micro spheres can directly play a role in the lung as a pulmonary inhalation medicine-carrying formulation, improve the bioavailability of the proanthocyanidin and reduce the dosage by sustained release; the proanthocyanidin nano-micro spheres can also be applied as an oral sustained release formulation; the proanthocyanidin nano-micro spheres have appropriate particle size and morphology and other powder properties, as well as sustained release; furthermore, the preparation method has the advantages of simplicity and convenience in operation, stable process and easiness in industrial production.

Description

technical field

[0001] The invention relates to a sustained-release nano-microsphere, in particular to a proanthocyanidin sustained-release nano-microsphere and its preparation method and application, and belongs to the technical field of biomedicine-carrying dosage forms. Background technique

[0002] Oligomeric Proantho Cyanidins (OPC), a bioflavonoid with a special molecular structure, is internationally recognized as the most effective natural antioxidant for removing free radicals in the human body. The anti-free radical oxidation ability of OPC is 50 times that of vitamin E and 20 times that of vitamin C, and it can be absorbed quickly and completely. It can reach the highest blood level in 20 minutes after oral administration, and its metabolic half-life can reach 7 hours. Proanthocyanidins have the functions of protecting cardiovascular, preventing and treating cancer, protecting skin, anti-allergy, anti-inflammation, treating eye diseases, and protecting teeth. How...

Images