Composite liposome of vitaminaacid as well as preparation method and application
A compound lipid and retinoic acid technology, applied in the field of pharmacy, can solve the problems of limited container volume, difficulty in taking out, affecting drug release, etc., and achieve the effect of easy control and simple operation
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Embodiment 1
[0028] Embodiment 1 retinoic acid and licorice flavone composite liposome 1
[0029]Recipe: 1g of retinoic acid, 1.5g of glycyrrhizic acid, 4g of soybean lecithin (phosphorylcholine content 80%), 0.5g of Tween 60, 0.01g of di-tert-butyl-p-cresol, 40g of ethanol (85%), PBS solution (0.1 mol / L, pH7.2) 153g.
[0030] Preparation method: add retinoic acid, glycyrrhizic acid, soybean lecithin, Tween 60, and di-tert-butyl-p-cresol into ethanol, and stir until completely dissolved; pour the solution into PBS solution and mix evenly to obtain the complex liposome suspension solution.
Embodiment 2
[0031] Embodiment 2 retinoic acid and licorice flavone compound liposome 2
[0032] Recipe: Retinoic acid 1g, trisodium glycyrrhizinate 1.5g, soybean lecithin (phosphorylcholine content 80%) 4g, 0.5g Tween 60, di-tert-butyl-p-cresol 0.01g, ethanol (80%) 40g, PBS solution (0.1mol / L, pH7.2) 153g.
[0033] Preparation method: Add retinoic acid, trisodium glycyrrhizinate, soybean lecithin, Tween 60, and di-tert-butyl-p-cresol into ethanol, stir until fully dissolved; pour the solution into PBS solution and mix well to form liposomes suspension solution.
Embodiment 3
[0034] Embodiment 3 retinoic acid and licorice flavone compound liposome 3
[0035] Formula: Retinoic acid 1g, glycyrrhetinic acid 1.5g, soybean lecithin (phosphorylcholine content 85%)
[0036] 4g, 0.5g Tween-60, 0.01g di-tert-butyl-p-cresol, 40g ethanol (75%), 153g PBS solution (0.1mol / L, pH7.2).
[0037] Preparation method: add retinoic acid, glycyrrhetinic acid, lecithin, Tween 60, and di-tert-butyl-p-cresol into ethanol, and stir until completely dissolved; pour the solution into PBS solution and mix evenly until the mixture of liposomes suspension solution.
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