Silicon-based wound repair hydrogel and preparation method thereof

A wound repair, water-based technology, applied in medical science, bandages, etc., can solve problems such as uneven wound coverage, secondary wound damage, and inconvenient clinical use, and achieve the effect of accelerating wound healing, less irritation, and convenient clinical use

Inactive Publication Date: 2017-08-04
江西虹景天药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is inconvenient to use clinically, the wound is covered unevenly, and it is very irritating to the wound
It

Method used

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  • Silicon-based wound repair hydrogel and preparation method thereof
  • Silicon-based wound repair hydrogel and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: formula and preparation method

[0025] 1.1 Recipe

[0026] A silicon-based wound surface repairing aqueous gel, its raw material formula is as follows:

[0027]

[0028] Among them, carbomer is selected from carbomer 934, carbomer 940 and carbomer 941; the bioactive glass is 45S5 glass powder or 45S glass powder, and the particle size range is between 150nm and 800nm; propylene glycol is 1,2-propanediol; pearl powder is freshwater pearl powder or seawater pearl powder, ultrafine pearl powder with a particle diameter of less than 15 microns or nano pearl powder with a particle diameter of less than 100 nanometers.

[0029] 1.2 Preparation method

[0030] The preparation method of silicon-based wound repair aqueous gel of the present invention is:

[0031] a) Measure 40ml~60mL of glycerin and 45ml~70mL of 1,2-propanediol in a sterile container, fully miscible; weigh 0.8g~1.5g of carbomer, and sprinkle evenly on the surface of the solvent formed by mix...

Embodiment 2

[0034] Embodiment 2: experiment on promoting wound healing

[0035] 2.1 Materials

[0036] 20 SD rats, weighing 200-220 g, provided by Changsha Tianqin Biotechnology Co., Ltd.; silicon-based wound repair aqueous gel (self-made); sulfadiazine zinc ointment (Shanghai Jinyu Biotechnology Neixiang Pharmaceutical Co., Ltd.); optics Microscope (Shanghai Optical Instrument Factory).

[0037] 2.2 Method

[0038] SD rats were randomly divided into two groups: 16 rats in the sulfadiazine zinc ointment group, and 16 rats in the silicon-based wound repair aqueous gel group. The rat was anesthetized by intraperitoneal injection of 15% chloral hydrate (2ml / kg), and the rat was fixed on the operating table in the prone position after success. Remove the body hair on the back of the rat, rinse with water, disinfect with 75% alcohol, make a full-thickness skin defect wound with a diameter of 3 cm on the back, rinse with hydrogen peroxide, chlorhexidine, and normal saline locally, disinfect ...

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Abstract

The invention discloses a silicon-based wound repair hydrogel which is prepared from the following raw materials: 0.8-1.5g of carbomer, 40-60mL of glycerinum, 45-70mL of propylene glycol, 0.3-1.2g of gelatin, 6-16g of bioactive glass and 0.6-1.4g of pearl powder. A pearl powder component which contains calcium carbonate and various amino acids and is capable of providing local tissue of a wound with nutrients is added on the basis of a silicon-based wound repair mateiral, namely bioactive glass as a main repair material; meanwhile, the dosage form of the hydrogel is prepared under the condition of not adding water, so that the silicon-based wound repair material is prevented from degenerating in water, the dosage form has the characteristic that the hydrogel is painted for protecting the wound, and the silicon-based wound repair hydrogel is capable of keeping the wound moist, creating a low-oxygen and slight-acid environment, accelerating wound healing, absorbing seepage and cleaning the wound in an autolytic manner.

Description

technical field [0001] The invention belongs to the technical field of soft tissue repair, and in particular relates to a silicon-based aqueous gel for wound repair and a preparation method thereof. Background technique [0002] With the rapid development of modern medicine, especially molecular biology, new types of wound repair dressings are emerging. These repair dressings can not only cover the wound, but also have the function of promoting tissue repair, providing a growth environment for new tissue, accelerating wound healing, reducing the Prevents scarring, prevents bacterial contamination, and is biodegradable. [0003] The main components of silicon-based wound repair materials (also known as bioactive glass) are silicon dioxide, calcium oxide, phosphorus pentoxide, sodium oxide, etc., which have unique surface activity and can repair, replace and regenerate body tissues. Silicon-based wound repair materials are dissolved in body fluids to form negatively charged S...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0038A61L26/0066A61L26/008A61L2300/10A61L2300/214A61L2300/30A61L2300/412
Inventor 吴正平
Owner 江西虹景天药业有限公司
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