Carbon quantum dot modified dual-network hydrogel and preparation method thereof

A carbon quantum dot and double network technology, applied in the field of carbon quantum dot modified double network hydrogel and its preparation, can solve problems such as human health and environmental hazards, achieve control of water loss, promote cell proliferation, and accelerate wound healing Effect

Active Publication Date: 2021-12-21
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Due to the multiple antibacterial modes, nanotechnology brings a strategy to alleviate the problem of antimicrobial hydrogel resistance. Metal and metal oxide nanoparticles have been introduced into hydrogels for wound treatment

Method used

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  • Carbon quantum dot modified dual-network hydrogel and preparation method thereof
  • Carbon quantum dot modified dual-network hydrogel and preparation method thereof
  • Carbon quantum dot modified dual-network hydrogel and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0034] Example 1

[0035] The method of preparing a dual network hydrogel modified in this embodiment includes:

[0036] Step 1, mixed the oxidative dextran and recombinant collagen aqueous solution to obtain an oxidative dextran-recombinant collagen mixture; the oxidative glycan aqueous solution of oxidative glucosa is 6%, oxidation The number average molecular weight of glycans is 40000 Da, the mass percentage of recombinant collagen in recombinant collagen aqueous solution is 6%, and the volume ratio of oxidized glucan aqueous solution and recombinant collagen aqueous solution is 1: 1;

[0037] Step 2, kanamycin was dissolved in the reaction kettle and treated under 160 ° C for 2 h, then centrifuged at 15000 rpm for 30 min, and the centrifugation was used to dialyzate 3D using a dialysis bag of 1000 da, and then filtered with 0.22 μm. After three days, 3D is added to obtain kanamycin carbon quantum dots; kanamycin carbon quantum dots are added to the step of oxidative glucan-re...

Example Embodiment

[0041] Example 2

[0042] The method of preparing a dual network hydrogel modified in this embodiment includes:

[0043] Step, aqueous oxidative dextran aqueous solution and recombinant collagen aqueous solution are mixed to give oxidative dextran-recombinant collagen mixture; the oxidative glycan solution oxidative dextran is 10%, oxidation The number average molecular weight of glycans is 40000 Da, the mass content of recombinant collagen in recombinant collagen aqueous solution is 8%, and the volume ratio of oxidative dextran aqueous solution and recombinant collagen aqueous solution is 1: 1.5;

[0044] Step 2, the kanamycin was dissolved in the reaction kettle, treated at 165 ° C for 2 h, then centrifuged at 15000 rpm for 30 min, and the centrifugation was used to dialyzate 3D using a dialysis bag of 1000 DA, and then filtered with 0.22 μm filtration. Lyophilized 3D to obtain kanamycin carbon quantum dots; add kanamycin carbon quantum dots to the step of oxidative glucan-recom...

Example Embodiment

[0048] Example 3

[0049] The dual network hydrogel modified by the carbon quantum dot of the present embodiment uses a chemical crosslinking manner to introduce kanamycin carbon quantum dies into a dual network hydrogel system; the carbon quantum dot modified dual network water The gel pore size is 10 μm to 20 μm, and the size of the kanamycin carbon quantum dot is 1 nm to 5 nm.

[0050] The method of preparing a dual network hydrogel modified in this embodiment includes:

[0051] Step, aqueous oxidative dextran aqueous solution and recombinant collagen aqueous solution are mixed to give oxidative dextran-recombinant collagen mixture; the oxidative glycan solution oxidative dextran is 10%, oxidation The number average molecular weight of the glycan is 40000 Da, the mass percentage of recombinant collagen in the recombinant collagen aqueous solution is 10%, the volume ratio of the oxidative dextran aqueous solution and recombinant collagen aqueous solution is 1: 1;

[0052] Step 2...

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Abstract

The invention discloses a carbon quantum dot modified dual-network hydrogel, which is prepared by introducing kanamycin carbon quantum dots into a dual-network hydrogel system in a chemical crosslinking manner; the aperture of the carbon quantum dot modified dual-network hydrogel is 10 [mu] m-20 [mu] m, and the size of the kanamycin carbon quantum dots is 1 nm-5 nm. In addition, the invention also provides a preparation method of the hydrogel. The first layer of network of the carbon quantum dot modified dual-network hydrogel is a Schiff base bond formed by the reaction of an aldehyde group and an amino group, the second layer of network is a hydrogen bond formed by polyvinyl alcohol through a circulating low-temperature freezing method, the Schiff base bond and the hydrogen bond are both reversible dynamic covalent bonds, bond breakage can be realized in a wound inflammation microenvironment, and the carbon quantum dots are released, so the purposes of sterilization and drug resistance are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a double network hydrogel modified by carbon quantum dots and a preparation method thereof. Background technique [0002] Hydrogel is a material with a three-dimensional network structure formed by cross-linking water-soluble polymers. Because of its cross-linked structure, hydrogel can absorb a large amount of water and swell without dissolving, so it has strong water absorption and water retention. It can absorb dozens to thousands of times of its own water without losing water. For wounds, most wounds exposed to tissue damage will be exposed, bacterial infection may occur during the repair process, and severe inflammatory responses usually slow down wound healing. Thousands of people die every year due to the problem of bacterial infection. To solve this problem, hydrogels containing antibiotics are a common choice for surgical infections, which have ...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08L5/02C08L89/00C08K3/04A61L26/00
CPCC08J3/075A61L26/0033A61L26/0023A61L26/0014A61L26/0004A61L26/008A61L26/0066A61L26/0085C08J2329/04C08J2405/02C08J2489/00C08K3/04A61L2300/10A61L2300/404C08L89/00C08L5/02C08L29/04
Inventor 马晓轩孟霄范代娣杨静
Owner NORTHWEST UNIV
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