Method for preparing porous polymer microneedle based on phase separation technology and application of method

A porous polymer and phase separation technology, applied in the directions of microneedles, medical preparations with non-active ingredients, needles, etc., can solve the problems of harsh conditions, difficulties, complicated processes, etc., and achieve regular pore structure, uniform pore size, and flexibility good control effect

Active Publication Date: 2019-08-13
武汉楚颜生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Wherein by improving the overall process flow design of the preparation method, and the conditions and parameters of the key phase separation steps (such as the composition of poor solvent B and the solubility of the polymer in solvent B, etc.), by filling the polymer solution into In the microneedle mold, the porous polymer microneedle is obtained by inducing phase separation through a poor solvent, and the porous polymer microneedle can be prepared on a large scale through a simple and gentle phase separation technique, which can solve the problem of porous polymer microneedle preparation The process is complicated, the conditions are harsh, the process is cumbersome, the price is expensive, the pore structure, size and distribution are difficult to control, and the large-scale production and application are difficult. The obtained porous polymer microneedles can be used for interstitial fluid extraction and transdermal drug delivery, such as tissue fluid, blood extraction, and transdermal administration of proteins, polypeptides, and small molecule drugs in applications such as cosmetology, hair growth, immunity, and treatment; The temperature of the separation process is optimized and controlled), so that the prepared porous polymer microneedles have a porous structure with good pore size and distribution controllability

Method used

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  • Method for preparing porous polymer microneedle based on phase separation technology and application of method
  • Method for preparing porous polymer microneedle based on phase separation technology and application of method
  • Method for preparing porous polymer microneedle based on phase separation technology and application of method

Examples

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Embodiment 1

[0051] A porous polymer microneedle array prepared by phase separation technology is prepared according to the following method: first, a PDMS (polydimethylsiloxane) negative mold is obtained by using a microneedle positive mold through a reverse replication method, and the negative mold is placed on the After soaking in dimethyl sulfoxide for 2 hours, take it out, remove excess dimethyl sulfoxide on the surface of the female mold (the dimethyl sulfoxide in the concave part of the female mold can not be removed; for example, filter paper can be used to wipe the surface of the female mold , the dimethyl sulfoxide in the depression of the female mold can not be completely removed like this); Then, the molecular weight is 10k, and the dimethyl sulfoxide solution of cellulose acetate that the mass fraction is 30wt% is added dropwise on the female mold, Put it in a beaker with dimethyl sulfoxide, put it in ultrapure water at 25°C after ultrasonication for 1 hour to make the phase se...

Embodiment 2

[0055] A porous polymer microneedle array prepared by phase separation technology is prepared according to the following method: first, use a microneedle positive mold to obtain a PDMS negative mold by reverse replication, and soak the negative mold in dimethyl sulfoxide for 2 hours Finally, take it out, and remove excess dimethyl sulfoxide on the surface of the female mold; then, drop the dimethyl sulfoxide solution of racemic polylactic acid with a molecular weight of 1000k and a mass fraction of 25wt% onto the female mold, and place In a beaker with dimethyl sulfoxide, place in ultrapure water at 25°C after ultrasonication for 1 hour to cause phase separation of the polymer, and freeze-dry after peeling to obtain porous racemic polylactic acid microneedles.

Embodiment 3

[0057] A porous polymer microneedle array prepared by phase separation technology is prepared according to the following method: first, use a microneedle positive mold to obtain a PDMS negative mold by reverse replication, and soak the negative mold in dimethyl sulfoxide for 2 hours Finally, take it out, remove excess dimethyl sulfoxide on the surface of the female mold; then, drop the dimethyl sulfoxide solution of polyarylsulfone with a molecular weight of 800k and a mass fraction of 35wt% onto the female mold, and place it in the presence of dimethyl sulfoxide. In a sulfoxide-based beaker, the polymer was placed in ultrapure water at 25°C after ultrasonication for 1 hour to cause phase separation of the polymer, and then freeze-dried to obtain porous polyarylsulfone microneedles.

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Abstract

The invention discloses a method for preparing a porous polymer microneedle based on a phase separation technology and application of the method. The method comprises the following steps that 1, a polymer is dissolved into a solvent A to obtain a polymer solution; 2, the polymer solution is put into a microneedle mould; 3, the microneedle mould is placed in a poor solvent B, so that phase separation of the polymer in the microneedle mould is facilitated; 4, the poor solvent B is removed, and then the porous polymer microneedle can be obtained. Through the simple and mild phase separation technology, the porous polymer microneedles can be prepared on a large scale, and therefore, the technical problems can be solved that the preparation process of the porous polymer microneedle is complicated, the conditions are harsh, the technology is tedious, the price is high, the pore structure, the size and the distribution are difficult to control, and it is difficult for large-scale production and application. The prepared porous polymer microneedle can be used for interstitial fluid extraction and transdermal drug delivery.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a method for preparing porous polymer microneedles based on phase separation technology and the porous polymer microneedles obtained by the method are used in the preparation of preparations for extracting interstitial fluid or blood Or in the preparation of pharmaceutical preparations for transdermal administration, the preparation method is especially suitable for the preparation of porous polymer microneedle arrays. Background technique [0002] Microneedle is a three-dimensional array structure made of silicon, metal, and polymer, with a length of 25-2000 μm and a tapered tip. Microneedle is a new type of minimally invasive drug delivery tool in the field of biomedicine, which can enhance the effect of skin drug delivery through the epidermis and dermis of the skin. In recent years, microneedles have attracted widespread attention in the field of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/38A61P17/16A61P17/00A61P3/10A61P17/06A61P17/14A61P35/00
CPCA61K9/0021A61K47/34A61K47/38A61M37/0015A61M2037/0046
Inventor 朱锦涛柳佩张连斌
Owner 武汉楚颜生物科技有限公司
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