Medical devices integrating cationic steroidal antimicrobial compounds

Abstract

This disclosure relates to medical devices incorporating one or more cationic steroidal antimicrobials (CSAs). The CSAs are incorporated into the medical devices to provide effective antimicrobial, anti-inflammatory, and / or tissue-healing properties. A medical device includes a component formed from a polymeric material. One or more CSA compounds are mixed with the polymeric material so that the one or more CSA compounds are incorporated into the structure of the medical device as formed from the polymeric material. A medical device can additionally or alternatively include a lubricious coating containing one or more CSA compounds.

Description

technical field [0001] The present disclosure relates generally to medical devices, including implantable medical devices in particular, which incorporate one or more cationic steroidal antimicrobial (CSA) compounds to provide antimicrobial activity, anti-inflammatory activity, pain relief, and increased rate of tissue healing one or more of. Background technique [0002] Medical devices include instruments that are used on the body of a subject for diagnostic or therapeutic purposes. In use, many medical devices are implanted in a subject, either as permanent implants or as temporary implants. However, even when strict sterilization procedures are followed, such medical implants can be subject to microbial contamination (e.g., biofilm formation). When biocontamination of an implant occurs, the implant must be removed from the subject. After contamination, medical devices are generally not suitable for further use and must be discarded. Often, contaminated implants must ...

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Problems solved by technology

While less severe cases of subglottic stenosis can be corrected with endoscopic laser surgery, more severe cases require reconstruction with cartilage grafts and stents

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