Composite liposome of vitaminaacid as well as preparation method and application

A compound lipid and retinoic acid technology, applied in the field of pharmacy, can solve the problems of limited container volume, difficulty in taking out, affecting drug release, etc., and achieve the effect of easy control and simple operation

Inactive Publication Date: 2005-08-31
CHONGQING HUAPONT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, chloroform and other harmful solvents to the human body cannot be removed during concentration; after concentration, they are all viscous solids, which are difficult to take out from the container; the volume of the container for ultrasonic treatment is limited; the liposomes after treatment have a tendency to re-agglomerate, which affects drug release, etc.
[0008] Simultaneously, there is no retinoic acid complex liposome for preventing and treating epithelial cell abnormal skin diseases such as pigmentation dermatosis and skin photoaging on the market

Method used

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  • Composite liposome of vitaminaacid as well as preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 retinoic acid and licorice flavone composite liposome 1

[0029]Recipe: 1g of retinoic acid, 1.5g of glycyrrhizic acid, 4g of soybean lecithin (phosphorylcholine content 80%), 0.5g of Tween 60, 0.01g of di-tert-butyl-p-cresol, 40g of ethanol (85%), PBS solution (0.1 mol / L, pH7.2) 153g.

[0030] Preparation method: add retinoic acid, glycyrrhizic acid, soybean lecithin, Tween 60, and di-tert-butyl-p-cresol into ethanol, and stir until completely dissolved; pour the solution into PBS solution and mix evenly to obtain the complex liposome suspension solution.

Embodiment 2

[0031] Embodiment 2 retinoic acid and licorice flavone compound liposome 2

[0032] Recipe: Retinoic acid 1g, trisodium glycyrrhizinate 1.5g, soybean lecithin (phosphorylcholine content 80%) 4g, 0.5g Tween 60, di-tert-butyl-p-cresol 0.01g, ethanol (80%) 40g, PBS solution (0.1mol / L, pH7.2) 153g.

[0033] Preparation method: Add retinoic acid, trisodium glycyrrhizinate, soybean lecithin, Tween 60, and di-tert-butyl-p-cresol into ethanol, stir until fully dissolved; pour the solution into PBS solution and mix well to form liposomes suspension solution.

Embodiment 3

[0034] Embodiment 3 retinoic acid and licorice flavone compound liposome 3

[0035] Formula: Retinoic acid 1g, glycyrrhetinic acid 1.5g, soybean lecithin (phosphorylcholine content 85%)

[0036] 4g, 0.5g Tween-60, 0.01g di-tert-butyl-p-cresol, 40g ethanol (75%), 153g PBS solution (0.1mol / L, pH7.2).

[0037] Preparation method: add retinoic acid, glycyrrhetinic acid, lecithin, Tween 60, and di-tert-butyl-p-cresol into ethanol, and stir until completely dissolved; pour the solution into PBS solution and mix evenly until the mixture of liposomes suspension solution.

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Abstract

A composite lipid for treating and preventing pigmentation and photosenile dermatopathy is prepared from tretinoin, licoflavone, lecithin and surfactant through including the tretinoin and licoflavone in lecithin.

Description

【Technical field】 [0001] The invention relates to the field of pharmacy, and mainly relates to a composite liposome containing retinoic acid and licorice flavone, and a preparation method and application of the composite liposome. The composite liposome provided by the invention can reduce side effects during the use of retinoic acid, and can be used to prepare medicines or cosmetics for preventing and treating pigmentation skin diseases, photoaging and other epithelial abnormal skin diseases. 【Background technique】 [0002] Pigmented skin diseases are caused by excessive pigmentation on the skin due to damage to the pigment in the body, mainly including chloasma, freckles, sun spots, age spots, and post-inflammatory pigmentation and other skin diseases. Among them, chloasma is the most common, the main feature is the symmetrical hyperpigmentation, and it is easy to occur in the sun-exposed parts. There is no effective drug for the treatment of these diseases, and external ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/19A61K31/352A61P17/00
Inventor 陈瑞张壹李娟金百华
Owner CHONGQING HUAPONT PHARMA
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