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Carbon quantum dot modified dual-network hydrogel and preparation method thereof

A carbon quantum dot and double network technology, applied in the field of carbon quantum dot modified double network hydrogel and its preparation, can solve problems such as human health and environmental hazards, achieve control of water loss, promote cell proliferation, and accelerate wound healing Effect

Active Publication Date: 2021-12-21
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Due to the multiple antibacterial modes, nanotechnology brings a strategy to alleviate the problem of antimicrobial hydrogel resistance. Metal and metal oxide nanoparticles have been introduced into hydrogels for wound treatment, but the use of metal or Metal oxide nanomaterials may cause harm to human health and the environment, so it is urgent to develop a material with good biocompatibility, high antibacterial activity and will not make bacteria resistant

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  • Carbon quantum dot modified dual-network hydrogel and preparation method thereof
  • Carbon quantum dot modified dual-network hydrogel and preparation method thereof
  • Carbon quantum dot modified dual-network hydrogel and preparation method thereof

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Embodiment 1

[0035] The preparation method of the carbon quantum dot modified double network hydrogel of the present embodiment comprises:

[0036] Step 1. Mix the oxidized dextran aqueous solution and the recombinant collagen aqueous solution to obtain the oxidized dextran-recombinant collagen mixed solution; the mass percentage of the oxidized dextran aqueous solution is 6%, and the oxidized glucan The number average molecular weight of the polysaccharide is 40000 Da, the mass percentage of the recombinant collagen in the recombinant collagen aqueous solution is 6%, and the volume ratio of the oxidized dextran aqueous solution and the recombinant collagen aqueous solution is 1:1;

[0037] Step 2: Dissolve kanamycin in the reaction kettle, treat at 160°C for 2 hours, then centrifuge at 15,000 rpm for 30 minutes, dialyze the centrifugate for 3 days with a dialysis bag with a cut-off of 1,000 Da, and filter it with a 0.22 μm filter membrane After lyophilization for 3 days, kanamycin carbon ...

Embodiment 2

[0042] The preparation method of the carbon quantum dot modified double network hydrogel of the present embodiment comprises:

[0043] Step 1. Mix the oxidized dextran aqueous solution and the recombinant collagen aqueous solution to obtain the oxidized dextran-recombined collagen mixed solution; the mass percentage of the oxidized dextran aqueous solution is 10%, and the oxidized glucan The number average molecular weight of the polysaccharide is 40000Da, the mass percentage of the recombinant collagen in the recombinant collagen aqueous solution is 8%, and the volume ratio of the oxidized dextran aqueous solution and the recombinant collagen aqueous solution is 1:1.5;

[0044] Step 2: Dissolve kanamycin in the reaction kettle, treat at 165°C for 2 hours, then centrifuge at 15,000 rpm for 30 minutes, dialyze the centrifugate for 3 days with a dialysis bag with a cut-off of 1,000 Da, and filter it with a 0.22 μm filter membrane Freeze-dry for 3 days to obtain kanamycin carbon ...

Embodiment 3

[0049] The double-network hydrogel modified by carbon quantum dots in this embodiment is prepared by introducing kanamycin carbon quantum dots into the double-network hydrogel system by chemical cross-linking; the double-network hydrogel modified by carbon quantum dots The pore size of the gel is 10 μm to 20 μm, and the size of the kanamycin carbon quantum dot is 1 nm to 5 nm.

[0050] The preparation method of the carbon quantum dot modified double network hydrogel of the present embodiment comprises:

[0051] Step 1. Mix the oxidized dextran aqueous solution and the recombinant collagen aqueous solution to obtain the oxidized dextran-recombined collagen mixed solution; the mass percentage of the oxidized dextran aqueous solution is 10%, and the oxidized glucan The number average molecular weight of the polysaccharide is 40000 Da, the mass percentage of the recombinant collagen in the recombinant collagen aqueous solution is 10%, and the volume ratio of the oxidized dextran a...

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Abstract

The invention discloses a carbon quantum dot modified dual-network hydrogel, which is prepared by introducing kanamycin carbon quantum dots into a dual-network hydrogel system in a chemical crosslinking manner; the aperture of the carbon quantum dot modified dual-network hydrogel is 10 [mu] m-20 [mu] m, and the size of the kanamycin carbon quantum dots is 1 nm-5 nm. In addition, the invention also provides a preparation method of the hydrogel. The first layer of network of the carbon quantum dot modified dual-network hydrogel is a Schiff base bond formed by the reaction of an aldehyde group and an amino group, the second layer of network is a hydrogen bond formed by polyvinyl alcohol through a circulating low-temperature freezing method, the Schiff base bond and the hydrogen bond are both reversible dynamic covalent bonds, bond breakage can be realized in a wound inflammation microenvironment, and the carbon quantum dots are released, so the purposes of sterilization and drug resistance are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a double network hydrogel modified by carbon quantum dots and a preparation method thereof. Background technique [0002] Hydrogel is a material with a three-dimensional network structure formed by cross-linking water-soluble polymers. Because of its cross-linked structure, hydrogel can absorb a large amount of water and swell without dissolving, so it has strong water absorption and water retention. It can absorb dozens to thousands of times of its own water without losing water. For wounds, most wounds exposed to tissue damage will be exposed, bacterial infection may occur during the repair process, and severe inflammatory responses usually slow down wound healing. Thousands of people die every year due to the problem of bacterial infection. To solve this problem, hydrogels containing antibiotics are a common choice for surgical infections, which have ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08L5/02C08L89/00C08K3/04A61L26/00
CPCC08J3/075A61L26/0033A61L26/0023A61L26/0014A61L26/0004A61L26/008A61L26/0066A61L26/0085C08J2329/04C08J2405/02C08J2489/00C08K3/04A61L2300/10A61L2300/404C08L89/00C08L5/02C08L29/04
Inventor 马晓轩孟霄范代娣杨静
Owner NORTHWEST UNIV
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